Advanced Drug Delivery Systems: Technologies and Global Markets (Market Research Report)

Chapter One: Introduction ........... 1
Study Objectives ........ 1
Reasons For Doing This Study ...... 1
Intended Audience ......... 2
Scope Of The Study ......... 2
Methodology .......... 2
Information Sources ......... 2
Bcc Online Services ............ 3
About The Author ........... 3
Related Bcc Research Reports ......... 4
Disclaimer ........... 4
Chapter Two: Executive Summary ........ 5
Executive Summary ........ 5
Summary Table Global Revenue Of Advanced Drug Delivery Systems By Region, Through 2016 ($ Millions) ..... 6
Summary Figure Global Revenue Of Advanced Drug Delivery Systems By Region, 2009-2016 ($ Millions) ...... 6
Chapter Three: Overview .......... 7
Definitions .......... 7
Need For The Dosage Forms ...... 8
Classification Of Drug Delivery According To Route Of Administration .......... 8
Oral Drug Delivery ....... 9
Significant Features Of Rapid Disintegrating Tablets .. 9
Table 1 Advantages And Disadvantages Of Oral Drug Delivery .......... 10
Injectable Or Parenteral Drug Delivery ... 10
Table 2 Advantages And Disadvantages Of Parenteral Drug Delivery ........ 11
Pulmonary Drug Delivery ...... 11
Table 3 Advantages And Disadvantages Of Pulmonary Drug Delivery ........ 12
Metered Dose Inhalers ......... 12
Table 4 Advantages And Disadvantages Of Metered Dose Inhalers .......... 13
Dry Powder Inhalers ....... 13
Topical Drug Delivery ......... 13
Transmucosal Drug Delivery ......... 14
Nasal Drug Delivery ....... 14
Table 5 Advantages And Disadvantages Of Nasal Drug Delivery .......... 15
Oral Mucosal Drug Delivery ..... 16
Table 6 Advantages And Disadvantages Of Oral Mucosal Drug Delivery ........ 16
Table 6 (Continued) ........ 17
Rectal Drug Delivery ...... 17
Table 7 Advantages And Disadvantages Of Rectal Drug Delivery .......... 18
Ocular Drug Delivery ...... 18
Table 8 Advantages And Disadvantages Of Ocular Drug Delivery .......... 19
Vaginal Drug Delivery ......... 19
Table 9 Advantages And Disadvantages Of Vaginal Drug Delivery .......... 20
Transdermal Drug Delivery ...... 20
Table 10 Advantages And Disadvantages Of Transdermal Drug Delivery ....... 21
Classification Of Drug Delivery Based On Technology ........... 22
Sustained Release Drug Delivery ..... 22
Table 11 Advantages And Disadvantages Of Sustained Release Drug Delivery ........ 23
Prodrugs ............ 23
Advantages Of Prodrugs ....... 23
Table 12 Advantages And Disadvantages Of Prodrugs ... 24
Implants And Iuds ........ 24
Table 13 Advantages And Disadvantages Of Implants And Iuds ........... 25
Targeted Drug Delivery .......... 25
Ideal Characteristics Of Targeted Drug Delivery ... 26
Nanoparticles ........ 26
Liposomes ......... 27
Table 14 Advantages And Disadvantages Of Liposomes .. 28
Monoclonal Antibodies ......... 28
Table 15 Advantages And Disadvantages Of Monoclonal Antibodies ........... 29
Polymeric Drug Delivery ........ 29
Table 16 Advantages And Disadvantages Of Polymers .... 30
Pegylation ........ 31
Table 17 Advantages And Disadvantages Of Pegylation ..... 31
Reasons And Evolution Of Drug Delivery Technologies ........ 32
Table 18 Evolution Of Drug Delivery Technologies .. 32
Classification By Application ........ 32
Table 19 Applications Of Sustained Release Dosage Forms ........... 33
Table 19 (Continued) ........... 34
Table 19 (Continued) ........... 35
Table 19 (Continued) ........... 36
Table 20 Applications Of Prodrugs ......... 36
Table 20 Continued) ............ 37
Table 21 Applications Of Transdermal Drug Delivery ... 37
Table 21 (Continued) ........... 38
Table 22 Applications Of Implants And Iuds ..... 39
Table 23 Applications For Pulmonary Drug Delivery ...... 39
Table 23 (Continued) ........... 40
Table 24 Applications Of Buccal Drug Delivery ....... 40
Table 25 Applications Of Rectal Drug Delivery ....... 41
Table 26 Applications Of Ocular Drug Delivery ....... 41
Table 26 (Continued) ........... 42
Table 27 Applications Of Vaginal Drug Delivery ..... 43
Table 28 Applications Of Liposomes ........ 43
Table 29 Applications Of Nanoparticles ........ 44
Table 30 Applications Of Nanoparticles ........ 44
Table 30 (Continued) ........... 45
Table 31 Applications Of Polymers ......... 45
Table 31 (Continued) ........... 46
Table 32 Applications Of Pegylation ..... 46
Chapter Four: Regulatory Aspects ....... 47
Table 33 New Approvals Of Various Advanced Drug
Delivery Systems, 2008 To June 2011 .... 47
Table 33 (Continued) ........... 48
Table 33 (Continued) ........... 49
Table 34 Safety Alerts, July 2007 To June 2011 ....... 50
Table 34 (Continued) ........... 51
Chapter Five: Industry Structure ......... 52
Manufacturers/ Suppliers Of Drug Delivery Systems ... 52
Sustained Release Dosage Forms ...... 52
Table 35 Leading Manufacturers/Suppliers Of
Sustained Release Oral Dosage Forms ...... 52
Table 35 (Continued) ........... 53
Table 36 Leading Manufacturers/Suppliers Of
Sustained Release Injectable Dosage Forms ....... 54
Table 37 Leading Manufacturers/Suppliers Of
Sustained Release Topical Dosage Forms ..... 55
Prodrugs ............ 55
Table 38 Leading Manufacturers/Suppliers Of
Prodrugs ............. 55
Table 38 (Continued) ........... 56
Table 39 Leading Manufacturers/Suppliers Of Implants
And Iuds ........... 56
Transdermal Drug Delivery Systems ........ 57
Table 40 Leading Manufacturers/Suppliers Of
Transdermal Drug Delivery Systems .... 57
Pulmonary Drug Delivery Systems ....... 58
Table 41 Leading Manufacturers/Suppliers Of
Pulmonary Drug Delivery Systems .... 58
Buccal Drug Delivery System ........ 59
Table 42 Leading Manufacturers/Suppliers Of Buccal
Delivery Systems ........... 59
Rectal Drug Delivery System .... 59
Table 43 Leading Manufacturers/Suppliers Of Rectal
Delivery Systems ........... 59
Ocular Drug Delivery System ........ 60
Table 44 Leading Manufacturers/Suppliers Of Ocular
Delivery Systems ........... 60
Table 44 (Continued) ........... 61
Vaginal Drug Delivery Systems .... 62
Table 45 Leading Manufacturers/Suppliers Of Vaginal
Delivery Systems ........... 62
Targeted Drug Delivery Systems ...... 62
Table 46 Leading Manufacturers/Suppliers Of
Liposomes ............ 62
Table 47 Leading Manufacturers/Suppliers Of
Nanoparticles ............ 63
Table 48 Leading Manufacturers / Suppliers Of
Monoclonal Antibodies ....... 63
Table 48 (Continued) ........... 64
Polymeric Drug Delivery ........ 64
Table 49 Leading Manufacturers/Suppliers Of
Polymers ............. 64
Table 49 (Continued) ........... 65
Table 50 Leading Manufacturers/Suppliers Of
Pegylated Products .......... 65
Market Shares Of Industry Leaders Of Drug Delivery
Systems .......... 66
Sustained Release Oral Dosage Forms ..... 66
Table 51 Global Market Shares Of
Manufacturers/Suppliers Of Sustained Release Oral
Dosage Forms, 2010 (%) ....... 66
Figure 1 Global Market Shares Of
Manufacturers/Suppliers Of Sustained Release Oral
Dosage Forms, 2010 (%) ........ 67
Sustained Release Injectable Dosage Forms ...... 67
Table 52 Global Market Shares Of
Manufacturers/Suppliers Of Sustained Release
Injectable Dosage Forms, 2010 (%) ....... 68
Figure 2 Global Market Shares Of
Manufacturers/Suppliers Of Sustained Release
Injectable Dosage Forms, 2010 (%) ........ 68
Sustained Release Topical Dosage Forms ... 69
Table 53 Global Market Shares Of Manufacturers/
Suppliers Of Sustained Release Injectable Dosage
Forms, 2010 (%) .......... 69
Figure 3 Global Market Shares Of
Manufacturers/Suppliers Of Sustained Release
Topical Dosage Forms, 2010 (%) .......... 70
Prodrugs ............ 70
Table 54 Global Market Shares Of Manufacturers/
Suppliers Of Prodrugs, 2010 (%) ...... 71
Figure 4 Global Market Shares Of
Manufacturers/Suppliers Of Prodrugs, 2010 (%) ..... 71
Implants And Iuds ........ 72
Table 55 Global Market Shares Of
Manufacturers/Suppliers Of Implants And Iuds, 2010
(%) .............. 72
Figure 5 Global Market Shares Of
Manufacturers/Suppliers Of Implants And Iuds, 2010
(%) .............. 73
Pulmonary Drug Delivery Systems ....... 73
Table 56 Global Market Shares Of
Manufacturers/Suppliers Of Pulmonary Drug
Delivery Systems, 2010 (%) .......... 74
Figure 6 Global Market Shares Of
Manufacturers/Suppliers Of Pulmonary Drug
Delivery Systems, 2010 (%) .......... 74
Transdermal Drug Delivery Systems ........ 75
Table 57 Global Market Shares Of
Manufacturers/Suppliers Of Transdermal Drug
Delivery Systems, 2010 (%) ......... 75
Figure 7 Global Market Shares Of
Manufacturers/Suppliers Of Transdermal Drug
Delivery Systems, 2010 (%) .......... 76
Buccal Drug Delivery Systems ...... 76
Table 58 Global Market Shares Of
Manufacturers/Suppliers Of Buccal Drug Delivery
Systems, 2010 (%) ......... 76
Figure 8 Global Market Shares Of
Manufacturers/Suppliers Of Buccal Drug Delivery
Systems, 2010 (%) .......... 77
Rectal Drug Delivery Systems ....... 77
Table 59 Global Market Shares Of
Manufacturers/Suppliers Of Rectal Drug Delivery
Systems, 2010 (%) ......... 77
Figure 9 Global Market Shares Of
Manufacturers/Suppliers Of Rectal Drug Delivery
Systems, 2010 (%) .......... 78
Ocular Drug Delivery Systems ...... 78
Table 60 Global Market Shares Of
Manufacturers/Suppliers Of Ocular Drug Delivery
System, 2010 (%) ............ 79
Figure 10 Global Market Shares Of
Manufacturers/Suppliers Of Ocular Drug Delivery
Systems, 2010 (%) .......... 79
Vaginal Drug Delivery Systems .... 80
Table 61 Global Market Shares Of Manufacturers/
Suppliers Of Vaginal Drug Delivery System, 2010 (%) ... 80
Figure 11 Global Market Shares Of
Manufacturers/Suppliers Of Vaginal Drug Delivery
Systems, 2010 (%) .......... 81
Liposomes .......... 81
Table 62 Global Market Shares Of Manufacturers/
Suppliers Of Liposomes, 2010 (%) .......... 82
Figure 12 Global Market Shares Of
Manufacturers/Suppliers Of Liposomes, 2010 (%) .... 82
Nanoparticles .......... 83
Table 63 Global Market Shares Of Manufacturers/
Suppliers Of Nanoparticles, 2010 (%) ..... 83
Figure 13 Global Market Shares Of
Manufacturers/Suppliers Of Nanoparticles, 2010 (%) .... 84
Monoclonal Antibodies .......... 84
Table 64 Global Market Shares Of
Manufacturers/Suppliers Of Monoclonal
Antibodies, 2010 (%) ......... 85
Figure 14 Global Market Shares Of
Manufacturers/Suppliers Of Monoclonal
Antibodies, 2010 (%) ......... 85
Polymers ............ 86
Table 65 Global Market Shares Of Manufacturers/
Suppliers Of Polymers, 2010 (%) ....... 86
Figure 15 Global Market Shares Of
Manufacturers/Suppliers Of Polymers, 2010 (%) ...... 87
Pegnology ......... 87
Table 66 Global Market Shares Of
Manufacturers/Suppliers Of Pegnology, 2010 (%) .. 88
Figure 16 Global Market Shares Of
Manufacturers/Suppliers Of Pegnology, 2010 (%) ... 88
Chapter Six: New Developments ......... 89
Table 67 New Developments In Sustained Release Oral
Dosage Forms ......... 89
Table 68 New Developments In Sustained Release
Injectable Dosage Forms ......... 90
Table 69 New Developments In Topical Oral Dosage
Forms ........... 90
Table 70 New Developments In Implants And Iuds ... 91
Table 71 New Developments In Transdermal Drug
Delivery Systems ........... 92
Table 72 New Developments In Liposomal Drug Delivery ... 92
Table 73 New Developments In Pegylated Drug Delivery .. 93
Table 74 New Developments In Nanoparticle Drug
Delivery .......... 93
Table 74 (Continued) ........... 94
Table 75 New Developments In Buccal Drug Delivery ..... 94
Table 76 New Developments In Vaginal Drug Delivery ... 94
Table 77 New Developments In Rectal Drug Delivery ..... 95
Table 78 New Developments In Inhalation Drug Delivery ...... 95
Table 78 (Continued) ........... 96
Table 78 (Continued) ........... 97
Table 79 New Developments In Prodrugs ...... 97
Table 79 (Continued) ........... 98
Table 80 New Developments In Monoclonal Antibodies ..... 98
Table 80 (Continued) ........... 99
Table 80 (Continued) ......... 100
Table 80 (Continued) ......... 101
Table 80 (Continued) ......... 102
Table 80 (Continued) ......... 103
Table 80 (Continued) ......... 104
Table 80 (Continued) ......... 105
Chapter Seven: Market Analysis ...... 106
Market Analysis .......... 106
Market Revenue .......... 107
Table 81 Global Market For Advanced Drug Delivery
System, Through 2016 ($ Millions) ..... 107
Figure 17 Global Market For Advanced Drug Delivery
System, 2009-2016 ($ Millions) ....... 108
Sustained Release Dosage Forms .... 108
Oral Delivery Systems ........ 108
Market Overview .......... 109
Market Revenue ....... 110
Table 82 Global Market For Sustained Release Oral
Dosage Forms By Region, Through 2016 ($ Millions) .... 110
Figure 18 Global Market For Sustained Release Oral
Dosage Forms By Region, 2009-2016 ($ Millions) ..... 111
Injectables ......... 111
Market Overview ...... 112
Market Overview (Continued) ..... 113
Market Revenue ....... 114
Table 83 Global Market For Sustained Release
Injectable Dosage Forms By Region, Through 2016 ($
Millions) ............ 114
Figure 19 Global Market For Sustained Release
Injectable Dosage Forms By Region, 2009-2016 ($
Millions) ............ 115
Topical ......... 115
Market Overview ...... 116
Market Revenue ....... 117
Table 84 Global Market For Sustained Release Topical
Dosage Forms By Region, Through 2016 ($ Millions) .... 117
Figure 20 Global Market For Sustained Release Topical
Dosage Forms By Region, Through 2016 ($ Millions) .... 118
Prodrugs .......... 118
Market Overview ...... 119
Market Revenue ....... 120
Table 85 Global Market For Prodrugs By Region,
Through 2016 ($ Millions) ......... 120
Figure 21 Global Market For Prodrugs By Region, 2009-
2016 ($ Millions) ......... 120
Transdermal Drug Delivery .... 121
Market Overview ...... 122
Market Revenue ....... 123
Table 86 Global Market For Transdermal Drug Delivery
Systems By Region, Through 2016 ($ Millions) ...... 124
Figure 22 Global Market For Transdermal Drug
Delivery Systems By Region, 2009-2016 ($ Millions) .. 124
Implants And Iuds ...... 124
Market Overview ...... 125
Market Overview (Continued) ..... 126
Market Revenue ....... 127
Table 87 Global Market For Implants And Iuds By
Region, Through 2016 ($ Millions) ..... 127
Figure 23 Global Market For Implants And Iuds By
Region, 2009-2016 ($ Millions) ....... 128
Pulmonary Drug Delivery/Inhalation ... 128
Market Overview ...... 128
Market Revenue ....... 129
Table 88 Global Market For Pulmonary Drug Delivery
Systems By Region, Through 2016 ($ Millions) ..... 130
Figure 24 Global Market For Pulmonary Drug Delivery
Systems By Region, 2009-2016 ($ Millions) ....... 130
Buccal Drug Delivery ........ 131
Market Overview ...... 131
Market Revenue ....... 132
Table 89 Global Market For Buccal Drug Delivery
Systems By Region, Through 2016 ($ Millions) ..... 132
Figure 25 Global Market For Buccal Drug Delivery
Systems By Region, 2009-2016 ($ Millions) ....... 133
Rectal Drug Delivery ........ 133
Market Overview ...... 133
Market Revenue ....... 134
Table 90 Global Market For Rectal Drug Delivery
Systems By Region, Through 2016 ($ Millions) ..... 134
Figure 26 Global Market For Rectal Drug Delivery
Systems By Region, 2009-2016 ($ Millions) ....... 135
Ocular Drug Delivery ....... 135
Market Overview ...... 136
Market Revenue ....... 137
Table 91 Global Market For Ocular Drug Delivery
Systems By Region, Through 2016 ($ Millions) ..... 137
Figure 27 Global Market For Ocular Drug Delivery
Systems By Region, 2009-2016 ($ Millions) ....... 138
Vaginal Drug Delivery ...... 138
Market Overview ...... 139
Market Revenue ....... 139
Table 92 Global Market For Vaginal Drug Delivery
Systems By Region, Through 2016 ($ Millions) ..... 139
Figure 28 Global Market For Vaginal Drug Delivery
Systems By Region, 2009-2016 ($ Millions) ....... 140
Targeted Drug Delivery ........ 140
Nanoparticles ....... 140
Market Overview .......... 141
Market Revenue ....... 142
Table 93 Global Market For Nanoparticles By Region,
Through 2016 ($ Millions) ......... 142
Figure 29 Global Market For Nanoparticles By Region,
2009-2016 ($ Millions) .......... 143
Liposomes ........ 143
Market Overview .......... 144
Market Revenue ....... 145
Table 94 Global Market For Liposomes By Region,
Through 2016 ($ Millions) ......... 146
Figure 30 Global Market For Liposomes By Region, 2009-
2016 ($ Millions) ......... 146
Monoclonal Antibodies ....... 146
Market Overview .......... 147
Market Overview (Continued) ....... 148
Market Revenue ....... 149
Table 95 Global Market For Monoclonal Antibodies By
Region, Through 2016 ($ Millions) ..... 149
Figure 31 Global Market For Monoclonal Antibodies By
Region, 2009-2016 ($ Millions) ........ 150
Polymeric Drug Delivery ...... 150
Market Overview ...... 150
Market Overview (Continued) ..... 151
Market Revenue ....... 152
Table 96 Global Market For Polymers By Region,
Through 2016 ($ Millions) ......... 152
Figure 32 Global Market For Polymers By Region, 2009-
2016 ($ Millions) ......... 153
Pegylated Products ...... 153
Market Overview ...... 153
Market Overview (Continued) ..... 154
Market Revenue ....... 155
Table 97 Global Market For Pegylated Products By
Region, Through 2016 ($ Millions) ...... 155
Figure 33 Global Market For Pegylated Products By
Region, 2009-2016 ($ Millions) ........ 156
Market Shares Of Drug Delivery Dosage Forms,
By Region ......... 156
Table 98 Global Drug Delivery Market Shares By Region,
2010 (%) ............. 156
Figure 34 Global Drug Delivery Market Shares By
Region, 2010 (%) ........... 157
Chapter Eight: Market By End Users ........ 158
Table 99 Global Market For Drug Delivery Dosage
Forms By Application, Through 2016 ($ Millions) ... 158
Figure 35 Global Market For Drug Delivery Dosage
Forms By Application, 2009-2016 ($ Millions) ..... 159
Cardiovascular Diseases ...... 160
Market Revenue .......... 160
Table 100 Global Revenue For Cardiovascular Drug
Delivery Systems, Through 2016 ($ Millions) ....... 161
Figure 36 Global Revenue For Cardiovascular Drug
Delivery Systems, 2009-2016 ($ Millions) ..... 161
Global Market Shares ........ 162
Table 101 Global Market Shares Of Cardiovascular
Drug Delivery Systems By Region, 2010 (%) .... 162
Figure 37 Global Market Shares Of Cardiovascular
Drug Delivery Systems By Region, 2010 (%) .... 162
Oncology .......... 163
Market Revenue .......... 163
Table 102 Global Revenue For Oncology Drug Delivery
Systems, Through 2016 ($ Millions) ....... 164
Figure 38 Global Revenue For Oncology Drug Delivery
Systems, 2009-2016 ($ Millions) ......... 164
Global Market Shares ........ 165
Table 103 Global Market Shares Of Oncology Drug
Delivery Systems By Region, 2010 (%) ..... 165
Figure 39 Global Market Shares Of Oncology Drug
Delivery Systems By Region, 2010 (%) ...... 165
Gastrointestinal Systems ......... 166
Market Revenue .......... 166
Table 104 Global Revenues For Gastrointestinal Drug
Delivery Systems, Through 2016 ($ Millions) ....... 167
Figure 40 Global Revenues For Gastrointestinal Drug
Delivery Systems, 2009-2016 ($ Millions) ..... 167
Global Market Shares ........ 168
Table 105 Global Market Shares Of Gastrointestinal
Drug Delivery Systems By Region, 2010 (%) ........ 168
Figure 41 Global Market Shares Of Gastrointestinal
Drug Delivery Systems By Region, 2010 (%) .... 168
Urology ............. 169
Market Revenue .......... 169
Table 106 Global Revenue Of Urology Drug Delivery
Systems, Through 2016 ($ Millions) ........ 170
Figure 42 Global Revenue Of Urology Drug Delivery
Systems, 2009-2016 ($ Millions) ......... 170
Global Market Share .......... 171
Table 107 Global Market Shares Of Urology Drug
Delivery Systems By Region, 2010 (%) ..... 171
Figure 43 Global Market Shares Of Urology Drug
Delivery Systems By Region, 2010 (%) ...... 171
Diabetes ............ 172
Market Revenue .......... 172
Table 108 Global Revenue For Drug Delivery Systems In
Diabetes, Through 2016 ($ Millions) ....... 173
Figure 44 Global Revenue For Drug Delivery Systems In
Diabetes, 2009-2016 ($ Millions) ........ 173
Global Market Shares ........ 173
Table 109 Global Market Shares Of Drug Delivery
Systems In Diabetes By Region, 2010 (%) .... 174
Figure 45 Global Market Shares Of Drug Delivery
Systems In Diabetes By Region, 2010 (%) ..... 174
Central Nervous System ....... 174
Market Revenue .......... 175
Table 110 Global Revenues For Central Nervous System
Drug Delivery Systems, Through 2016 ($ Millions) ..... 175
Figure 46 Global Revenues For Central Nervous System
Drug Delivery Systems, 2009-2016 ($ Millions) ....... 176
Global Market Shares ........ 176
Table 111 Global Market Shares Of Central Nervous
System Drug Delivery Systems By Region, 2010 (%) .. 176
Figure 47 Global Market Shares Of Central Nervous
System Drug Delivery Systems By Region, 2010 (%) .. 177
Respiratory Drug Delivery Systems .... 177
Market Revenue .......... 177
Table 112 Global Revenue For Respiratory Drug
Delivery Systems, Through 2016 ($ Millions) ... 178
Figure 48 Global Revenue For Respiratory Drug
Delivery Systems, 2009-2016 ($ Millions) .... 178
Global Market Shares ........ 179
Table 113 Global Market Shares Of Respiratory Drug
Delivery Systems By Region, 2010 (%) ..... 179
Figure 49 Global Market Shares Of Respiratory Drug
Delivery Systems By Region, 2010 (%) ...... 179
Inflammatory Diseases And Allergies .... 180
Market Revenue .......... 180
Table 114 Global Revenues For Drug Delivery Systems
For Inflammatory Diseases And Allergies, Through
2016 ($ Millions) ......... 180
Figure 50 Global Revenues For Drug Delivery Systems
For Inflammatory Diseases And Allergies, 2009-2016 ($
Millions) ............ 181
Global Market Shares ........ 181
Table 115 Global Market Shares Of Drug Delivery
Systems For Inflammatory Diseases And Allergies By
Region, 2010 (%) .......... 181
Figure 51 Global Market Shares Of Drug Delivery
Systems For Inflammatory Diseases And Allergies By
Region, 2010 (%) ........... 182
Ophthalmology ........... 182
Market Revenue .......... 182
Table 116 Global Revenue For Drug Delivery Systems In
Ophthalmology, Through 2016 ($ Millions) ...... 183
Figure 52 Global Revenue For Drug Delivery Systems In
Ophthalmology, 2009-2016 ($ Millions) ........ 183
Global Market Shares ........ 184
Table 117 Global Market Share Of Drug Delivery
Systems In Ophthalmology By Region, 2010 (%) .... 184
Figure 53 Global Market Share Of Drug Delivery
Systems In Ophthalmology By Region, 2010 (%) ..... 184
Viral And Bacterial Diseases ........ 185
Market Revenue .......... 185
Table 118 Global Revenue For Drug Delivery Systems
For Viral And Bacterial Diseases, Through 2016 ($
Millions) ............ 185
Figure 54 Global Revenue For Drug Delivery Systems
For Viral And Bacterial Diseases, 2009-2016 ($ Millions) ...... 186
Global Market Shares ........ 186
Table 119 Global Market Shares Of Drug Delivery
Systems For Viral And Bacterial Diseases By Region,
2010 (%) ............. 186
Figure 55 Global Market Shares Of Drug Delivery
Systems For Viral And Bacterial Diseases By Region,
2010 (%) ............. 187
Hormone Replacement Therapy (Hrt) And Gynecology .... 187
Market Revenue .......... 187
Table 120 Global Revenue For Drug Delivery Systems
For Hormone Replacement Therapy And Gynecology,
Through 2016 ($ Millions) ........ 188
Figure 56 Global Revenue For Drug Delivery Systems
For Hormone Replacement Therapy And Gynecology,
2009-2016 ($ Millions) .......... 188
Global Market Shares ........ 189
Table 121 Global Market Shares Of Drug Delivery
Systems For Hormone Replacement Therapy And
Gynecology By Region, 2010 (%) ....... 189
Figure 57 Global Market Shares Of Drug Delivery
Systems Hormone Replacement Therapy And
Gynecology, 2010 (%) .......... 189
Others ........... 190
Market Revenue .......... 190
Table 122 Global Revenue For Drug Delivery Systems
For Other Diseases, Through 2016 ($ Millions) ... 190
Figure 58 Global Revenue For Drug Delivery Systems
For Other Diseases, 2009-2016 ($ Millions) ...... 191
Global Market Shares ........ 191
Table 123 Global Market Shares Of Drug Delivery
Systems For Other Diseases By Region, 2010 (%) ... 191
Figure 59 Global Market Share Of Drug Delivery
Systems For Other Diseases By Region, 2010 (%) ... 192
Technologies ........... 192
Market Revenue .......... 192
Table 124 Global Revenue For Drug Delivery
Technologies, Through 2016 ($ Millions) .... 193
Figure 60 Global Revenue For Drug Delivery
Technologies, 2009-2016 ($ Millions) ...... 193
Global Market Shares ........ 193
Table 125 Global Market Shares Of Drug Delivery
Technologies By Region, 2010 (%) ...... 194
Figure 61 Global Market Shares Of Drug Delivery
Technologies By Region, 2010 (%) ...... 194
Market Share Of Applications ...... 195
Table 126 Shares Of Drug Delivery Systems By
Applications, 2010 (%) ........ 195
Figure 62 Share Of Drug Delivery Systems By
Applications, 2010 (%) ....... 195
Chapter Nine: Patent Analysis .......... 196
Patents By Year ............ 196
Table 127 Significant Patents By Year, 2007-2011
(Number/%) ........ 197
Figure 63 Number Of Patents By Year, 2007-2011 ....... 197
Figure 64 Significant Of Patents By Year, 2007-2011 (%) .. 198
Patents By Type ............ 198
Table 128 Patents By Type, 2007-2011 ....... 199
Figure 65 Total Patents By Type, 2007-2011 (%) ....... 199
Figure 65 (Continued) ........... 200
Patents By Company ........ 200
Table 129 Number Of U.S. Patents By Company For Drug
Delivery Systems, 2007-2011 ......... 201
Table 129 (Continued) ............ 202
Table 129 (Continued) ............ 203
Patents By Country ........ 203
Table 130 Total Number Of U.S. Patents By Country, 2007-
2011 .............. 204
Patents By Assignee ....... 204
Table 131 Patents By Assignee For Drug Delivery
Systems, 2007-2011 .......... 205
Figure 66 Patents By Assignee For Drug Delivery
Systems, 2007-2011 .......... 205
Chapter Ten: Current Situation, Strategies, And
Prospects .......... 206
Market Status ......... 206
Factors Affecting The Drug Delivery Market .. 206
Patent Expiration ...... 206
Table 132 Brands Coming Off-Patent, 2011-2012 .... 207
Hurdles In Launching New Chemical Entities .. 207
Increasing Demand Of Protein Therapeutics .... 208
Development Of Targeted Drug Delivery
Carriers ........... 208
Rising Need For Targeted Drug Delivery ... 208
Baby Boomer Generation ...... 208
Poor Efficacy Of Certain Drugs ....... 209
Competition ......... 209
Increased R&D And Government Funding .. 209
Company Strategies ....... 210
Settlements Between Brand And Generic Drug
Manufacturers ...... 210
Merger & Acquisitions And In-Licensing/
Partnership ........ 210
Table 133 Products Of Nektar Via Partnerships .... 211
Table 134 Products Of Elan Drug Technologies In
Partnership .......... 211
Demands And Trends ........... 211
Demands And Trends (Continued) .... 212
Chapter Eleven: Company Profiles ...... 213
Abbott Laboratories ........... 213
Akela Pharma Inc. ............ 213
Akorn Inc. ......... 214
Alcon Inc. ......... 214
Alexion Pharmaceuticals .......... 215
Alkermes, Inc. .......... 215
Allergan ........... 216
Alpharx ............. 216
Amgen ............ 217
A.P. Pharma ............ 218
Astellas Pharma Inc. ........... 218
Astrazeneca Plc .......... 219
Aton Pharma ........ 219
Baxter ........... 220
Bayer Healthcare Pharmaceuticals ....... 221
Biogen Idec ........... 221
Biosante Pharmaceuticals Inc. ......... 222
Boehringer Ingelheim ....... 222
Bristol Myers Squibb .......... 223
Celgene Corporation 86 Morris Avenue ...... 223
Cephalon Inc. ........... 224
Columbia Laboratories Inc. ...... 225
Eisai Co. .............. 225
Elan Drug Technologies ....... 226
Enzon Pharmaceuticals ......... 226
Eurand N.V. ............ 227
Genentech ............ 227
Generex Biotechnology Corporation ..... 228
Genzyme ............ 228
Gilead Sciences, Inc. ....... 229
Glaxosmithkline Plc .......... 230
Imclone Systems .......... 230
Janssen Biotech Inc. ....... 231
Johnson & Johnson ......... 231
Kv Pharmaceutical Co. ...... 232
Lavipharm Corporation .......... 233
3m Company ........... 233
Merck & Co. ........... 234
Mylan Laboratories Inc. ........ 235
Nektar Therapeutics .......... 235
Neurogesx Inc. ......... 236
Noven Pharmaceuticals, Inc. ......... 237
Novartis Ag .......... 237
Novavax, Inc. ........ 238
Nycomed Us Inc. ............ 239
Osi Pharmaceuticals Inc. ....... 239
Par Pharmaceutical Companies, Inc. ........ 240
Pdl Biopharma Inc. ........... 240
Pfizer Inc. ......... 241
Qlt Inc. .......... 241
Roche Holding Ag ............ 242
Sanofi Sa ........... 243
Teva Pharmaceutical Industries Ltd. ..... 243
Valeant Pharmaceuticals International ...... 244
Watson Pharmaceuticals, Inc. ...... 245
Appendix I-Abbreviations/Definitions .... 246
Abbreviations/Definitions ......... 246
Abbreviations/Definitions (Continued) ...... 247