Cardiac Biomarkers - A Global Market Perspective

1.METHODOLOGY
Study Reliability and Reporting Limitations
Disclaimers
Quantitative Techniques & Reporting Level
2.INDUSTRY OVERVIEW
Cardiovascular Diseases: Leading Cause of Mortality Worldwide
Basic Topologies of Cardiovascular Diseases
Fast and Accurate Diagnosis – Reduce Unnecessary Healthcare Costs
Cardiac Biomarkers - Making Diagnosis Easier and Quicker
What is a Cardiac Marker:
Necessity of a Cardiac Marker Assay Test
Major Cardiac Markers and their Properties
Market Outlook
Market Trends
Strong Demand for Risk Assessment Markers
Intense Competition among Players in the Cardiac Diagnostics Market
The Future of Cardiac Marker POCT Segment
Need for Early Detection Markers
Rapid Turnaround time: A Crucial Parameter for POC Testing Kits
3.COMPETITIVE ANALYSIS
Siemens Healthcare becomes the leader, after a series of Acquisitions
Product Portfolio of Bayer and Dade Behring
4.CARDIAC MARKERS AND MYOCARDIAL INFARCTION
Chain Reaction After an Event of MI
Action Plan after an Event of MI
Protocol for Conducting AMI Markers Tests
Creatine Kinase – The Traditional Gold Standard, Loosing Sheen
Isomers
Kinetics
Purpose of Test and When to Order
Cardiac Troponin – Taking Over from CK-MB
Overview
Troponin Tissue-Specific Subtypes
Other Diseases
Uses of Troponin Tests
New Advanced High-sensitivity (Hs) Cardiac Troponin Tests
Myoglobin
Purpose of Test and When to Order
5.CARDIAC MARKERS AND CONGESTIVE HEART FAILURE (CHF)
Key Facts
BNP (B-type Natriuretic Peptide)
NT-proBNP (N-terminal proBNP)
Purpose of Tests and When to Order
Market Characteristics
Choosing the Right BNP and NT proBNP Assay Kit in the Market
Evolution of BNP and NT proBNP Market
NT-proBNP is superior to BNP in Predicting Mortality in Heart Failure Patients, with Reduced Kidney Function
6.STROKE BIOMARKERS - A REVIEW
Player Initiatives
Other Important Cardiac Biomarkers
Homocysteine
C-Reactive Protein
Plasminogen Activator Inhibitor-1
D-Dimer
Thrombus Precursor Protein
Potential Future Cardiac Biomarkers
7.CARDIAC BIOMARKER TESTING IN CLINICAL LABORATORIES
Leading Players in Laboratory Cardiac Markers
8.CARDIAC BIOMARKERS AT POINT-OF- CARE TESTING
Major Players Operating in the Cardiac Markers POCT Segment
Cardiac Markers Point-of-Care testing (POCT) Segment: Major Players & Their Operating Brands
9.CORPORATE DEVELOPMENTS
Response Biomedical Signs Partnership Agreement with Roche
Nanogen and Elitech Plans to Merge
Compugen Announces Discovery of Troponin I Biomarker Variant, Inks Agreement with Biosite
Response Bags FDA Clearance for RAMP® NT-proBNP Test
Inverness Acquires Biosite
Siemens Acquires Diagnostic Division of Bayer Healthcare
Siemens Announces Acquisition of Dade Behring
Beckman Collaborates in CVD Related Research Projects
Dade Behring Receives Sublicense to New Cardiac Marker
Inverness Acquires Cholestech
Response Biomedical Secures Clearance to Market RAMP® NT- proBNP Test
Acrongenomics Collaborates with Molecular Vision and Pearson Matthews
BG Medicine Obtains Rights to Develop Tests for Congestive Heart Failure
Nanogen Gains US Reissue Patent for Combined Use of Biomarkers for CHF Diagnosis
bioMérieux Rolls out VIDAS® NT-proBNP
Roche Diagnostics Introduces Cobas-H-232Handheld Cardiac Marker System
XIS Discovers a Unique Diagnostic Biomarker for Cardiovascular Disease
Ortho-Clinical Presents Sensitivity Troponin I Test, VITROS Troponin I ES
10.MAJOR PLAYERS
Abbott Diagnostics (USA)
Ani Biotech Oy (Finland)
Axis-Shield PoC (UK)
Beckman Coulter, Inc. (USA)
biomérieux (France)
Inverness Medical Innovations, Inc. (USA)
LifeSign LLC (USA)
Nanogen Inc. (USA)
Ortho-Clinical Diagnostics, Inc. (USA)
Oxis International, Inc. (USA)
Prognostix, Inc. (USA)
Response Biomedical Corp. (Canada)
Roche Diagnostics Corp. (USA)
Siemens Healthcare Diagnostics, Inc. (USA)
11.GLOBAL MARKET ANALYTICS
12.THE UNITED STATES
Cardiovascular Diseases in the US: A Review
30% Fall in Number of Deaths due to Heart Diseases & Strokes Over Last Decade
Senior Citizens at High Risk for Heart Failure
CHF Biomarkers to Spearhead the US market
US Cardiac Markers POCT Segment
13.EUROPE
a.France
b.Germany
c.Italy
d.The United Kingdom
e.Rest of Europe
14.REST OF WORLD
Evolution of BNP Test market in Japan
Table 1: Region-Wise Incidence and Prevalence of Cardiovascular Diseases in
Table 2: Global Cardiac Biomarkers Market by Region for the Period 2007-2015 (Sales in US$ Million)
Table 3: Percentage Breakdown of Global Cardiac Biomarkers Market by Region for the Years 2009 &
Table 4: Global Cardiac Biomarkers Market in Laboratory Testing Sector by Region for the Period 2007-2015 (Sales in US$ Million)
Table 5: Percentage Breakdown of Global Cardiac Biomarkers Market in Laboratory Testing Sector by Region for the Years 2009 &
Table 6: Global Cardiac Biomarkers Market in Point-of-Care Testing Sector by Region for the Period 2007-2015 (Sales in US$ Million)
Table 7: Percentage Breakdown of Global Cardiac Biomarkers Market in Point-of-Care Testing Sector by Region for the Years 2009 &
Table 8: Global CK-MB Assay Test Market by Region for the Period 2007-2015 (Sales in US$ Million)
Table 9: Percentage Breakdown of Global CK-MB Assay Test Market by Region for the Years 2009 &
Table 10: Global Cardiac Troponin Assay Test Market by Region for the Period 2007-2015 (Sales in US$ Million)
Table 11: Percentage Breakdown of Global Cardiac Troponin Assay Test Market by Region for the Years 2009 &
Table 12: Global Myoglobin Assay Test Market by Region for the Period 2007-2015 (Sales in US$ Million)
Table 13: Percentage Breakdown of Global Myoglobin Assay Test Market by Region for the Years 2009 &
Table 14: Global BNP & NT pro-BNP Assay Test Market by Region for the Period 2007-2015 (Sales in US$ Million)
Table 15: Percentage Breakdown of Global BNP & NT pro-BNP Assay Test Market by Region for the Years 2009 &
Table 16: Market Shares of Leading AMI (Acute Myocardial Infarction) Diagnostics Manufacturer Revenues in the US –
Table 17: Market Shares of Leading CHF (Congestive Heart Failure) Diagnostics Manufacturer Revenues in the US –
Table 18: Market Shares of Leading Manufacturers in the Laboratory Testing Segment in the US –
Table 19: Cardiac Biomarkers Market by Segment in the US: 2007-2015 (Sales in US$ Million)
Table 20: Percentage Breakdown of Cardiac Biomarkers Market by Segment in the US for the Years 2009 &
Table 21: Cardiac Biomarkers Market by Test Type in the US: 2007-2015 (Sales in US$ Million)
Table 22: Percentage Breakdown of Cardiac Biomarkers Market by Test Type in the US for the Years 2009 &
Table 23: Cardiac Biomarkers Market by Region in Europe: 2007-2015 (Sales in US$ Million)
Table 24: Percentage Breakdown of Cardiac Biomarkers Market by Region in Europe for the Years 2009 &
Table 25: Cardiac Biomarkers Market by Segment in Europe: 2007-2015 (Sales in US$ Million)
Table 26: Percentage Breakdown of Cardiac Biomarkers Market by Segment in Europe for the Years 2009 &
Table 27: Cardiac Biomarkers Market by Assay Test Type in Europe: 2007-2015 (Sales in US$ Million)
Table 28: Percentage Breakdown of Cardiac Biomarkers Market by Assay Test Type in Europe for the Years 2009 &
Table 29: Cardiac Biomarkers Market by Segment in France: 2007-2015 (Sales in US$ Million)
Table 30: Percentage Breakdown of Cardiac Biomarkers Market by Segment in France for the Years 2009 &
Table 31: Cardiac Biomarkers Market by Segment in Germany: 2007-2015 (Sales in US$ Million)
Table 32: Percentage Breakdown of Cardiac Biomarkers Market by Segment in Germany for the Years 2009 &
Table 33: Cardiac Biomarkers Market by Segment in Italy: 2007-2015 (Sales in US$ Million)
Table 34: Percentage Breakdown of Cardiac Biomarkers Market by Segment in Italy for the Years 2009 &
Table 35: Cardiac Biomarkers Market by Segment in the UK: 2007-2015 (Sales in US$ Million)
Table 36: Percentage Breakdown of Cardiac Biomarkers Market by Segment in the UK for the Years 2009 &
Table 37: Cardiac Biomarkers Market by Segment in Rest of Europe: 2007-2015 (Sales in US$ Million)
Table 38: Percentage Breakdown of Cardiac Biomarkers Market by Segment in Rest of Europe for the Years 2009 &
Table 39: Cardiac Biomarkers Market by Segment in Rest of World: 2007-2015 (Sales in US$ Million)
Table 40: Percentage Breakdown of Cardiac Biomarkers Market by Segment in Rest of World for the Years 2009 &
Table 41: Cardiac Biomarkers Market by Assay Test Type in Rest of World: 2007-2015 (Sales in US$ Million)
Table 42: Percentage Breakdown of Cardiac Biomarkers Market by Assay Test Type in Rest of World for the Years 2009 &
Companies Profiled