Growth Factors (Blood And Tissue) - A World Report

1.METHODOLOGY
Study Reliability and Reporting Limitations
Disclaimers
Quantitative Techniques & Reporting Level
2.INTRODUCTION
Growth Factors: A Preface
Growth Factors: Their Role and Related Applications
Growth Factors: Adding a New Dimension
Growth Factors: Classification Based on Activity
Recent Trends & Developments
Recombinant Human Erythropoietin: Gradually Gaining Dominance
3.MARKET OVERVIEW
EPO – The Lead ‘Factor’
Leading EPO Drugs Worldwide
Market Comparison of Erythropoietin-Based Drugs in America and European Union: Classification Based on Key Parameters
Patent Expiries of Major Biopharmaceutical Drugs
4.MARKET DYNAMICS
Dethroning the Leaders
Expiration of Patents Fuels Competition and Sales
India – At the Center Stage…
Side Effects – Still a Concern…
CDER- A Regulatory Review Authority for Growth Factors
5.OUTLOOK
Innovative Delivery System Shows Potential for Accelerating Use of Growth Factors
Cytokines - Vital Growth Propellers for the Future of New Drugs
Brain Derived Neurotrophic Factor (BDNF) Finds Increased Application
Age-Related Diseases – Their Influence on Effective Therapies
Copaxone Finds Novel Applications
Mimetic Growth Factors – Exhibiting Promising Potential
6.INDUSTRY ISSUES
Development of Cost Effective Methods – Need of the Hour
Influence of Neurotrophic Factors on Brain Cell Development
Combination of Interferons and Ribavirin Develops More Anemia Cases
7.COMPETITIVE TRENDS
RegeneRx Focuses on Wound Healing Market
DRL Introduces a Program to Propel its Biogenerics Business
8.PRODUCT FACTS
Blood Growth Factors
Erythropoietins
Colony Stimulating Factors
Interferons
Types of Interferons
Interleukins
Types of Interleukins
Tissue Growth Factors
Tissue Growth Factors: Classification Based on Key Source and Principal Activity
Growth Factors: Application by Compound and Supplier
Growth Factors: Indicated Applications by Site/Course of Action
9.RESEARCH AND DEVELOPMENT HIGHLIGHTS
Maxygen Updates on Factor VII Program
Evaluation of Extended Dosing Schedule of PROCRIT®
PROCRIT® - A Better Option
Nerve Growth Factor Shows Promising Potential Against Diabetes
Cytokines and GM-CSF Found to be Closely Interlinked
GM-CSF Enhances Rate of Survival in Neonates
rG-CSF Well Tolerated in Pneumonia and Severe Sepsis Patients
rG-CSF- Their Influence on Preterm Infants with Sepsis
Serum Macrophage Colony Stimulating Growth Factors Associated with Thrombocyte and Monocyte
Src Pathway Inactivation in Kit Impairs Blood Cell Growth and Proliferation
Cole Eye Institute Offers TIMP-3 Mechanism for Preventing Abnormal Growth of Blood Vessels
Effect of Brain Derived Neurotrophic Factor on Retinal Cells
Orcel™ Exhibits High Growth Factor for Wound Healing and Cardiovascular Applications
Drug Combination of Macrophage Colony Stimulating Factor Shows Successful Tolerance Levels
Neotrofin™ Triggers Neurotrophic Factors
G-CSF Shows Capability for Promoting Neutrophil Production
Insulin-like Growth Factor-1 (IGF) Gene Transfer Accelerates Wound Healing Process
Hepatocyte Growth Factors – Exhibiting Dual Role
Cortex Pharmaceuticals Ampakines® Promotes Expression of Neurotrophin
Granulocyte Colony Stimulating Factor Finds Application in Treating Neonates
Cerebrolysin Promotes Cognition
10.BREAKTHROUGHS – A REVIEW
Novel Set of Human Cytokines Unveiled
IGFBP-3 and its Potential to Ward Off Gastric Cancer
Bone Morphogenic Proteins Show Potential for Musculoskeletal Regeneration
Growth Factors – Their Role in Preventing Heart Stroke
Growth Factor Proteins Shows Promising Results for Treating Cancer
Neurotrophic Growth Factor Primarily Responsible for Loss of Vision
Redox-Active Grape Seed Exhibits Favorable Properties for Dermal Wound Healing
Role of Brain-Derived Neurotrophic Factor on Memory
Nerve Growth Factor Found to Enhance Barium Current and Insulin Secretion
Lipid Peroxidation May be Associated with Wound Healing
Genentech Inc Unveils Molecule for Stimulating Growth of Blood Vessels
Connective Tissue Growth Factor Found to Promote Lung Fibroblast
Influence of Insulin-Like Growth Factor on Growth
Regeneron Discovers Angiopoietins Targeted at Blood Vessel Growth and Repair
Environment and Insulin-Like Growth Factors Stimulate Risk of Cancer
Cocktail of Neurotrophic Factors Promotes Regeneration of Torn Nerves
Growth Factors Administration to Stimulate Tissue Repair
Cytokine – Their Role in Combating Hepatitis C Virus
Axokine® Yields Favorable Results Against Obesity
Cell Genesys Unveils GDNF Gene Therapy Targeted Against Parkinson’s Disease
11.CORPORATE DEVELOPMENTS
Pfizer Inks Exclusive Global Licensing Agreement with Scil Technology
ZGEN Initiates Ph II Trial of Interleukin 21
FzioMed Bags Health Canada Approval on Oxiplex®
NsGene A/S Implants Encapsulated Cell in Patients
Reliance Life Sciences Takes Over Genemedix
Fraunhofer Institute Introduces First Interferon Beta 1a to Treat Multiple Sclerosis
Shanghai Wanxing Inks Export Deal for Recombinant Human Interferon
Hemispherx Enters into Distribution Agreement with Armada
Bayer Launches US Pharmaceuticals Subsidiary
Merck Inks Agreement with Bristol-Myers Squibb and ImClone
CoGenesys Signs Global Licensing Agreement with Vegenics
InterMune Inks New Supply Deal with Boehringer Ingelheim
Boston Life Sciences Adopts New Name of Alseres Pharmaceuticals
Cambrex Divests Bioproducts and Biopharma Subsidiaries
Dragon Divests EPO Business
Caregene and Genzyme Forms Partnership to Develop Cere-120
Amgen Bags EC Approval on Use of Aranesp(R) in Paediatric Patients
NsGene to Undertake Phase Ib Clinical Trial of NsG0202
Roche Receives European Approval for NeoRecormon
Bolder Receives Two U.S. Patents for Hematopoietic Factors
Hospira Receives EC Approval on Retacrit
RLS to Initiate Clinical Trials of Erythropoietin
InterMune Drops Phase III trial of Interferon
Chugai to Conduct Additional Trial on Epogin®
12.MAJOR PLAYERS
Amgen, Inc. (USA)
BioMimetic Therapeutics, Inc. (USA)
Biopharm GmbH (Germany)
Bolder Biotechnology, Inc. (USA)
Alseres Pharmaceuticals, Inc. (USA)
Ceregene, Inc. (USA)
FibroGen, Inc. (USA)
FzioMed, Inc. (USA)
Insmed, Inc. (USA)
Johnson & Johnson (USA)
Janssen-Ortho, Inc. (Canada)
Lonza Group (Switzerland)
Maxygen, Inc. (USA)
Merck Serono International S.A. (Switzerland)
NsGene A/S (Denmark)
PeproTech, Inc. (USA)
Rentschler Biotechnologie GmbH (Germany)
F. Hoffmann-La Roche Ltd (Switzerland)
Chugai Pharmaceutical Co. Ltd. (Japan)
Genentech, Inc. (USA)
Shantha Biotechnics (India)
Scil Proteins GmbH (Germany)
Wockhardt Ltd. (India)
13.MARKET ANALYTICS
14.THE UNITED STATES
EPO Market Scenario
Key Market Driver for EPO
Leading EPO Drugs in the US
15.JAPAN
Erythropoietin Market: Competitive Scenario
Leading EPO Drugs in Japan
Market Scenario for Biotech Products
Biotech Market Backed by Public Assistance
16.EUROPE
17.REST OF WORLD
An Overview of Indian Market
Erythropoietin
G-CSF Market
Interferon59Table 1: Global Growth Factors (Blood and Tissue) Market by Region for the Period 2007-2015 (Sales in US$ Million)
Table 2: Percentage Breakdown of Global Growth Factors (Blood and Tissue) Market by Region for the Years 2008 & 2009
Table 3: Global Blood Growth Factors Market by Region for the Period 2007-2015 (Sales in US$ Million)
Table 4: Percentage Breakdown of Global Blood Growth Factors Market by Region for the Years 2008 & 2009
Table 5: Global Blood Growth Factors Market by Type for the Period 2007-2015 (Sales in US$ Million)
Table 6: Percentage Breakdown of Global Blood Growth Factors Market by Type for the Years 2008 & 2009
Table 7: Global Erythropoietins Market by Region for the Period 2007-2015 (Sales in US$ Million)
Table 8: Percentage Breakdown of Global Erythropoietins Market by Region for the Years 2008 & 2009
Table 9: Global Colony Stimulating Factors Market by Region for the Period 2007-2015 (Sales in US$ Million)
Table 10: Percentage Breakdown of Global Colony Stimulating Factors Market by Region for the Years 2008 & 2009
Table 11: Global Interferons Market by Region for the Period 2007-2015 (Sales in US$ Million)
Table 12: Percentage Breakdown of Global Interferons Market by Region for the Years 2008 & 2009
Table 13: Global Interleukins Market by Region for the Period 2007-2015 (Sales in US$ Million)
Table 14: Percentage Breakdown of Global Interleukins Market by Region for the Years 2008 & 2009
Table 15: Global Tissue Growth Factors Market by Region for the Period 2007-2015 (Sales in US$ Million)
Table 16: Percentage Breakdown of Global Tissue Growth Factors Market by Region for the Years 2008 & 2009
Table 17: Growth Factors (Blood and Tissue) Market by Type in the US: 2007-2015 (Sales in US$ Million)
Table 18: Percentage Breakdown of Growth Factors (Blood and Tissue) Market by Type in the US for the Years 2008 & 2009
Table 19: Growth Factors (Blood and Tissue) Market by Type in Japan: 2007-2015 (Sales in US$ Million)
Table 20: Percentage Breakdown of Growth Factors (Blood and Tissue) Market by Type in Japan for the Years 2008 & 2009
Table 21: Growth Factors (Blood and Tissue) Market by Type in Europe: 2007-2015 (Sales in US$ Million)
Table 22: Percentage Breakdown of Growth Factors (Blood and Tissue) Market by Type in Europe for the Years 2008 & 2009
Table 23: Growth Factors (Blood and Tissue) Market by Type in the Rest of World: 2007-2015 (Sales in US$ Million)
Table 24: Percentage Breakdown of Growth Factors (Blood and Tissue) Market by Type in the Rest of World for the Years 2008 & 2009
Companies Profiled