Chapter- 1: INTRODUCTION
STUDY GOALS AND OBJECTIVES 1
REASONS FOR DOING THE STUDY 1
SCOPE OF REPORT 1
INTENDED AUDIENCE 2
METHODOLOGY AND INFORMATION SOURCES 2
ANALYST CREDENTIALS 3
RELATED BCC REPORTS 3
BCC ONLINE SERVICES 3
DISCLAIMER 4
Chapter-2: SUMMARY
SUMMARY TABLE GLOBAL MARKET FOR CELL AND TISSUE ANALYSIS PRODUCTS, BY SEGMENT, THROUGH 2014 ($ MILLIONS) 5
SUMMARY FIGURE GLOBAL MARKET FOR CELL AND TISSUE ANALYSIS PRODUCTS, BY SEGMENT, 2008-2014 ($ MILLIONS) 5
SUMMARY (CONTINUED) 6
Chapter-3: OVERVIEW
GENERAL DESCRIPTION 7
DEFINITIONS 7
Antibody 8
Antigen 8
Apoptosis 8
Biomarker 8
Biospecimen 8
Cell 9
TABLE 1 CHARACTERISTICS OF PROKARYOTIC AND EUKARYOTIC CELLS 9
TABLE 2 CHARACTERISTICS OF PLANT AND ANIMAL CELLS 9
TABLE 2 (CONTINUED) 10
Cell-Based Assay 10
Epitope 10
Flow Cytometer 10
FIGURE 1 MAIN COMPONENTS OF A FLOW CYTOMETER 11
Fluorescence Activated Cell Sorting 12
High-Content Screening 12
Hybridoma 12
Immunohistochemistry 12
In vitro Culture 13
Isotype 13
Laser Microdissection 13
Monoclonal (Antibody) 14
Polyclonal (Antibody) 14
Primary Antibody 14
Primary Cells 14
Secondary Antibody 14
Tissue 15
TABLE 3 MAJOR TISSUE TYPES AND CONSTITUENT CELLS 15
Tissue Microarray 15
INDUSTRY DEFINITION 16
INDUSTRY BREAKDOWN 16
Biospecimens 16
TABLE 4 MAJOR BIOSPECIMENS USED IN RESEARCH AND DRUG DEVELOPMENT 17
TABLE 5 BIOSPECIMENS LIFECYCLE 17
Cell and Tissue Separation Products 18
TABLE 6 MAJOR TYPES OF CELL AND TISSUE SEPARATION PRODUCTS USED IN RESEARCH AND DRUG DEVELOPMENT 18
Cell and Tissue Characterization Products 18
TABLE 7 APPLICATIONS OF CELL AND TISSUE CHARACTERIZATION PRODUCTS IN RESEARCH AND DRUG DEVELOPMENT 19
PRODUCT BREAKDOWN 19
Biospecimens 19
History 19
Types of Biospecimens 19
Tissue Microarray 20
History 20
Frozen Arrays 20
FFPE Arrays 21
TMA Applications 21
Cell and Tissue Dissociation 22
Enzymatic Dissociators 22
TABLE 8 COMMON ENZYMES USED FOR CELL AND TISSUE DISSOCIATION 22
Mechanical Dissociators 22
Bead Method 23
Sonication 23
Pressure Homogenizing 23
Rotor-stator Homogenizing 23
Manual Grinding 24
Blade Homogenizing 24
Magnetic Cell Separation Technology 24
Technology 24
Laser Microdissection 25
History 25
LMD Applications 25
LMD Platforms 26
Laser Microdissection and Pressure Catapulting 26
Fusion Microdissection 26
Flow Cytometry 26
History 26
Cytometer Types 27
Analyzers 27
Sorters 27
Detection 27
Clinical Applications 28
Research Applications 28
Research Antibodies 28
History 28
Antibody Types 29
Primary Antibodies 29
Secondary Antibodies 29
Isotype Controls 30
Antibody Specifications 30
Host 30
TABLE 9 HOST SPECIES USED IN GENERATING RESEARCH ANTIBODIES (SPECIES) 30
Class/Isotype 30
Target Species (Reactivity) 31
Label 31
TABLE 10 COMMON ANTIBODY LABELS (TYPE) 31
Cell-Based Assays 31
History 31
Applications of Cell-Based Assays 32
Types of Cell-Based Assays 32
Signaling Assays 32
Cell Viability/Death Assays 32
Cell Proliferation Assays 33
Cell Migration Assays 33
High-Content Screening 34
History 34
HCS Applications 34
HCS Instrumentation 35
Confocal Machines 35
Non-confocal Machines 35
REGULATORY ISSUES 35
HISTORY 35
Biomedical Tissue Services 36
American Tissue 37
Willed Body Program 37
Body World 37
Bodies...the Exhibition 38
BIOSPECIMEN REGULATORY STRUCTURE 38
Federal Regulations 38
Current Good Tissue Practices 38
TABLE 11 INTERNATIONAL REGULATORY RULES & RULINGS GUIDING THE ACCESS/USE OF HUMAN TISSUE IN RESEARCH AND DRUG DISCOVERY, 2001-2009 39
State Regulations 39
Chapter-4: INDUSTRY STRUCTURE AND COMPETITIVE ANALYSIS
INDUSTRY PARTICIPANTS 40
TISSUE MICROARRAYS 40
TABLE 12 MAJOR COMPANIES IN THE TISSUE MICROARRAY MARKET 40
TABLE12 (CONTINUED) 41
CELL SEPARATION PRODUCTS 41
TABLE 13 MAJOR COMPANIES IN THE CELL SEPARATION PRODUCT MARKET 41
TABLE 13 (CONTINUED) 42
RESEARCH ANTIBODIES 42
TABLE 14 MAJOR COMPANIES IN THE RESEARCH ANTIBODIES MARKET 43
TABLE 15 COMPANIES IN THE GMP ANTIBODY PRODUCTION MARKET 43
TABLE 15 (CONTINUED) 44
TABLE 15 (CONTINUED) 45
TABLE 16 COMPANIES IN THE GMP ANTIBODY PRODUCTION MARKET, BY LOCATION, 2009 45
TABLE 16 (CONTINUED) 46
CELL-BASED ASSAYS 46
TABLE 17 COMPANIES IN THE CELL-BASED ASSAY PRODUCT MARKET 47
HIGH-CONTENT SCREENING PRODUCTS 47
TABLE 18 COMPANIES IN THE HIGH CONTENT SCREENING INSTRUMENTATION PRODUCT MARKET 48
MARKET SHARES 48
BIOSPECIMENS 48
TABLE 19 MARKET SHARE OF COMMERCIAL BIOSPECIMEN VENDORS 2008 ($ MILLION, %) 48
LASER MICRODISSECTION 49
TABLE 20 MARKET SHARE OF COMMERCIAL LASER MICRODISSECTION MARKET LEADERS 2009 ($ MILLION, %) 49
FLOW CYTOMETRY 50
TABLE 21 MARKET SHARE OF COMMERCIAL FLOW CYTOMETRY MARKET LEADERS, 2008 ($ MILLIONS) 50
RESEARCH ANTIBODIES 50
TABLE 22 MARKET SHARE OF COMMERCIAL RESEARCH ANTIBODY MARKET LEADERS, 2008 ($ MILLIONS) 51
HIGH CONTENT SCREENING/CELL-BASED ASSAYS 51
TABLE 23 MARKET SHARE OF COMMERCIAL HIGH CONTENT SCREENING AND CELL-BASED ASSAY INSTRUMENTATION MARKET LEADERS, 2009 ($ MILLIONS) 52
TABLE 24 MARKET SHARE OF COMMERCIAL HIGH CONTENT SCREENING AND CELL-BASED ASSAY REAGENT MARKET LEADERS, 2009 ($ MILLIONS) 52
MERGERS, ACQUISITIONS, STRATEGIC ALLIANCES & PARTNERSHIPS 53
BIOSPECIMENS 53
TABLE 25 MAJOR BIOSPECIMEN INDUSTRY EVENTS, 2005-2009 53
LASER MICRODISSECTION 54
TABLE 26 MAJOR LASER MICRODISSECTION INDUSTRY EVENTS, 2004-2009 54
FLOW CYTOMETRY 55
TABLE 27 MAJOR FLOW CYTOMETRY INDUSTRY EVENTS, 2005-2009 55
RESEARCH ANTIBODIES 55
TABLE 28 MAJOR RESEARCH ANTIBODY INDUSTRY EVENTS, 2005-2009 56
Notable Developments 57
HIGH CONTENT SCREENING 57
TABLE 29 MAJOR HIGH CONTENT SCREENING INDUSTRY EVENTS, 2004-2009 57
TABLE 29 (CONTINUED) 58
Chapter-5: CELL AND TISSUE ANALYSIS TECHNOLOGIES
INTRODUCTION 59
BIOSPECIMEN TECHNOLOGIES 59
TABLE 30 NEW PRODUCTS FROM BIOSPECIMEN MARKET COMPANIES 59
TABLE 30 (CONTINUED) 60
TABLE 30 (CONTINUED) 61
TISSUE MICROARRAYS 61
TABLE 31 PRODUCT SPECIFICATIONS OF TISSUE MICROARRAYS 62
FIGURE 2 FLOW DIAGRAM FOR TISSUE MICROARRAY PRODUCTION 63
Tissue Microarray Production 64
Types of Tissue Microarrays 64
Frozen Tissue Arrays 64
FFPE Arrays 65
TABLE 32 COMPARISON OF THE MAIN TYPES OF TISSUE MICROARRAY FORMATS 66
Multi-sample Arrays 66
Progression Arrays 67
Prognosis Arrays 67
Applications of TMA 67
TABLE 33 EXAMPLE APPLICATIONS OF DIFFERENT TISSUE MICROARRAY PREPARATIONS 67
TABLE 33 (CONTINUED) 68
TABLE 34 COMMMON DISEASED TISSUES AVAILABLE IN TISSUE MICROARRAY FORMAT 68
TABLE 34 (CONTINUED) 69
New Developments in Tissue Microarray Technology 69
TABLE 35 TISSUE MICROARRAY, TECHNOLOGY DEVELOPMENT 70
Matrix Assembly 71
TMA Content 71
TMA Analysis Software 72
TABLE 36 COMPARISON OF TISSUE MICROARRAY ANALYSIS SOFTWARE PACKAGES 73
TABLE 36 (CONTINUED) 74
CELL SEPARATION TECHNOLOGIES 75
MECHANICAL AND ENZYMATIC SEPARATION 75
Neural Stem Cells 75
Neural Tissue 76
Magnetic Separation 76
Positive Selection 77
Negative Selection 77
Multi-step Selection 77
TABLE 37 NEW MAGNETIC CELL SEPARATION PRODUCTS 77
TABLE 37 (CONTINUED) 78
Laser Microdissection 79
Platforms 79
LMPC 79
Fusion Microdissection 79
Microscopes, Objectives, Stages and Software 79
TABLE 38 CURRENT LASER MICRODISSECTION INSTRUMENTS 80
New Developments 80
Live Cell Microdissection 80
Remote Operation 81
Flow Cytometry 81
TABLE 39 COMMONLY USED FLUORESCENCE LABELS USED IN FLOW CYTOMETRY 81
TABLE 39 (CONTINUED) 82
Cytometer Types 82
TABLE 40 NEW INSTRUMENTATION PRODUCTS FROM FLOW CYTOMETRY COMPANIES 83
TABLE 40 (CONTINUED) 84
Alternative Technologies 84
Imaging Cytometers 84
Laser Scanning Cytometers 84
TABLE 41 NEW PRODUCTS FROM FLOW CYTOMETRY COMPANIES 85
New Developments 85
Benchtop Cytometers 85
Multi-parametric Analyses 85
CELL AND TISSUE ANALYSIS TECHNOLOGIES 86
RESEARCH ANTIBODIES 86
FIGURE 3 SCHEMATIC PRODUCTION OF MONOCLONAL AND POLYCLONAL ANTIBODIES 86
New Developments 87
Stem Cell Antibodies 87
Modification-state Specific Antibodies 87
New Fluorophores 88
High-Content Screening 88
FIGURE 4 BASIC SCHEMATIC OF A TYPICAL HIGH CONTENT SCREENING INSTRUMENT 88
HCS Instrumentation 89
Confocal Instruments 89
Image Sectioning 89
TABLE 42 FEATURES OF COMMON CONFOCAL HCS INSTRUMENTATION 90
Widefield Instruments 90
Illumination Sources 91
Autofocus 91
TABLE 43 FEATURES OF COMMON WIDEFIELD HCS INSTRUMENTATION 92
Software 92
HCS Applications 92
Profiling Studies 93
Screening Studies 93
New Developments 93
TABLE 44 NEW PRODUCTS FROM HCS COMPANIES 94
Chapter-6: PATENT LANDSCAPE
INTRODUCTION 95
CTA INDUSTRY 95
IMPORTANT CONCEPTS 95
Priority Dates 95
Patent Cooperation Treaty 96
IPC Codes 96
METHODOLOGY 96
PATENTS FOR BIOSPECIMEN VENDORS 97
TABLE 45 NUMBER OF U.S. PATENTS FOR MAJOR BIOSPECIMEN VENDORS, 2009 (NO. OF PATENTS, % OF PATENTS) 98
TABLE 46 NUMBER OF INTERNATIONAL PATENTS FOR MAJOR BIOSPECIMEN VENDORS, THROUGH 2009 (NO. OF PATENTS, % OF PATENTS) 98
TISSUE MICROARRAY PATENTS 99
TABLE 47 PATENT PUBLICATIONS FOR TISSUE MICROARRAY TECHNOLOGIES, BY YEAR, 2001-2009 (NO. OF PATENTS) 99
TABLE 48 MAJOR PATENT ASSIGNEES FOR TISSUE MICROARRAY TECHNOLOGIES, 2001-2009 (AS OF JUNE 2009) 99
TABLE 48 (CONTINUED) 100
TABLE 49 MAJOR IPC CLASSES FOR TISSUE MICROARRAY PATENTS, 2001-2009 (NO. OF PATENTS) 100
SUMMARY 101
PATENTS FOR CELL SEPARATION PRODUCT COMPANIES 102
TABLE 50 NUMBER OF U.S. PATENTS FOR MAJOR CELL SEPARATION PRODUCT COMPANIES, AS OF JUNE 1, 2009 (NO. OF PATENTS, PERCENT OF PATENTS) 103
TABLE 51 NUMBER OF INTERNATIONAL PATENTS FOR MAJOR CELL SEPARATION PRODUCT COMPANIES, AS OF JUNE 1, 2009 (NO. OF PATENTS, PERCENT OF PATENTS) 103
LASER MICRODISSECTION PATENTS 104
TABLE 52 PATENT PUBLICATIONS FOR LASER MICRODISSECTION TECHNOLOGIES, BY YEAR, 1999-2009 (NO. OF PATENTS) 104
TABLE 53 MAJOR PATENT ASSIGNEES FOR LASER MICRODISSECTION TECHNOLOGIES, 1999-2009 (NO. OF PATENTS) 105
TABLE 54 MAJOR IPC CLASSES FOR LASER MICRODISSECTION PATENTS, 1999-2009 (NO. OF PATENTS) 106
FLOW CYTOMETRY PATENTS 106
TABLE 55 PATENT PUBLICATIONS FOR FLOW CYTOMETRY TECHNOLOGIES, BY YEAR, 1999-2009 (NO. OF PATENTS) 107
TABLE 56 MAJOR PATENT ASSIGNEES FOR FLOW CYTOMETRY TECHNOLOGIES, 2001-2009 (NO. OF PATENTS) 107
TABLE 57 NUMBER OF U.S. PATENTS FOR MAJOR FLOW CYTOMETRY COMPANIES, 1971-2009 (NO. OF PATENTS, PERCENT OF PATENTS) 108
TABLE 58 MAJOR IPC CLASSES FOR FLOW CYTOMETRY PATENTS, 2001-2009 (NO. OF PATENTS) 109
SUMMARY 109
PATENTS FOR CELL AND TISSUE ANALYSIS COMPANIES 110
RESEARCH ANTIBODY PATENTS 110
TABLE 59 NUMBER OF ANTIBODY-RELATED PATENTS FOR MAJOR RESEARCH ANTIBODY COMPANIES, AS OF JUNE 1 2009 (NO. OF PATENTS) 111
Licensing 111
HIGH CONTENT SCREENING PATENTS 112
TABLE 60 CELLOMICS PATENTS IN THE HIGH CONTENT SCREENING INDUSTRY 112
TABLE 61 PATENT PUBLICATIONS RELATING TO HIGH CONTENT SCREENING, BY YEAR, 2004-2009 (NO. OF PATENTS) 113
TABLE 62 MAIN INDUSTRY SEGMENT OF HIGH CONTENT SCREENING PATENT ASSIGNEES, 2004-2009 113
CELL-BASED ASSAY PATENTS 114
TABLE 63 PATENT PUBLICATIONS RELATING TO CELL-BASED ASSAYS, BY YEAR, 2001-2009 (NO. OF PATENTS) 114
TABLE 64 MAIN INDUSTRY SEGMENT OF CELL-BASED ASSAY PATENT ASSIGNEES, 2001-2009 (%) 115
Chapter-7: END USERS
INTRODUCTION 116
TABLE 65 CELL AND TISSUE ANALYSIS PRODUCT END-USER INDUSTRIES 116
TABLE 65 (CONTINUED) 117
ACADEMIC RESEARCH 117
TABLE 66 NATIONAL INSTITUTES OF HEALTH BUDGET, THROUGH 2009 ($ BILLIONS) 118
TABLE 67 NATIONAL SCIENCE FOUNDATION BUDGET, THROUGH 2009 ($ BILLIONS) 118
RESEARCH UNIVERSITIES 119
TABLE 68 TOP 20 U.S. RESEARCH UNIVERSITIES RECEIVING FEDERAL SUPPORT, 2006 ($ MILLIONS) 119
TABLE 69 FEDERAL RESEARCH SUPPORT GROWTH RATES FOR THE TOP 20 FEDERALLY FUNDED U.S. RESEARCH UNIVERSITIES, THROUGH 2006 ($ MILLIONS, % CAGR) 120
TABLE 70 HIGHEST ANNUAL LIFE SCIENCES EXPENDITURES FOR THE TOP 20 FEDERALLY FUNDED U.S. RESEARCH UNIVERSITIES, 2006 ($ MILLIONS) 121
Translational Research 121
TABLE 71 MAJOR U.S. CLINICAL AND TRANSLATIONAL SCIENCE AWARD (CTSA) CENTERS, BY LOCATION, 2009 122
TABLE 71 (CONTINUED) 123
TABLE 71 (CONTINUED) 124
TABLE 71 (CONTINUED) 125
Government Laboratories 125
TABLE 72 LIST OF NIH RESEARCH LABS 125
TABLE 73 NIH INTRAMURAL RESEARCH BUDGET, THROUGH 2009 ($ MILLIONS) 126
Nonprofit Research Institutes 126
TABLE 74 LIST OF THE LARGEST U.S. NONPROFIT RESEARCH INSTITUTES, 2008 ($ MILLION) 126
TABLE 74 (CONTINUED) 127
BIOPHARMACEUTICAL 127
Drug Development Process 127
Biotechnology Industry 128
TABLE 75 ANNUAL BIOTECHNOLOGY R&D EXPENDITURES OF SELECT INTERNATIONAL COUNTRIES ($ BILLIONS) 129
TABLE 76 LIST OF NOTABLE BIOTECHNOLOGY INDUSTRY COMPANIES 129
Pharmaceutical Industry 130
TABLE 77 LIST OF NOTABLE PHARMACEUTICAL INDUSTRY COMPANIES 130
TABLE 78 BIOPHARMACEUTICAL R&D SPENDING, THROUGH 2009 ($ BILLIONS) 131
HEALTHCARE/CLINICAL 131
Research Hospitals 131
INTERNATIONAL ASPECTS 131
Europe 131
TABLE 79 TOTAL RESEARCHERS IN EUROPEAN COUNTRIES BY PERFORMANCE SECTOR, 2008 (#, X1,000) 132
GLOBAL MARKET 132
Trends in U.S. Research and Development 132
TABLE 80 U.S. EXPENDITURES ON R&D FINANCING BY SECTOR, THROUGH 2014 ($ BILLIONS) 133
TABLE 81 U.S. GROSS DOMESTIC EXPENDITURE ON R&D (GERD) FINANCING BY SECTOR, THROUGH 2014 (%) 133
Trends in International Research and Development 134
TABLE 82 GROSS DOMESTIC EXPENDITURE ON R&D (GERD) BY THE PRIVATE BUSINESS SECTOR IN EUROPEAN COUNTRIES, 2000-2008 (%) 134
TABLE 83 GROSS DOMESTIC EXPENDITURE ON R&D (GERD) BY THE GOVERNMENT SECTOR IN EUROPEAN COUNTRIES, 2000-2008 (%) 135
MARKETS BY PRODUCTS 135
Biospecimens 135
Tissue Microarray Use 136
TABLE 84 PUBMED INDEXED SCIENTIFIC PUBLICATIONS USING TISSUE MICROARRAY, 1998-2009 136
TABLE 85 CLINICAL TRIALS USING TISSUE MICROARRAY, 2001-2009 136
TABLE 85 (CONTINUED) 137
TABLE 86 PROJECTED GLOBAL SALES OF BIOSPECIMENS, THROUGH 2014 (% MILLIONS) 137
Cell Separation Products 137
TABLE 87 PROJECTED GLOBAL SALES OF CSP, THROUGH 2014 ($ MILLIONS) 138
Laser Microdissection 138
TABLE 88 PUBMED INDEXED SCIENTIFIC PUBLICATIONS USING LASER CAPTURE MICRODISSECTION, 1998-2009 139
TABLE 89 CLINICAL TRIALS USING LASER MICRODISSECTON, 1999-2009 139
TABLE 90 PROJECTED GLOBAL SALES OF LMD, THROUGH 2014 ($ MILLIONS) 140
Flow Cytometry 140
TABLE 91 PUBMED INDEXED SCIENTIFIC PUBLICATIONS USING FLOW CYTOMETRY OR FLUORESCENCE ACTIVATED CELL SORTING, 1998-2009 140
TABLE 92 CLINICAL TRIALS USING FLOW CYTOMETRY FLUORESCENCE ACTIVATED CELL SORTING, BY LOCATION, 2009 (NO. OF TRIALS) 141
TABLE 93 CLINICAL TRIALS USING FLOW CYTOMETRY OR FLUORESCENCE ACTIVATED CELL SORTING, BY FUNDING SOURCE, 2002-2009 142
TABLE 94 CLINICAL TRIALS USING FLOW CYTOMETRY OR FLUORESCENCE ACTIVATED CELL SORTING, BY CONDITION CATEGORY, 2009 142
TABLE 95 PROJECTED GLOBAL SALES OF THE FLOW CYTOMETRY INDUSTRY THROUGH 2014 ($ MILLIONS) 143
Cell and Tissue Characterization Products 143
TABLE 96 PROJECTED GLOBAL SALES OF CTC PRODUCTS, THROUGH 2014 ($ MILLIONS) 143
Research Antibodies 144
TABLE 97 PROJECTED GLOBAL SALES OF CTC PRODUCTS, THROUGH 2014 ($ MILLIONS) 144
HCS/CBA 144
TABLE 98 PROJECTED GLOBAL SALES OF CTC PRODUCTS, THROUGH 2014 ($ MILLIONS) 144
TABLE 99 HCS/CBA PRODUCT SEGMENTS, 2009 (%) 145
MARKETS BY END-USER SEGMENTS 145
TABLE 100 GLOBAL END-USER MARKETS FOR CELL AND TISSUE ANALYSIS PRODUCTS, THROUGH 2014 ($ MILLIONS) 146
Academic Research 146
TABLE 101 ACADEMIC RESEARCH END-USER SEGMENTS, 2009 (%) 146
TABLE 102 GLOBAL MARKETS FOR CELL AND TISSUE ANALYSIS PRODUCTS IN ACADEMIC RESEARCH, THROUGH 2014 ($ MILLIONS) 147
Biopharmaceutical 147
TABLE 103 BIOPHARMACEUTICAL END-USER SEGMENTS, 2009 (%) 147
TABLE 104 MARKETS FOR CELL AND TISSUE ANALYSIS PRODUCTS IN BIOPHARMACEUTICAL RESEARCH, THROUGH 2014 ($ MILLIONS) 148
TABLE 105 OTHER MARKETS FOR CELL AND TISSUE ANALYSIS PRODUCTS, THROUGH 2014 ($ MILLIONS) 149
GEOGRAPHIC MARKETS 149
General Trends 149
TABLE 106 REAL GDP GROWTH RATES IN THE UNITED STATES, 2005-2010 (PERCENT CHANGE OVER PREVIOUS YEAR) 150
TABLE 107 REAL GDP GROWTH RATES IN EUROPEAN COUNTRIES, 2005-2010 (PERCENT CHANGE OVER PREVIOUS YEAR) 150
Global Market Trends 151
TABLE 108 GEOGRAPHIC MARKETS FOR CELL AND TISSUE ANALYSIS PRODUCTS, THROUGH 2014 ($ MILLIONS) 151
Biospecimens 151
TABLE 109 BIOSPECIMEN GEOGRAPHIC MARKET SHARES, 2009 AND 2014 (PERCENT OF GLOBAL SALES) 152
TABLE 110 GEOGRAPHIC MARKETS FOR BIOSPECIMENS, THROUGH 2014 ($ MILLIONS) 152
CSP 153
TABLE 111 CELL SEPARATION PRODUCT GEOGRAPHIC MARKET SHARES, 2009 AND 2014 (PERCENT OF GLOBAL SALES) 153
TABLE 112 GEOGRAPHIC MARKETS FOR CELL SEPARATION PRODUCTS, THROUGH 2014 ($ MILLIONS) 154
CTC Products 154
TABLE 113 CTC PRODUCT GEOGRAPHIC MARKET SHARES, 2009, AND 2014 (PERCENT OF GLOBAL SALES) 154
TABLE 114 GEOGRAPHIC MARKETS FOR CELL AND TISSUE CHARACTERIZATION PRODUCTS, THROUGH 2014 ($ MILLIONS) 155
Chapter-8: COMPANY PROFILES
BIOSPECIMEN VENDORS (BSV) 156
TABLE 115 PRODUCTS AND SERVICES OFFERED BY BIOSPECIMEN VENDORS (BSV), 2009 (X REPRESENTS PRODUCT OR SERVICE PROVIDED) 156
AMERICAN TYPE CULTURE COLLECTION (ATCC) 156
ANALYTICAL BIOLOGICAL SERVICES, INC. 157
ASTERAND PLC. 158
BIOCHAIN INSTITUTE, INC. 159
BIOSERVE BIOTECHNOLOGIES LTD. 159
CAPITAL BIOSCIENCES, INC. 160
CELLECTA, INC. 161
CURELINE, INC. 161
CYBRDI, INC. 162
FOLIO BIOSCIENCES 163
ILSBIO, LLC. 163
LIFESPAN BIOSCIENCES, INC. 164
PROMEDDX, LLC 165
U.S. BIOMAX, INC. 166
CELL SEPARATION PRODUCT (CSP) COMPANIES 167
TABLE 116 PRODUCTS AND SERVICES OFFERED BY CELL SEPARATION PRODUCT (CSP) COMPANIES, 2009 (X REPRESENTS PRODUCT OR SERVICE PROVIDED) 167
ACCURI CYTOMETERS, INC. 167
BECKMAN COULTER, INC. 168
BD BIOSCIENCES 168
CARL ZEISS MICROIMAGING, GMBH 169
LEICA MICROSYSTMES, GMBH 170
MILLIPORE 170
MILTENYI BIOTEC 171
MDS ANALYTICAL TECHNOLOGIES 172
MOLECULAR MACHINES & INDUSTRIES, GMBH 172
PARTEC, GMBH 173
STEM CELL TECHNOLOGIES 173
WORTHINGTON BIOCHEMCIAL CORPORATION 174
CELL AND TISSUE CHARACTERIZATION COMPANIES 175
TABLE 117 PRODUCTS AND SERVICES OFFERED BY CELL & TISSUE CHARACTERIZATION COMPANIES, 2009 (X REPRESENTS PRODUCT OR SERVICE PROVIDED) 175
ABCAM, PLC. 175
CELL SIGNALING TECHNOLOGY, INC. 176
CELLUMEN, INC. 176
EBIOSCIENCE, INC. 177
GE HEALTHCARE BIOSCIENCES 177
INVITROGEN CORPORATION 178
MBL INTERNATIONAL 179
PERKINELMER, INC. 179
PLATYPUS TECHNOLOGIES, LLC 180
PROMEGA CORPORATION 180
ROCHE APPLIED SCIENCE 180
SIGMA-ALDRICH, INC. 181
THERMO FISHER SCIENTIFIC, INC. 182
APPENDIX: GLOSSARY 183
