Global Spinal Surgery Devices Market Outlook to 2015

1 Table of Contents 2
1.1 List of Tables 6
1.2 List of Figures 7
2 Definitions and Market Segmentation 9
2.1 Spinal Surgery 9
2.1.1 Spinal Fusion 9
2.1.2 Spinal Non-Fusion 9
3 Executive Summary 11
4 Spinal Surgery – Disease Background 12
4.1 Spine Structure 12
4.2 Key Spinal Disease Conditions 13
4.2.1 Vertebral Compression Fractures 13
4.2.2 Osteoporosis 13
4.2.3 Degenerative Disc Disease 13
4.2.4 Herniated Disc 14
4.2.5 Spondylolisthesis 15
5 Global Spinal Surgery Devices Market Outlook 16
5.1 Global Spinal Surgery Devices: Market Overview 16
5.2 Global Spinal Surgery Devices Market – Cross Segment Analysis 18
6 Category Analysis – Spinal Fusion 20
6.1 Spinal Fusion Market Outlook 20
6.2 Spinal Fusion Trend Analysis 21
6.2.1 Spinal Fusion Market Drivers 21
6.2.2 Spinal Fusion Market Restraints 21
6.3 Pedicle Screws 22
6.3.1 Pedicle Screws Market Size, Historic, 2001 – 2008 22
6.3.2 Pedicle Screws Market Size, Forecast, 2008 – 2015 23
6.3.3 Key Pipeline Products 24
6.4 Interbody Cages 25
6.4.1 Interbody Cages Market Size, Historic, 2001 – 2008 25
6.4.2 Interbody Cages Market Size, Historic, 2008 – 2015 26
6.4.3 Key Pipeline Products 27
7 Category Analysis – Spinal Non-Fusion 28
7.1 Spinal Non-Fusion Market Outlook 28
7.2 Spinal Non-Fusion: Trend Analysis 29
7.2.1 Spinal Non-Fusion Market Drivers 29
7.2.2 Spinal Non-Fusion Market Restraints 29
7.3 Dynamic Stabilization 30
7.3.1 Dynamic Stabilization Market Size, Historic, 2001 – 2008 31
7.3.2 Dynamic Stabilization Market Size, Historic, 2008 – 2015 32
7.3.3 Key Pipeline Products 33
7.4 Artificial Disc Replacement 34
7.4.1 Artificial Disc Replacement Market Size, Historic, 2001 – 2008 34
7.4.2 Artificial Disc Replacement Market Size, Forecast, 2008 – 2015 35
7.4.3 Key Products 36
7.4.4 Key Pipeline Products 38
8 Spinal Surgery Market – Pipeline Portfolio Analysis 39
8.1 Key Spinal Surgery Pipeline Devices 41
8.1.1 Prestige LP 41
8.1.2 Flexicore Lumbar Artificial Disc 42
8.1.3 Anatomic Facet Replacement System (AFRS) 43
8.1.4 Percutaneous Disc Nucleus 44
8.1.5 Neodisc 45
8.1.6 Wallis System 46
8.1.7 Kineflex Lumbar Disc 47
9 Spinal Surgery Market – Technology Insight 48
9.1 Nucleus Replacement - Next Big Opportunity in the Spinal Surgery Market 48
9.1.1 Background 48
9.1.2 Types of Nucleus Implants 48
9.1.3 Nucleus Replacement – Key Benefits Over The Existing Technologies 48
9.1.4 Future Outlook 49
10 Spinal Surgery Market – Trend Assessment 50
10.1 Rising Spinal Disease Incidence 50
10.2 Reimbursement 51
10.3 Start Up Companies with Devices of the Future 51
10.3.1 Nuvasive 51
10.3.2 Disc Dynamics 52
10.3.3 Spine Wave, Inc. 52
10.4 Regulatory environment 53
10.4.1 Ruling To Provide Immunity for Medical Equipment Manufacturers and the Medical Device Safety Act of 2008 53
10.4.2 FDA in Favor of Off-Label Marketing 54
10.5 Device Recalls and Safety Concerns 55
11 Spinal Surgery Devices: M&A Landscape 56
11.1 Past, Present and Future 56
11.2 Key M&A Events 57
11.2.1 Zimmer Holdings to acquire Abbott Spine 57
11.2.2 Integra LifeSciences acquires Theken Group of Companies 58
11.2.3 Medtronic acquires Kyphon 60
12 Spinal Surgery Devices: Company Performance Analysis 61
12.1 Medtronic, Inc. 63
12.1.1 Key Highlights 63
12.1.2 Financial Overview 63
12.1.3 SWOT Analysis 65
12.1.4 M&A Analysis 70
12.1.5 Pipeline Analysis 71
12.2 DePuy, Inc. 72
12.2.1 Financial Overview 72
12.2.2 Key Highlights 73
12.2.3 M&A Analysis 74
12.2.4 Pipeline Analysis 75
12.3 Synthes GmbH 76
12.3.1 Financial Overview 76
12.3.2 SWOT Analysis 76
12.3.3 M&A Analysis 80
12.3.4 Pipeline Analysis 80
12.4 Stryker Corporation 81
12.4.1 Financial Overview 81
12.4.2 SWOT Analysis 82
12.4.3 M&A Analysis 86
12.4.4 Pipeline Analysis 86
12.5 Zimmer Holdings, Inc. 87
12.5.1 Financial Overview 87
12.5.2 SWOT Analysis 88
12.5.3 M&A Analysis 93
12.5.4 Pipeline Analysis 94
13 Spinal Surgery Market: Future Outlook 95
14 Appendix 96
14.1 Conferences 96
14.2 Cross Segment Analysis 96
14.3 Methodology 96
14.3.1 Coverage 97
14.3.2 Secondary Research 98
14.3.3 Primary Research 98
14.3.4 Models 99
14.3.5 Forecasts 99
14.3.6 Expert Panels 99
14.4 Contact Us 100
14.5 Disclaimer 100

1.1 List of Tables
Table 1: Spinal Surgery Market, Global, Revenue ($ m), 2001-2015 17
Table 2: Spinal Surgery Market, Cross Segment Analysis, 2008 18
Table 3: Spinal Fusion, Global, Revenue by Segment ($ m), 2001-2015 21
Table 4: Pedicle Screws, Global, Revenue ($ m), 2001-2008 22
Table 5: Pedicle Screws, Global, Revenue ($ m), 2008-2015 23
Table 6: Pedicle Screw Systems, Pipeline Products, 2008 24
Table 7: Interbody Cages, Global, Revenue ($ m), 2001-2008 25
Table 8: Interbody Cages, Global, Revenue ($ m), 2008-2015 26
Table 9: Interbody Cages, Pipeline Products, 2008 27
Table 10: Spinal Non-Fusion, Global, Revenue by Segment ($ m), 2001-2015 29
Table 11: Dynamic Stabilization, Global, Revenue ($ m), 2001-2008 31
Table 12: Dynamic Stabilization, Global, Revenue ($ m), 2008-2015 32
Table 13: Dynamic Stabilization, Pipeline Products, 2008 33
Table 14: Artificial Disc Replacement Market, Global, Revenue ($m), 2001 – 2008 34
Table 15: Artificial Disc Replacement Market, Global, Revenue ($m), 2008 – 2015 35
Table 16: Artificial Disc Replacement, Key Pipeline Products, 2008 38
Table 17: Spinal Surgery Market, Pipeline Products by Category and Geography, 2008 39
Table 18: Spinal Surgery Market, Pipeline Products by Category and Development Stage, 2008 40
Table 19: Prestige LP Product Details 41
Table 20: Flexicore Lumbar Artificial Disc Product Details 42
Table 21: Anatomic Facet Replacement System (AFRS) Product Details 43
Table 22: Percutaneous Disc Nucleus Product Details 44
Table 23: Neodisc Product Details 45
Table 24: Wallis System Product Details 46
Table 25: Kineflex Lumbar Disc Product Details 47
Table 26: Key Pipeline Products in the Global Nucleus Replacement Market, 2008 49
Table 27: Physician Visits For Back Disorders, United States, 2005 50
Table 28: Intervetebral Disc Excision Procedure by Age Group, 2005 51
Table 29: Spinal Surgery, Global, Company Share (%), 2007 62
Table 30: Medtronic, Inc., Company Revenues ($ m), 2004 – 2008 64
Table 31: DePuy, Inc., Spinal Surgery Revenues ($ m), 2005 – 2007 73
Table 32: Stryker Corporation, Company Revenues ($ m), 2003 – 2007 82
Table 33: Zimmer Holdings, Inc., Company Revenues ($ m), 2003 – 2007 87
Table 34: List of Key Spine Conferences in 2009 96

1.2 List of Figures
Figure 1: Spinal Surgery Market Segmentation 10
Figure 2: Structure of the Spine 12
Figure 3: Difference Between a Normal and an Osteoporotic Bone 13
Figure 4: Herniated Disc Incidence, Split by Location 14
Figure 5: Spondylolisthesis Incidence, Split by Location 15
Figure 6: Spinal Surgery Market, Global, Revenue ($ m), 2001-2015 16
Figure 7: Spinal Surgery Market, Cross Segment Analysis, 2008 18
Figure 8: Spinal Fusion, Global, Revenue by Segment ($ m), 2001-2015 20
Figure 9: Pedicle Screws, Global, Revenue ($ m), 2001-2008 22
Figure 10: Pedicle Screws, Global, Revenue ($ m), 2008-2015 23
Figure 11: Interbody Cages, Global, Revenue ($ m), 2001-2008 25
Figure 12: Interbody Cages, Global, Revenue ($ m), 2008-2015 26
Figure 13: Spinal Non-Fusion, Global, Revenue by Segment ($ m), 2001-2015 28
Figure 14: Spine Movement With Dynamic Stabilization Devices 30
Figure 15: Dynamic Stabilization, Global, Revenue ($ m), 2001-2008 31
Figure 16: Dynamic Stabilization, Global, Revenue ($ m), 2008-2015 32
Figure 17: Artificial Disc Replacement Market, Global, Revenue ($m), 2001 – 2008 34
Figure 18: Artificial Disc Replacement Market, Global, Revenue ($m), 2008 – 2015 35
Figure 19: Charité Structure 36
Figure 20: ProDisc Structure 36
Figure 21: Prestige Structure 37
Figure 22: Spinal Surgery Market, Pipeline Products by Category and Geography, 2008 39
Figure 23: Spinal Surgery Market, Pipeline Products by Category and Development Stage, 2008 40
Figure 24: Spinal Surgery Market, Product Recalls by Company, January 2008-October 2008 55
Figure 25: Spinal Surgery Market, Deal by Type, 2003 – 2008 56
Figure 26: Spinal Surgery Market, Deal by Year, 2003 – 2008 57
Figure 27: Zimmer’s Acquisition of Abbott Spine, Key Facts, 2008 58
Figure 28: Integra’s Acquisition of Theken, Key Facts, 2008 59
Figure 29: Medtronic’s Acquisition of Kyphon, Key Facts, 2007 60
Figure 30: Spinal Surgery, Global, Company Share (%), 2007 61
Figure 31: Medtronic, Inc., Spinal Surgery Revenues ($ m), 2004 – 2008 64
Figure 32: Medtronic, Inc., SWOT Analysis 65
Figure 33: Medtronic, Inc., Merger and Acquisition Landscape, 2002 – 2007 70
Figure 34: Medtronic, Inc., Spinal Surgery Pipeline Analysis 71
Figure 35: DePuy, Inc., Spinal Surgery Revenues ($ m), 2005 – 2007 72
Figure 36: Medtronic, Inc., Merger and Acquisition Landscape, 2003 – 2007 74
Figure 37: DePuy, Inc., Spinal Surgery Pipeline Analysis 75
Figure 38: Synthes GmbH, SWOT Analysis 76
Figure 39: Synthes, Inc., Merger and Acquisition Landscape, 2003 – 2007 80
Figure 40: Synthes, Inc., Spinal Surgery Pipeline Analysis 80
Figure 41: Stryker Corporation, Company Revenues ($ m), 2003 – 2007 81
Figure 42: Stryker Corporation, SWOT Analysis 82
Figure 43: Stryker Corporation, Spinal Surgery Pipeline Analysis 86
Figure 44: Zimmer Holdings, Inc., SWOT Analysis 88
Figure 45: Zimmer Holdings, Inc., Spinal Surgery Pipeline Analysis 94
Figure 46: Global Markets Direct Methodology 97