CHAPTER ONE: INTRODUCTION.1
REASON FOR THE STUDY . 1
GOALS AND OBJECTIVES .. 1
AUDIENCE 1
SCOPE OF REPORT ...... 2
METHODOLOGY AND INFORMATION SOURCES .... 2
ANALYST CREDENTIALS ... 3
RELATED BCC REPORTS ... 3
BCC ONLINE SERVICES ..... 3
DISCLAIMER ... 4
CHAPTER TWO: SUMMARY .. 5
SUMMARY TABLE GLOBAL EXCIPIENTS MARKET BY MATERIAL
TYPE, THROUGH 2016 ($ MILLIONS) ..... 5
SUMMARY FIGURE GLOBAL EXCIPIENTS MARKET, 2011 AND 2016
($ MILLIONS) .... 6
SUMMARY (CONTINUED) .. 7
SUMMARY (CONTINUED) .. 8
SUMMARY (CONTINUED) .. 9
SUMMARY (CONTINUED) 10
CHAPTER THREE: OVERVIEW . 11
WHAT IS AN EXCIPIENT? 11
WHAT IS AN EXCIPIENT (CONTINUED) 12
WHAT IS AN EXCIPIENT? (CONTINUED) ..... 13
THE PHARMACEUTICALS INDUSTRY IN TURMOIL: 2000 TO
TODAY 13
THE KNOWLEDGE CRISIS ...... 14
THE KNOWLEDGE CRISIS (CONTINUED) ... 15
THE NEED FOR NEW EXCIPIENTS ..... 16
THE NEED FOR NEW EXCIPIENTS (CONTINUED) .. 17
A NOTE ABOUT DIRECT COMPRESSION .. 18
COPROCESSING IS SPLENDID, BUT IT IS NOT ENOUGH . 19
QBD AND THE GLOBAL SUPPLY CHAIN CRISIS: TWO TIDAL
WAVES 20
HOW AND WHY THE QUALITY APPROACH CAME TO PHARMA ... 20
HOW AND WHY THE QUALITY ...(CONTINUED) ...... 21
HOW AND WHY THE QUALITY ...(CONTINUED) ...... 22
HOW AND WHY THE QUALITY ...(CONTINUED) ...... 23
THE BASICS OF QBD . 23
THE BASICS OF QBD (CONTINUED) ..... 24
THE BASICS OF QBD IN 1,000 WORDS (CONTINUED) .... 25
THE BASICS OF QBD IN 1,000 WORDS (CONTINUED) .... 25
THE BASICS OF QBD IN 1,000 WORDS (CONTINUED) .... 26
THE GLOBAL SUPPLY CHAIN CRISIS 27
THE GLOBAL SUPPLY CHAIN CRISIS (CONTINUED) ..... 28
THE GLOBAL SUPPLY CHAIN CRISIS (CONTINUED) ..... 29
CHRONOLOGY, PART II (CONTINUED) . 30
CHRONOLOGY, PART II (CONTINUED) . 31
CHRONOLOGY, PART II (CONTINUED) . 32
IS THE WORKFORCE UP TO IT? ... 33
A NOTE ON THE RECESSION . 34
CHAPTER FOUR: GLOBAL EXCIPIENT MARKET: SEVERAL BASIC
FIGURES 35
FIGURE 1 GLOBAL EXCIPIENTS MARKET SHARE BY CATEGORY
OF MATERIAL, 2011 (%) ..... 35
FIGURE 2 GLOBAL EXCIPIENTS MARKET SHARE BY TYPE OF
ORGANIC CHEMICAL, 2011 (%) ..... 36
FIGURE 3 GLOBAL EXCIPIENTS MARKET SHARE BY TYPE OF
INORGANIC CHEMICAL, 2011 (%) .. 37
FIGURE 4 GLOBAL EXCIPIENTS MARKET SHARE BY TYPE OF USP
WATER, 2011 (%) .... 38
FIGURE 5 GLOBAL EXCIPIENTS MARKET SHARE BY FUNCTIONAL
USE, 2011 (%) .. 39
FIGURE 6 GLOBAL EXCIPIENTS MARKET SHARE BY TYPE OF
DELIVERY SYSTEM, 2011 (%) .. 40
FIGURE 7 GLOBAL EXCIPIENTS MARKET FOR FINISHED
PRODUCTS BY TYPE (RX AND OTC), 2011 (%) . 41
CHAPTER FIVE: CHEMICAL COMPOUNDS . 42
CHEMICAL COMPOUNDS 42
MARKET SIZE 42
TABLE 1 GLOBAL EXCIPIENTS MARKET VALUE BY MATERIAL
TYPE, THROUGH 2016 ($ MILLIONS) .. 43
TABLE 2 GLOBAL EXCIPIENTS MARKET VOLUME BY MATERIAL
TYPE, THROUGH 2016 (MILLION LBS) ...... 43
ORGANIC CHEMICALS ..... 44
SIZE OF THE MARKET FOR ORGANIC CHEMICALS 44
TABLE 3 GLOBAL ORGANIC CHEMICAL EXCIPIENTS MARKET
VALUE BY TYPE, THROUGH 2016 ($ MILLIONS) ... 44
TABLE 4 GLOBAL ORGANIC CHEMICAL EXCIPIENTS MARKET
VOLUME BY TYPE, THROUGH 2016 (MILLION LBS) ... 45
CARBOHYDRATES .. 45
Market Size ..... 45
TABLE 5 GLOBAL CARBOHYDRATE EXCIPIENTS MARKET BY
TYPE, THROUGH 2016 ($ MILLIONS) ... 45
TABLE 6 GLOBAL CARBOHYDRATES EXCIPIENTS MARKET BY
TYPE, THROUGH 2016 (MILLION LBS) 46
Celluloses . 46
Market Size . 46
TABLE 7 GLOBAL CELLULOSE EXCIPIENT MARKET BY TYPE,
THROUGH 2016 ($ MILLIONS) . 46
TABLE 8 GLOBAL CELLULOSE EXCIPIENT MARKET BY TYPE,
THROUGH 2016 (MILLION LBS) ..... 47
Microcrystalline Cellulose ...... 47
Market Size .. 47
TABLE 9 GLOBAL MCC EXCIPIENT MARKET, THROUGH 2016 ($
MILLIONS/MILLION LBS) 48
Cellulose Ethers . 48
Market Size .. 48
TABLE 10 GLOBAL CELLULOSE ETHER EXCIPIENT MARKET,
THROUGH 2016 ($ MILLIONS/MILLION LBS) . 48
Cellulose Esters . 49
Market Size .. 49
TABLE 11 GLOBAL CELLULOSE ESTER EXCIPIENT MARKET,
THROUGH 2016 ($ MILLIONS/MILLION LBS) . 49
Carboxymethyl Cellulose and Croscarmellose
Sodium ... 50
Market Size .. 50
TABLE 12 GLOBAL CMC AND CROSCARMELLOSE S MARKET,
THROUGH 2016 ($ MILLIONS/MILLION LBS) . 50
Sugars ...... 50
Market Size . 50
TABLE 13 VALUE OF GLOBAL SUGAR EXCIPIENT MARKET BY
TYPE, THROUGH 2016 ($ MILLIONS) ... 51
TABLE 14 VOLUME OF GLOBAL SUGAR EXCIPIENT MARKET BY
TYPE, THROUGH 2016 (MILLION LBS) ...... 51
Actual Sugars ..... 51
Market Size .. 52
TABLE 15 VALUE OF GLOBAL ACTUAL SUGAR EXCIPIENT
MARKET BY TYPE, THROUGH 2016 ($ MILLIONS) ...... 52
TABLE 16 VOLUME OF GLOBAL ACTUAL SUGAR EXCIPIENT
MARKET BY TYPE, THROUGH 2016 (MILLION LBS).... 52
Lactose .. 52
Market Size .... 53
TABLE 17 GLOBAL LACTOSE EXCIPIENT MARKET, THROUGH 2016
($ MILLIONS/MILLION LBS) ... 53
Sucrose .. 53
Market Size .... 54
TABLE 18 GLOBAL SUCROSE EXCIPIENT MARKET, THROUGH 2016
($ MILLIONS/MILLION LBS) ... 54
Dextrose (Glucose) .... 54
Market Size .... 54
TABLE 19 GLOBAL DEXTROSE (GLUCOSE) EXCIPIENT MARKET,
THROUGH 2016 ($ MILLIONS/MILLION LBS) . 55
Sugar Alcohols ... 55
Market Size .. 55
TABLE 20 VALUE OF GLOBAL SUGAR ALCOHOL (POLYOL)
EXCIPIENT MARKET BY TYPE, THROUGH 2016 ($ MILLIONS) ...... 55
TABLE 21 VOLUME OF GLOBAL SUGAR ALCOHOL (POLYOL)
EXCIPIENT MARKET BY TYPE, THROUGH 2016 (MILLION LBS) ... 56
Sorbitol .. 56
Market Size .... 56
TABLE 22 GLOBAL SORBITOL EXCIPIENT MARKET, THROUGH
2016 ($ MILLIONS/MILLION LBS) . 56
Mannitol 57
Market Size .... 57
TABLE 23 GLOBAL MANNITOL EXCIPIENT MARKET, THROUGH
2016 ($ MILLIONS/MILLION LBS) . 57
Other Sugar Alcohols 57
Market Size .... 58
TABLE 24 GLOBAL OTHER SUGAR ALCOHOL EXCIPIENT MARKET,
THROUGH 2016 ($ MILLIONS/MILLION LBS) . 58
Maltitol .. 58
Xylitol .... 58
Erythritol ..... 59
Isomalt .. 59
Tagatose 59
Trehalose ..... 59
Artificial Sweeteners 60
Market Size .. 60
TABLE 25 GLOBAL ARTIFICIAL SWEETENER EXCIPIENT MARKET,
THROUGH 2016 ($ MILLIONS/MILLION LBS) . 60
Aspartame ... 60
Neotame 61
Acesulfame-K...... 61
Saccharin ..... 61
Sucralose ...... 62
Starches .... 62
Market Size . 63
TABLE 26 VALUE OF THE GLOBAL STARCHES EXCIPIENT
MARKET BY TYPE, THROUGH 2016 ($ MILLIONS) 63
TABLE 27 VOLUME OF THE GLOBAL STARCHES EXCIPIENT
MARKET BY TYPE, THROUGH 2016 (MILLION LBS)..... 63
Dried Starch 63
Market Size .. 64
TABLE 28 GLOBAL DRIED STARCH EXCIPIENT MARKET,
THROUGH 2016 ($ MILLIONS/MILLION LBS) . 64
Modified Starch .. 64
Market Size .. 65
TABLE 29 GLOBAL MODIFIED STARCH EXCIPIENT MARKET,
THROUGH 2016 ($ MILLIONS/MILLION LBS) . 65
Converted Starch ...... 65
Market Size .. 65
TABLE 30 GLOBAL CONVERTED STARCH EXCIPIENT MARKET,
THROUGH 2016 ($ MILLIONS/MILLION LBS) . 66
PETROCHEMICALS 66
Market Size ..... 66
TABLE 31 VALUE OF THE GLOBAL PETROCHEMICAL EXCIPIENT
MARKET BY TYPE, THROUGH 2016 ($ MILLIONS) ...... 66
TABLE 32 VOLUME OF THE GLOBAL PETROCHEMICAL EXCIPIENT
MARKET BY TYPE, THROUGH 2016 (MILLION LBS)..... 67
Glycols ...... 67
Market Size . 67
TABLE 33 VALUE OF THE GLOBAL GLYCOL EXCIPIENT MARKET
BY TYPE, THROUGH 2016 ($ MILLIONS) ... 67
TABLE 34 VOLUME OF THE GLOBAL GLYCOL EXCIPIENT MARKET
BY TYPE, THROUGH 2016 (MILLION LBS) . 68
Polyethylene Glycol ... 68
Market Size .. 68
TABLE 35 GLOBAL PEG EXCIPIENT MARKET, THROUGH 2016 ($
MILLIONS/MILLION LBS) 69
Propylene Glycol 69
Market Size .. 69
TABLE 36 GLOBAL PG EXCIPIENT MARKET, THROUGH 2016 ($
MILLIONS/MILLION LBS) 69
Povidones . 70
Market Size . 70
TABLE 37 GLOBAL PVP EXCIPIENT MARKET, THROUGH 2016 ($
MILLIONS/MILLION LBS) 70
Mineral Hydrocarbons .. 70
Market Size . 71
TABLE 38 DOLLAR VALUE OF THE GLOBAL MINERAL
HYDROCARBON EXCIPIENT MARKET BY TYPE, THROUGH 2016
($ MILLIONS) .. 71
TABLE 39 VOLUME OF THE GLOBAL MINERAL HYDROCARBON
EXCIPIENT MARKET BY TYPE, THROUGH 2016 (MILLION LBS) ... 71
Petrolatum .. 72
Market Size .. 72
TABLE 40 GLOBAL PETROLATUM EXCIPIENT MARKET, THROUGH
2016 ($ MILLIONS/MILLION LBS) . 72
Mineral Waxes ... 72
Market Size .. 73
TABLE 41 GLOBAL MINERAL WAX EXCIPIENT MARKET, THROUGH
2016 ($ MILLIONS/MILLION LBS) . 73
Mineral Oils 73
Market Size .. 73
TABLE 42 GLOBAL MINERAL OIL EXCIPIENT MARKET, THROUGH
2016 ($ MILLIONS/MILLION LBS) . 74
Acrylic Polymers .... 74
Market Size . 74
TABLE 43 GLOBAL ACRYLIC EXCIPIENT MARKET, THROUGH 2016
($ MILLIONS/MILLION LBS) ... 75
Other Petrochemical Materials .. 75
Market Size . 75
TABLE 44 GLOBAL OTHER PETROCHEMICAL EXCIPIENT MARKET,
THROUGH 2016 ($ MILLIONS/MILLION LBS) . 75
Antimicrobials .... 76
Antioxidants 76
Dyes and Lakes .. 76
TABLE 45 SYNTHETIC COLORANTS IN PHARMACEUTICALS ..... 77
EDTA .... 77
Flavors .. 78
Glycine and Glycylglycine ...... 78
Vinyl Polymers ... 78
Silicones 79
Miscellaneous Synthetic Petrochemicals .... 79
OLEOCHEMICALS .. 79
Market Size ..... 80
TABLE 46 VALUE OF THE GLOBAL OLEOCHEMICAL EXCIPIENT
MARKET BY TYPE, THROUGH 2016 ($ MILLIONS) ...... 80
TABLE 47 VOLUME OF THE GLOBAL OLEOCHEMICAL EXCIPIENT
MARKET BY TYPE, THROUGH 2016 (MILLION LBS).... 80
Fatty Alcohols . 80
Market Size . 81
TABLE 48 GLOBAL FATTY ALCOHOL EXCIPIENT MARKET,
THROUGH 2016 ($ MILLIONS/MILLION LBS) . 81
Glycerin .... 81
Market Size . 81
TABLE 49 GLOBAL GLYCERIN EXCIPIENT MARKET, THROUGH
2016 ($ MILLIONS/MILLION LBS) . 82
Metal Stearates ..... 82
Market Size . 82
TABLE 50 GLOBAL METAL STEARATE EXCIPIENT MARKET,
THROUGH 2016 ($ MILLIONS/MILLION LBS) . 83
Other Oleochemicals ..... 83
Market Size . 83
TABLE 51 GLOBAL OTHER OLEOCHEMICAL EXCIPIENT MARKET,
THROUGH 2016 ($ MILLIONS/MILLION LBS) . 83
Natural Waxes ... 84
Beeswax 84
Candelilla Wax ... 84
Carnauba Wax .... 84
Cocoa and Shea Butters .. 84
Lanolin .. 84
Phospholipids ..... 85
Sodium Lauryl Sulfate ..... 85
Sorbitan 85
Synthetic Glyceryl Esters 85
Vegetable Oils .... 85
PROTEINS .. 86
Gelatin ...... 86
Market Size . 86
TABLE 52 GLOBAL PROTEINS (GELATIN) EXCIPIENT MARKET,
THROUGH 2016 ($ MILLIONS/MILLION LBS) . 87
Albumin 87
OTHER ORGANIC CHEMICALS . 87
TABLE 53 GLOBAL OTHER ORGANIC CHEMICAL EXCIPIENT
MARKET, THROUGH 2016 ($ MILLIONS/MILLION LBS) ... 88
Alcohols .... 88
Citric Acid 88
Lactic Acid 89
Polysaccharide Gums ... 89
Shellac ...... 89
INORGANIC CHEMICALS . 89
MARKET SIZE ... 89
TABLE 54 VALUE OF THE GLOBAL INORGANIC CHEMICAL
EXCIPIENT MARKET BY TYPE, THROUGH 2016 ($ MILLIONS) ...... 90
TABLE 55 VOLUME OF THE GLOBAL INORGANIC CHEMICAL
EXCIPIENT MARKET BY TYPE, THROUGH 2016 (MILLION LBS) ... 90
CALCIUM SALTS ..... 90
Market Size ..... 90
TABLE 56 VALUE OF THE GLOBAL CALCIUM SALT EXCIPIENT
MARKET BY TYPE, THROUGH 2016 ($ MILLIONS) 91
TABLE 57 VOLUME OF THE GLOBAL CALCIUM SALT EXCIPIENT
MARKET BY TYPE, THROUGH 2016 (MILLION LBS)..... 91
Calcium Phosphate 91
Market Size . 92
TABLE 58 GLOBAL CALCIUM PHOSPHATE EXCIPIENT MARKET,
THROUGH 2016 ($ MILLIONS/MILLION LBS) . 92
Calcium Carbonate 92
Market Size . 93
TABLE 59 GLOBAL CALCIUM CARBONATE EXCIPIENT MARKET,
THROUGH 2016 ($ MILLIONS/MILLION LBS) . 93
Calcium Sulfate ..... 93
Market Size . 93
TABLE 60 GLOBAL CALCIUM SULFATE EXCIPIENT MARKET,
THROUGH 2016 ($ MILLIONS/MILLION LBS) . 94
HALITES ..... 94
Market Size ..... 94
TABLE 61 GLOBAL HALITE EXCIPIENT MARKET, THROUGH 2016 ($
MILLIONS/MILLION LBS) 94
METAL OXIDES 95
Market Size ..... 95
TABLE 62 VALUE OF THE GLOBAL METAL OXIDE EXCIPIENT
MARKET BY TYPE, THROUGH 2016 ($ MILLIONS) 95
TABLE 63 VOLUME OF THE GLOBAL METAL OXIDE EXCIPIENT
MARKET BY TYPE, THROUGH 2016 (MILLION LBS)..... 95
Titanium Dioxide ... 96
Market Size . 96
TABLE 64 GLOBAL TIO2 EXCIPIENT MARKET, THROUGH 2016 ($
MILLIONS/MILLION LBS) 96
Iron Oxide 96
Market Size . 97
TABLE 65 GLOBAL IRON OXIDE EXCIPIENT MARKET THROUGH
2016 ($ MILLIONS/MILLION LBS) . 97
SILICATES .. 97
Market Size ..... 97
TABLE 66 VALUE OF THE GLOBAL SILICATES EXCIPIENT MARKET
BY TYPE, THROUGH 2016 ($ MILLIONS) .... 98
TABLE 67 VOLUME OF THE GLOBAL SILICATES EXCIPIENT
MARKET BY TYPE, THROUGH 2016 (MILLION LBS)..... 98
Silicon Dioxide 98
Market Size . 99
TABLE 68 GLOBAL SILICON DIOXIDE EXCIPIENT MARKET,
THROUGH 2016 ($ MILLIONS/MILLION LBS) . 99
Talc .... 99
Market Size . 99
TABLE 69 GLOBAL TALC EXCIPIENT MARKET, THROUGH 2016 ($
MILLIONS/MILLION LBS) ..... 100
Clay . 100
Market Size ...... 100
TABLE 70 GLOBAL CLAY EXCIPIENT MARKET, THROUGH 2016 ($
MILLIONS/MILLION LBS) ..... 100
OTHER INORGANIC CHEMICALS .. 101
Market Size ... 101
TABLE 71 GLOBAL OTHER INORGANIC CHEMICAL EXCIPIENT
MARKET, THROUGH 2016 ($ MILLIONS/MILLION LBS) . 101
USP WATER (PHARMACEUTICAL WATER) ... 101
MARKET SIZE . 102
TABLE 72 VALUE OF THE GLOBAL USP WATER EXCIPIENT
MARKET, THROUGH 2016 ($ MILLIONS) 102
TABLE 73 VOLUME OF THE GLOBAL USP WATER EXCIPIENT
MARKET, THROUGH 2016 (MILLION LBS) .... 102
WATER FOR INJECTIONS . 103
Market Size ... 103
TABLE 74 GLOBAL USP WFI EXCIPIENT MARKET, THROUGH 2016
($ MILLIONS/LBS MILLLIONS) ... 103
PURIFIED WATER. 103
Market Size ... 104
TABLE 75 GLOBAL USP PURIFIED WATER EXCIPIENT MARKET,
THROUGH 2016 ($ MILLIONS/LBS MILLLIONS) .. 104
FUNCTIONAL USES .... 104
TABLE 76 VALUE OF THE GLOBAL EXCIPIENT FUNCTIONAL USES
MARKET BY TYPE, THROUGH 2016 ($ MILLIONS) .... 105
TABLE 77 VOLUME OF THE GLOBAL EXCIPIENT FUNCTIONAL
USES MARKET BY TYPE, THROUGH 2016 (MILLION LBS) ..... 105
FILLERS 106
MARKET SIZE . 106
TABLE 78 VALUE OF THE GLOBAL EXCIPIENT FILLER MARKET BY
TYPE, THROUGH 2016 ($ MILLIONS) 106
TABLE 79 VOLUME OF THE GLOBAL EXCIPIENT FILLER MARKET
VOLUME BY TYPE, THROUGH 2016 (MILLION LBS) . 107
EMOLLIENTS ..... 107
MARKET SIZE . 107
TABLE 80 GLOBAL EMOLLIENTS EXCIPIENT MARKET, THROUGH
2016 ($ MILLIONS/MILLION LBS) ...... 108
VEHICLES .... 108
MARKET SIZE . 108
TABLE 81 VALUE OF THE GLOBAL VEHICLE EXCIPIENT MARKET
BY TYPE, THROUGH 2016 ($ MILLIONS) .. 109
TABLE 82 VOLUME OF THE GLOBAL VEHICLE EXCIPIENT
MARKET BY TYPE, THROUGH 2016 (MILLION LBS)... 109
COATINGS .... 110
MARKET SIZE . 110
TABLE 83 VALUE OF THE GLOBAL COATINGS EXCIPIENT MARKET
BY TYPE, THROUGH 2016 ($ MILLIONS) .. 110
TABLE 84 VOLUME OF THE GLOBAL COATINGS EXCIPIENT
MARKET BY TYPE, THROUGH 2016 (MILLION LBS)... 111
DISINTEGRANTS ...... 112
MARKET SIZE . 112
TABLE 85 VALUE OF THE GLOBAL SUPERDISINTEGRANT
EXCIPIENT MARKET BY TYPE, THROUGH 2016 ($ MILLIONS) ..... 112
TABLE 86 VOLUME OF THE GLOBAL SUPERDISINTEGRANT
EXCIPIENT MARKET BY TYPE, THROUGH 2016 (MILLION LBS) . 113
FLAVORS ...... 113
MARKET SIZE . 113
TABLE 87 VALUE OF THE GLOBAL FLAVORS EXCIPIENT MARKET
BY TYPE, THROUGH 2016 ($ MILLIONS) .. 114
TABLE 88 VOLUME OF THE GLOBAL FLAVORS EXCIPIENT
MARKET BY TYPE, THROUGH 2016 (MILLION LBS).. 114
TABLE 89 COMPARISON OF SEVERAL SWEETENERS TO SUCROSE
(%) ..... 115
TONICITY AGENTS .. 115
MARKET SIZE . 115
TABLE 90 GLOBAL TONICITY AGENT EXCIPIENT MARKET VALUE,
THROUGH 2016 ($ MILLIONS) ...... 115
TABLE 91 GLOBAL TONICITY AGENT EXCIPIENT MARKET
VOLUME, THROUGH 2016 (MILLION LBS) .... 116
COLORANTS 116
MARKET SIZE . 116
TABLE 92 GLOBAL COLORANTS EXCIPIENT MARKET BY TYPE,
THROUGH 2016 ($ MILLIONS) ...... 117
TABLE 93 GLOBAL COLORANTS EXCIPIENT MARKET VOLUME BY
TYPE, THROUGH 2016 (MILLION LBS) ..... 117
OTHER FUNCTIONAL USES . 117
MARKET SIZE . 118
TABLE 94 GLOBAL MARKET FOR OTHER FUNCTIONAL USES,
THROUGH 2016 ($ MILLIONS/MILLION LBS) ...... 118
PERFUMES ...... 118
BINDERS ... 118
BUFFERS .. 119
CHELATING AGENTS .. 119
COMPRESSION AIDS ... 119
EMULSIFIERS 119
FOAM CONTROL AGENTS . 120
GLIDANTS 120
HUMECTANTS 120
LUBRICANTS .. 120
PLASTICIZERS 121
PRESERVATIVES .. 121
THICKENERS .. 121
DELIVERY SYSTEMS ... 122
MARKET SIZE . 122
TABLE 95 VALUE OF THE GLOBAL EXCIPIENT DELIVERY
SYSTEMS MARKET BY TYPE, THROUGH 2016 ($ MILLIONS) ...... 122
TABLE 96 VOLUME OF THE GLOBAL EXCIPIENT DELIVERY
SYSTEMS MARKET BY TYPE, THROUGH 2016 (MILLION LBS) .... 123
FIGURE 8 GLOBAL EXCIPIENT DELIVERY SYSTEMS MARKET BY
TYPE, 2011 AND 2016 (%) . 123
FIGURE 8 (CONTINUED) ...... 124
INJECTIONS 124
TABLE 97 TYPICAL INJECTION COMPOSITION (%) 124
MARKET SIZE . 125
TABLE 98 GLOBAL EXCIPIENTS FOR INJECTIONS, MARKET
VALUE BY FUNCTION, THROUGH 2016 ($ MILLIONS) ..... 125
TABLE 99 GLOBAL EXCIPIENTS FOR INJECTIONS, MARKET
VOLUME BY FUNCTION, THROUGH 2016 (MILLION LBS) ..... 125
ORAL DELIVERY SYSTEMS .. 126
MARKET SIZE . 126
TABLE 100 VALUE OF THE GLOBAL EXCIPIENTS IN ORAL
DELIVERY SYSTEMS MARKET BY TYPE, THROUGH 2016 ($
MILLIONS) .... 127
TABLE 101 VOLUME OF THE GLOBAL EXCIPIENTS IN ORAL
DELIVERY SYSTEMS MARKET BY TYPE, THROUGH 2016
(MILLION LBS) .... 127
SOLIDS .. 127
MARKET SIZE . 127
TABLE 102 VALUE OF THE MARKET FOR GLOBAL EXCIPIENTS IN
ORAL SOLID DELIVERY SYSTEMS, BY TYPE, THROUGH 2016 ($
MILLIONS) .... 128
TABLE 103 VOLUME OF THE MARKET FOR GLOBAL EXCIPIENTS
IN ORAL SOLID DELIVERY SYSTEMS, BY TYPE, THROUGH 2016
(MILLION LBS) .... 128
TABLETS ...... 128
TABLE 104 TYPICAL TABLET COMPOSITION (WT/WT%) ..... 129
MARKET SIZE . 130
TABLE 105 VALUE OF THE GLOBAL EXCIPIENTS IN TABLETS
MARKET BY FUNCTION, THROUGH 2016 ($ MILLIONS) . 130
TABLE 106 VOLUME OF THE GLOBAL EXCIPIENTS IN TABLETS
MARKET BY FUNCTION, THROUGH 2016 (MILLION LBS) ...... 131
Market Size (Continued) ... 132
CAPSULES ... 133
MARKET SIZE . 133
TABLE 107 VALUE OF THE GLOBAL EXCIPIENTS IN GELATIN
CAPSULES MARKET BY TYPE, THROUGH 2016 ($ MILLIONS) .... 133
TABLE 108 VOLUME OF THE GLOBAL EXCIPIENTS IN GELATIN
CAPSULES MARKET BY TYPE, THROUGH 2016 (MILLION LBS) . 134
HARD GELATIN CAPSULES ..... 134
TABLE 109 TYPICAL HARD GELATIN CAPSULE COMPOSITION
(WT/WT%) ..... 134
Market Size ... 135
TABLE 110 GLOBAL EXCIPIENTS IN HARD GELATIN CAPSULES
MARKET VALUE BY FUNCTION, THROUGH 2016 ($ MILLIONS) .. 135
TABLE 111 GLOBAL EXCIPIENTS IN HARD GELATIN CAPSULES
MARKET VOLUME BY FUNCTION, THROUGH 2016 (MILLION
LBS) .. 135
SOFT GELATIN CAPSULES ...... 136
TABLE 112 TYPICAL SOFT GELATIN CAPSULE COMPOSITION 136
Market Size ... 136
TABLE 113 VALUE OF THE GLOBAL EXCIPIENTS IN SOFT
GELATIN CAPSULES MARKET, BY FUNCTION, THROUGH 2016 ($
MILLIONS) .... 137
TABLE 114 VOLUME OF THE GLOBAL EXCIPIENTS IN SOFT
GELATIN CAPSULES MARKET, BY FUNCTION, THROUGH 2016
(MILLION LBS) .... 137
LIQUIDS 138
TABLE 115 TYPICAL LIQUID COMPOSITION (%) ...... 138
MARKET SIZE . 138
TABLE 116 GLOBAL EXCIPIENTS IN LIQUIDS MARKET VALUE BY
FUNCTION, THROUGH 2016 ($ MILLIONS) .... 139
TABLE 117 GLOBAL EXCIPIENTS IN LIQUIDS MARKET VOLUME
BY FUNCTION, THROUGH 2016 (MILLION LBS) .. 139
TOPICAL DELIVERY SYSTEMS ... 140
MARKET SIZE . 140
TABLE 118 VALUE OF GLOBAL EXCIPIENTS IN TOPICAL
DELIVERY SYSTEMS BY TYPE, THROUGH 2016 ($ MILLIONS) ... 141
TABLE 119 VOLUME OF GLOBAL EXCIPIENTS IN TOPICAL
DELIVERY SYSTEMS BY TYPE, THROUGH 2016 (MILLION LBS) 141
TABLE 120 TYPICAL OINTMENT COMPOSITION (%) ...... 142
CREAMS AND GELS .... 142
TABLE 121 TYPICAL CREAM COMPOSITION (%) ...... 142
LOTIONS ... 143
TABLE 122 TYPICAL TOPICAL LOTION COMPOSITION (%) . 143
DERMAL POWDERS ..... 144
SOLUTIONS ..... 144
ADVANCED DELIVERY SYSTEMS ..... 144
MARKET SIZE . 145
TABLE 123 GLOBAL EXCIPIENT ADVANCED DELIVERY SYSTEMS
VALUE BY FUNCTION, THROUGH 2016 ($ MILLIONS) ..... 145
TABLE 124 GLOBAL EXCIPIENT ADVANCED DELIVERY SYSTEMS
VOLUME BY FUNCTION, THROUGH 2016 (MILLION LBS) ...... 146
CYCLODEXTRINS . 146
HYDROGELS ... 146
IMPLANTS 146
LIPOSOMES .... 147
MICROPARTICLES 147
MICROSPHERES ... 147
NANOTECHNOLOGY (NANOPARTICLES) .. 147
Nanotechnology (nanoparticles) (Continued) ...... 148
OSMOTIC PUMPS .. 149
TRANSDERMAL ..... 150
TRANSMUCOSAL .. 150
Buccal ..... 150
Tablets 151
Capsules .... 152
Lozenges .... 152
Particles ..... 152
Thin Strips 153
Inhalation ...... 153
Nasal ... 154
Pulmonary . 154
Ophthalmic ... 155
Otic .. 155
Rectal ..... 156
Vaginal ... 156
FINISHED PRODUCTS .... 157
MARKET SIZE . 157
TABLE 125 VALUE OF THE GLOBAL EXCIPIENTS MARKET IN
FINISHED PRODUCTS BY TYPE, THROUGH 2016 ($ MILLIONS) . 158
TABLE 126 VALUE OF THE GLOBAL EXCIPIENTS MARKET IN
FINISHED PRODUCTS BY TYPE, THROUGH 2016 (MILLION LBS) ..... 158
PRESCRIPTION PRODUCTS . 159
MARKET SIZE . 159
TABLE 127 VALUE OF THE GLOBAL EXCIPIENTS IN
PRESCRIPTION DRUGS MARKET, BY DELIVERY SYSTEM,
THROUGH 2016 ($ MILLIONS) ...... 159
TABLE 128 VOLUME OF THE GLOBAL EXCIPIENTS IN
PRESCRIPTION DRUGS MARKET, BY DELIVERY SYSTEM,
THROUGH 2016 (MILLION LBS) ... 160
INJECTIONS ... 160
Market Size ... 160
TABLE 129 VALUE OF GLOBAL EXCIPIENTS IN INJECTED
PRESCRIPTION DRUGS BY TYPE, THROUGH 2016 ($ MILLIONS) 161
TABLE 130 VOLUME OF GLOBAL EXCIPIENTS IN INJECTED
PRESCRIPTION DRUGS BY TYPE, THROUGH 2016 (MILLION
LBS) .. 161
Small Molecule Drug Injections ...... 161
TABLE 131 GLOBAL EXCIPIENTS IN INJECTED PRESCRIPTION
SMALL MOLECULE DRUGS MARKET, THROUGH 2016 ($
MILLIONS/MILLION LBS) ..... 162
Biologic Drug Injections .... 162
TABLE 132 GLOBAL EXCIPIENTS IN INJECTED RX BIOLOGIC
DRUGS MARKET, THROUGH 2016 ($ MILLIONS/MILLION LBS) .. 162
Protein Drugs ... 163
Vaccines ..... 164
ORAL PRESCRIPTION DRUGS . 164
Market Size ... 164
TABLE 133 GLOBAL EXCIPIENTS IN ORAL RX DRUGS MARKET,
THROUGH 2016 ($ MILLIONS/MILLION LBS) ...... 165
TOPICAL ... 165
TABLE 134 GLOBAL EXCIPIENTS IN TOPICAL RX DRUGS MARKET,
THROUGH 2016 ($ MILLIONS/MILLION LBS) ...... 166
ADVANCED DRUG DELIVERY SYSTEMS ... 166
TABLE 135 GLOBAL EXCIPIENTS IN ADVANCED SYSTEMS FOR
PRESCRIPTION DRUGS MARKET, THROUGH 2016 ($
MILLIONS/MILLION LBS) ..... 166
OVER-THE-COUNTER PRODUCTS .... 166
MARKET SIZE . 167
TABLE 136 VALUE OF THE GLOBAL EXCIPIENTS IN OTC FINISHED
PRODUCTS MARKET, BY DELIVERY SYSTEM, THROUGH 2016 ($
MILLIONS) .... 167
TABLE 137 VOLUME OF GLOBAL EXCIPIENTS IN OTC FINISHED
PRODUCTS MARKET, BY DELIVERY SYSTEM, THROUGH 2016
(MILLION LBS) .... 168
FINISHED PRODUCT TRENDS .... 168
PHARMACOGENOMICS ..... 168
COUNTERFEIT/STOLEN DRUGS .... 169
INDUSTRY STRUCTURE .... 169
INDUSTRY ENVIRONMENT .. 170
MARKET INFLUENCES ..... 170
Pharmaceutical Industry Pressures ...... 170
General Health Trends ...... 170
Healthcare Industry ...... 171
Consumer Demographics .. 171
IMPORTANT STRATEGIES .... 172
R&D SPENDING .... 172
CONSUMER ADVERTISING ..... 172
LEGISLATIVE LOBBYING . 172
CONSOLIDATION .. 172
MULTIPLICITY OF DELIVERY SYSTEMS ... 173
SUPPLIER LISTS ... 173
MATERIAL CHOICE DECISIONS .... 173
DRIVING FORCES ..... 174
MARKET SHARES ..... 174
FIGURE 9 SIMPLIFIED INDUSTRY STRUCTURE ..... 174
RAW MATERIAL SUPPLIERS ... 175
Organic Chemical Suppliers .... 175
Carbohydrate Suppliers . 175
Cellulose Suppliers . 175
FIGURE 10 MARKET SHARE OF MAJOR CELLULOSE SUPPLIERS,
2011 (%) ... 176
Sugar Suppliers 176
Actual Sugar Suppliers .. 176
FIGURE 11 MARKET SHARE OF ACTUAL SUGAR EXCIPIENT
SUPPLIERS, 2011 (%) . 177
Sugar Alcohols (Polyols) 178
FIGURE 12 ESTIMATED MARKET SHARE OF MAJOR SUGAR
ALCOHOL (POLYOL) EXCIPIENT SUPPLIERS, 2011 (%) .... 178
Artificial Sweeteners...... 179
Starch Suppliers ...... 179
FIGURE 13 ESTIMATED MARKET SHARE OF MAJOR STARCH
EXCIPIENT SUPPLIERS, 2011 (%) 180
Protein Suppliers .... 180
FIGURE 14 ESTIMATED MARKET SHARE OF MAJOR PROTEIN
(GELATIN) EXCIPIENT SUPPLIERS, 2011 (%) 181
Petrochemical Suppliers 182
Glycol Suppliers ...... 182
FIGURE 15 ESTIMATED MARKET SHARE OF MAJOR GLYCOL
EXCIPIENT SUPPLIERS, 2011 (%) 182
PVP Suppliers .. 183
Mineral Hydrocarbon Suppliers . 183
Acrylic Suppliers ..... 183
Oleochemical Suppliers . 183
FIGURE 16 ESTIMATED MARKET SHARE OF MAJOR
OLEOCHEMICAL EXCIPIENT SUPPLIERS, 2011 (%) .. 184
Inorganic Chemical Suppliers .. 185
Calcium Salts Suppliers 185
FIGURE 17 ESTIMATED MARKET SHARE OF MAJOR CALCIUMBASED
EXCIPIENTS SUPPLIERS, 2011 (%) .... 185
Halite Suppliers ...... 186
FIGURE 18 ESTIMATED MARKET SHARE OF MAJOR HALITE
EXCIPIENT SUPPLIERS, 2011 (%) 186
FIGURE 18 (CONTINUED) .... 187
Metal Oxide Suppliers ... 187
FIGURE 19 ESTIMATED MARKET SHARE OF MAJOR METAL
OXIDES EXCIPIENT SUPPLIERS, 2011 (%) .... 188
Silicate Suppliers .... 189
USP Water Suppliers . 189
FIGURE 20 ESTIMATED MARKET SHARE OF MAJOR USP WATER
SUPPLIERS, 2011 (%) . 189
DISTRIBUTORS/MODIFIERS .... 190
Distributors ... 190
TABLE 138 DISTRIBUTOR CATEGORIES ..... 191
Brokers ...... 191
Import/Export Traders .. 191
Chemical Stocking/Repacking ..... 191
Modifiers 192
TABLE 139 CATEGORIES OF MODIFIERS .... 192
Contract Development Organizations 192
Contract Coaters ..... 193
END USERS ..... 193
TABLE 140 CATEGORIES OF MODIFIERS .... 193
Drug Companies .. 193
Contract Formulators . 194
Retail and Hospital Pharmacies ..... 194
Pharmacy Colleges and Other Academic Institutions ...... 195
Other End Users .. 195
INTERNATIONAL ASPECTS ..... 195
Americas 195
Europe .... 196
Asia/Pacific Rim ... 196
Others ..... 197
CHAPTER SIX: COMPANY PROFILES .. 198
COMPANY PROFILES ..... 198
COMPANY PROFILES (CONTINUED) ... 199
ABBOTT LABORATORIES ...... 200
ADAMAS PHARMACEUTICALS, INC. 201
ADM (ARCHER DANIELS MIDLAND CO.) 201
AKZO NOBEL N.V. (ALSO ICI AND NATIONAL STARCH) . 201
AMERICHEM PHARMACEUTICAL CORP. ...... 202
AMTEX (QUIMICA AMTEX MEXICO) . 203
ARLA FOODS A.M.B.A. .... 203
ASAHI KASEI CORP. (ASAHI KASEI PHARMA) .... 204
ASHLAND AQUALON FUNCTIONAL INGREDIENTS (AAFI) ... 205
ASSOCIATED BRITISH FOODS (ABF) 206
BANNER PHARMACAPS, INC. ..... 206
BASF A.G. ..... 207
BASF A.G. (CONTINUED) ... 208
BAXTER INTERNATIONAL, INC. 209
BLANVER FARMOQUIMICA, LTDA. .. 210
BLUE REFERENCE ... 210
BRENNTAG GROUP .. 211
BUDENHEIM ...... 211
CABOT CORP. ..... 212
CALUMET SPECIALTY PRODUCTS PARTNERS, LP (PENRECO) .. 212
CARGILL, INC. .... 213
CHARLES TENNANT & CO., LTD. ...... 214
CHR. HANSEN A/S .... 214
COGNIS DEUTSCHLAND GMBH & CO. K.G. .. 215
COLORCON, INC. ...... 216
CORN PRODUCTS INTERNATIONAL, INC. .... 217
COSMETIC SPECIALTIES, INC. ... 218
CRISTAL GLOBAL (NATIONAL TITANIUM DIOXIDE CO., LTD.) ... 218
CRODA INTERNATIONAL, PLC ... 219
CSL BEHRING, LLC .. 220
CSM N.V. 220
CTD, INC. ...... 221
CYDEX PHARMACEUTICALS, INC. ... 221
DANISCO A/S ...... 222
DOW CHEMICAL CO. ...... 223
DOW CHEMICAL CO. (CONTINUED) .... 224
DUPONT (E.I. DU PONT DE NEMOURS & CO.) ..... 225
EASTMAN CHEMICAL CO. .... 226
EM2 SOLUTIONS, INC. ... 227
EURAND 227
EVONIK DEGUSSA GMBH (EVONIK INDUSTRIES AG) .... 227
FERRO CORP. ..... 228
FIBROGEN, INC. 229
FINNBRIT CONSULTING ...... 229
FLAVORX INC. .... 229
FMC CORP. ... 230
FMC CORP. (CONTINUED) 231
FMC CORP. (CONTINUED) 232
FONTERRA CO-OPERATIVE GROUP, LTD. .... 233
FOREMOST FARMS USA 233
FUJI HEALTH SCIENCE, INC. (FUJI CHEMICAL INDUSTRY CO.,
LTD.) . 234
GATTEFOSSE GROUP ..... 234
GE HEALTHCARE ..... 235
GELITA AG ... 235
GENERAL CHEMICAL (GENCHEM) .. 236
GLATT GMBH (GLATT AIR TECHNIQUES, INC.) . 236
GRAIN PROCESSING CORP. . 237
GRIFOLS S.A. (LABORATORIOS GRIFOLS S.A.)... 237
GTC BIOTHERAPEUTICS, INC. ... 238
HILMAR CHEESE CO. (HILMAR INGREDIENTS) . 238
HOLLANDSE MELKSUIKERFABRIEK ..... 239
IMERYS .. 239
INNOPHOS, INC. 240
INTERNATIONAL SPECIALTY PRODUCTS (ISP) . 240
INTERNATIONAL SPECIALTY PRODUCTS ...(CONTINUED) ..... 241
J.M. HUBER CORP. (CP KELCO AND HUBER ENGINEERED
MATERIALS) .. 242
CP KELCO . 242
HUBER ENGINEERED MATERIALS ..... 242
JOST CHEMICAL CO. ...... 243
JRS PHARMA (AND J. RETTENMAIER).... 243
KEMIRA OYJ 244
KOSTER KEUNEN HOLLAND B.V. .... 245
KRAFT FOODS ATLANTIC GELATIN 245
KRONOS WORLDWIDE, INC. 245
LANXESS A.G. ..... 246
LUBRIZOL CORP. ...... 246
LYONDELLBASELL INDUSTRIES ..... 247
MALLINCKRODT BAKER, INC. (COVIDIEN) .. 247
MEGGLE GMBH . 248
MERCK KGAA (AND EMD) .... 249
MICRO-MACINAZIONE S.A. .. 250
MINERALS TECHNOLOGIES, INC. (SPECIALTY MINERALS, INC.) .... 250
MINGTAI CHEMICAL CO., LTD. .. 251
MITSUBISHI CHEMICAL PERFORMANCE POLYMERS, INC. . 252
MUTCHLER, INC. PHARMACEUTICAL INGREDIENTS .... 252
NITTA GELATIN, INC. ..... 252
NORDZUCKER AG .... 253
NOVOZYMES A/S 253
NUSIL TECHNOLOGY ..... 254
NUTRASWEET CO. ... 254
OMYA A.G. .... 255
PARAYTEC, LTD. 256
PERRIGO CO. ...... 256
PFIZER, INC. 256
P&G CHEMICALS ...... 257
PHARMACEUTICAL-TECHNOLOGY.COM ...... 257
PMC GLOBAL, INC. ... 258
PURDUE PHARMA, LP .... 258
QUALITY SYSTEMS DESIGN, INC. .... 259
RHODIA S.A. 259
RIO TINTO, PLC . 259
ROQUETTE FRERES 260
ROUSSELOT S.A.S. ... 261
ROYAL FRIESLANDCAMPINA N.V. ... 262
R.T. VANDERBILT COMPANY, INC. ... 263
SASOL, LTD. ADR ...... 263
SENSIENT TECHNOLOGIES CORP. .. 264
SEPPIC S.A. .. 264
SHEFFIELD PHARMA INGREDIENTS...... 265
SHELL CHEMICALS (ROYAL DUTCH SHELL) ...... 266
SHIN-ETSU CHEMICAL CO., LTD. ..... 266
SOLVAY S.A. 267
SPI PHARMA, INC. .... 268
STEPAN CO. . 268
STERLING BIOTECH, LTD. ... 269
TAKEHARA CHEMICAL INDUSTRIAL CO., LTD. . 269
TALECRIS BIOTHERAPEUTICS, INC. ...... 270
TATE & LYLE, PLC ... 270
TESSENDERLO GROUP (PB GELATINS) . 271
TOMITA PHARMACEUTICAL CO., LTD. ... 272
UNIVAR N.V. (AND UNIVAR USA)...... 272
USG CORP. ... 272
VALIDATION & ENGINEERING GROUP (VEG) .... 273
VERTELLUS PERFORMANCE MATERIALS, INC. (VPMI) 273
WACKER FINE CHEMICALS (WACKER CHEMIE) ...... 273
WEI MING PHARMACEUTICAL MFG. CO., LTD. .. 274
WEISHARDT GROUP 275
W.R. GRACE & CO. .... 275
