Downstream Processing in Biopharmaceuticals

1 Table of Contents
1.1 List of Tables
1.2 List of Figures

2 Downstream Processing in Biopharmaceuticals - Introduction

3 Downstream Processing in Biopharmaceuticals - Market Overview
3.1 Overview of Biopharmaceuticals
3.1.1 Cytokines
3.1.2 Enzymes
3.1.3 Hormones
3.1.4 Clotting Factors
3.1.5 Vaccines
3.1.6 Monoclonal Antibodies
3.1.7 Cell Therapies
3.1.8 Antisense Drugs
3.1.9 Peptide Therapeutics
3.2 Overview of Downstream Processing in Biopharmaceuticals
3.2.1 A Typical Downstream Processing Operation
3.2.2 Major Check Points during Downstream Processing

4 Downstream Processing in Biopharmaceuticals - Role of Downstream Processing in the Biopharmaceutical Industry
4.1 Major Reagents, Reagent Suppliers and Reagents Market related to Downstream Process
4.1.1 Major Reagents
4.1.2 Reagent Suppliers
4.1.3 Reagent Market
4.2 Major Equipment Suppliers

5 Downstream Processing in Biopharmaceuticals - Downstream Processing Market for CMOs
5.1 Global CMO Market Overview
5.2 CMO Biopharmaceuticals Market Characterization
5.3 CMO Market Size for Downstream Processing

6 Downstream Processing in Biopharmaceuticals - Challenges and Unmet Needs in Downstream Bioprocess
6.1 Challenges
6.1.1 Chromatographic Capture
6.1.2 Reducing the Purification Steps
6.1.3 Titer Increment/Capacity Bottleneck
6.1.4 Virus Clearances
6.1.5 Scaling –Up
6.2 Unmet Needs
6.2.1 Unmet Medical Needs
6.2.2 Realistic Achievement of Economies of Scale
6.2.3 Technological Development of Disposables at Large Scale
6.2.4 Reagent Costs and their Effectiveness

7 Downstream Processing in Biopharmaceuticals - Emerging Technologies and their Implications
7.1 Single Use Technology/Disposable Technology
7.1.1 Advantages
7.1.2 Disadvantages
7.2 Multi-column Chromatography
7.2.1 Advantages
7.2.2 Disadvantages
7.3 Tangential Flow Filtration
7.3.1 Advantages
7.3.2 Disadvantages

8 Downstream Processing in Biopharmaceuticals - Industry Analysis
8.1 Key Drivers and Restraints
8.1.1 Key Drivers of Downstream Processing Market
8.1.2 Key Restraints of Downstream Processing Market
8.2 Porter's Five Forces Model for Industry Analysis
8.3 Major Events and their Impact – Analysis

9 Downstream Processing in Biopharmaceuticals - Competitive Landscape
9.1 Market Dynamics of Downstream Processing and Impact
9.1.1 Market Structure
9.2 Key Equipment Players
9.2.1 Pall Corporation
9.2.2 Millipore
9.2.3 Sartorius Stedim Biotech S.A.
9.3 Key Reagent Players
9.3.1 Life Technologies
9.3.2 Sigma Aldrich
9.4 Key CMO Players
9.4.1 Lonza
9.4.2 Boehringer Ingelheim
9.4.3 Diosynth Biotechnology

10 Downstream Processing in Biopharmaceuticals - Appendix
10.1 Market Definitions
10.2 Abbreviations
10.3 Bibliography
10.4 Research Methodology
10.4.1 Coverage
10.4.2 Secondary Research
10.4.3 Primary Research
10.4.4 Expert Panel Validation
10.5 Contact Us
10.6 Disclaimer

List of Tables

Table 1: Downstream Processing, Global, Cost Breakups of Upstream and Downstream Processing, 2011
Table 2: Downstream Processing, Global, Reagent Suppliers, 2011
Table 3: Downstream Processing, Global, Total Reagent Market for Downstream Processing, Revenue ($m), 2009–2011
Table 4: Downstream Processing, Global, Total Reagent Market for Downstream Processing, Revenue Forecast ($m), 2011–2018
Table 5: Downstream Processing, Global, Equipment Suppliers, 2011
Table 6: Downstream Processing, Global, CMO Biopharmaceutical Market, Revenue ($bn), 2008–2011
Table 7: Downstream Processing, Global, CMO Biopharmaceutical Market, Revenue Forecast ($bn), 2011–2018
Table 8: Downstream Processing, Global, Downstream Processing Market for CMOs, Revenue ($bn), 2009–2011
Table 9: Downstream Processing, Global, Downstream Processing Market for CMOs, Revenue ($bn), 2011–2018
Table 10: Downstream Processing, Key Equipment Players, Pall Corporation, Major M&A Deals, 2009–2012
Table 11: Downstream Processing, Key Equipment Players, EMD Millipore, Major M&A Deals, 2009–2010
Table 12: Downstream Processing, Key Equipment Players, Sartorius Stedim Biotech S.A, Major M&A Deals, 2008
Table 13: Downstream Processing, Key Reagent Players, Life Technologies, Major M&A Deals, 2009–2011
Table 14: Downstream Processing, Key Reagent Players, Sigma-Aldrich, Major M&A Deals, 2009–2012
Table 15: Downstream Processing, Key CMO Players, Lonza, Major M&A Deals, 2009–2010
Table 16: Downstream Processing, Key CMO Players, Boehringer Ingelhiem, Major M&A Deals, 2009–2011
Table 17: Downstream Processing, Key CMO Players, Diosynth Biotechnology, Major M&A Deals, 2009–2011

List of Figures

Figure 1: Downstream Processing, Global, Biopharmaceutical Types, 2011
Figure 2: Downstream Processing, Global, Overview of General Drug Development Process, 2011
Figure 3: Downstream Processing, Global, Process Steps, 2011
Figure 4: Downstream Processing, Global, Changing Distribution of Cost along with Yield Increment, 2011
Figure 5: Downstream Processing, Global, Yield Percentage vs Number of Purification Steps, 2011
Figure 6: Downstream Processing, Global, Cost Breakups of Upstream and Downstream Processing, 2011
Figure 7: Downstream Processing, Global, Total Reagent Market for Downstream Processing, Revenue ($m), 2009–2018
Figure 8: Downstream Processing, Global, CMO Biopharmaceutical Market, Revenue ($bn), 2008–2018
Figure 9: Downstream Processing, Global, Downstream Processing Market for CMOs, Revenue ($bn), 2009–2018
Figure 10: Downstream Processing, Global, Challenges, 2011
Figure 11: Downstream Processing, Global, Emerging Technologies and their Likely Adaptation, 2011
Figure 12: Downstream Processing, Global, Industry Analysis, Key Drivers and Restraints, 2011
Figure 13: Downstream Processing, Global, Industry Analysis, Porter's Five Forces Model, 2011
Figure 14: Downstream Processing, Global, Industry Analysis, Major Market Events and their Impact, 2011
Figure 15: Downstream Processing, Global, Industry Analysis, Market Dynamics, 2011
Figure 16: Downstream Processing, Key Equipment Players, Business Overview, Pall Corporation, 2011
Figure 17: Downstream Processing, Key Equipment Players, Business Overview, EMD Millipore, 2011
Figure 18: Downstream Processing, Key Equipment Players, Business Overview, Sartorius Stedim Biotech S.A, 2011
Figure 19: Downstream Processing, Key Reagent Players, Business Overview, Life Technologies, 2011
Figure 20: Downstream Processing, Key Reagent Players, Business Overview, Sigma-Aldrich, 2011
Figure 21: Downstream Processing, Key CMO Players, Business Overview, Lonza, 2011
Figure 22: Downstream Processing, Key CMO Players, Business Overview, Boehringer Ingelheim, 2011
Figure 23: Downstream Processing, Key CMO Players, Business Overview, Diosynth Biotechnology, 2011 54