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Biomarkers in Alzheimer's Disease 2011

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Market

Healthcare and Medical

Report Type

Market Research

Country

Global

Published

15 April 2011

Number of Pages

175

Report Delivery

Email

Delivery Lead Time

1-3 hours, 24 hour max

Publisher

Biopharm Reports

File Format

-

This report provides an overview of biomarkers associated with Alzheimer's disease (AD) that have potential in differential diagnosis, in following treatment, in clinical trials and drug discovery. These include molecules found in CSF and blood, genotypes, image-based parameters and others.

AD biomarkers offer utility in a number of ways: identification of groups at risk of developing AD; early detection of AD; differentiation of different forms of neurodegenerative disease from AD, as well as developmental stages (such as MCI), thought to progress to AD; supporting specific treatments or pharmacological interventions; following the time-course progression of AD and response to therapy; assessing patient prognosis; advancing understanding of the disease, including risk factors, and the changes that precede its development; the identification of new drug targets and candidate molecules; development of discovery assays for efficacy or toxicity markers; and supporting the recruitment of subjects most likely to provide a meaningful analysis of treatment effects. These areas are, therefore, considered and discussed in relation to the AD biomarkers presented in this report.

Of the biomarker areas being researched, the goal of developing methods for the early detection of AD, including the prediction of risk in particular patient groups, is a key priority. It is believed that the first symptoms of AD – generally diagnosed using cognitive, behavioural and functional assessments – occur after significant neuronal loss has already occurred. Consequently, it is thought that patients diagnosed at this stage will be less likely to gain benefits from treatment. This also hampers the development of disease-altering therapies, because, without adequate comparators (e.g. showing those who have the disease, or a particular developmental stage such as MCI, compared to healthy controls), it is difficult or impossible to evaluate treatment effects. Therefore, in the preparation of this report, emphasis was given to identifying biomarkers with potential in the early detection of the disease, or alternatively, in differentiating different stages or types of neurodegenerative disease, thought to be related to AD.

This Report

There are many AD biomarker studies; a report of this nature can provide only a general overview. More than 750 studies have been reviewed in its preparation (up to January 2011), and the findings from a short-list of approximately 150 studies are presented and discussed. The key goals of this report are practical in nature – to identify biomarkers that show the greatest potential in advancing research and development in the diagnosis and treatment of AD. The goals are as follows:
a) to review studies published over the last decade (up to Jan 2011) for short-listing;
b) to identify controlled clinical studies relating to AD and/or neurodegenerative conditions or stages believed to precede AD (e.g. MCI), that included the study of biomarkers (blood, CSF, genetic, image-based and others); and
c) to short-list opportunities to develop tests in the areas of utility indicated, with a particular emphasis on the early detection of AD or following disease progression.

Significant advances in this field have occurred in recent years. While considerable effort has focused on Abeta and tau related markers, a substantial number of other molecules and parameters have been identified, that may offer opportunities. Increasingly, correlations are also being seen between different types such as imaging and species found in CSF. This report identifies 99 candidate AD biomarkers and their associated studies. These were identified in CSF (40) and blood (18), using imaging (25) or genotypes (11), and others (5). Approximately 30 percent were linked with the early detection of AD.

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Select License Type

Electronic License

Electronic License

An electronic version (mostly PDF, but can be Excel or PPT), which is either available for immediate download or will be sent via email by the Publisher of the report. The licencing for an electronic version is for use by the purchaser ONLY.

Site License

Site License

An electronic version (mostly PDF, but can be Excel or PPT). Where the report(s) is intended for use by more than one individual, across for example, a site, an office, or a division or country.

Corporate License

Corporate License

An electronic version (mostly PDF, but can be Excel or PPT). Where the report(s) is/are intended for use by an organisation in its entirety. For example, if reports are put on an Intranet or if they are distributed or used by more than one office, division, or country operation, then a Corporate Licence is required.

Hard Copy License

Hard Copy License

As described. Hard copy reports are dispatched in the post/mail. However, the majority of our reports are in PDF and are either available for immediate download or they are sent by email within hours of purchase.

Disk License

Disk License

As described. The CD-Rom (where available) is dispatched in the post/mail. However, the majority of our reports are in PDF and are either available for immediate download or they are sent by email within hours of purchase.

£1,490.00

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