Markets for Advanced Wound Care Technologies (Market Research Report)

Chapter One: Introduction ........... 1
Study Goals And Objectives .......... 1
Reasons For Doing The Study ....... 1
Scope Of Report .......... 1
Methodology .......... 2
Previous Editions ........... 2
Related Bcc Market Research Reports ...... 3
Analyst Credentials .......... 3
Bcc Online Services ............ 4
Disclaimer ........... 4
Chapter Two: Summary ........... 5
Major Markets And Introduction ....... 5
Summary Table Total Advanced Wound Care Market By
Selected Segment, Through 2016 ($ Millions) .... 6
Summary Figure Total Advanced Wound Care Market By
Selected Segment, 2009-2016 ($ Millions) ...... 7
Chapter Three: Industry Overview .......... 8
Historical Wound Care Overview ........ 8
Historical Wound Care Overview (Continued) ...... 9
The Process Of Wound Healing ...... 10
Stages Of Healing ........ 11
Inflammatory Phase ........ 11
Destructive Phase ....... 12
Proliferative Phase .......... 12
Maturation ........ 13
Healing By Secondary Intention .... 13
Factors Affecting Wound Healing ....... 14
General Health Affecting Wound Healing ..... 14
Smoking ............ 14
Table 1 Percent Of Smokers In The U.S. Population 18 And
Older By Age And Sex, 2008 (%) ....... 15
Age ........... 16
Table 2 U.S. Population Estimates And Projections By
Age Group 1900-2050 (Thousands) ....... 17
Figure 1 U.S. Population Estimates And Projections By
Age Group 1900-2050 (Thousands) ....... 17
Table 3 Estimates Of Expected U.S. Life Expectancy At
Birth With Projections By Sex, 2000 And 2020 (Years) ..... 18
Figure 2 Estimates Of Expected U.S. Life Expectancy At
Birth With Projections By Sex, 2000 And 2020 (Years) ..... 18
Nutritional Status ...... 19
Table 4 Households And Persons Having Problems With
Access To Food, 2004-2008 ...... 19
Obesity ......... 19
Table 5 U.S. Age-Adjusted Percent Distribution Of Body
Mass Index (Bmi) Among Persons 18 Years And Over By
Selected Characteristics, 2007-2008 ........ 20
Fluid And Electrolyte Balance ........ 20
Immunosuppressed Or Compromised Individuals .. 21
Table 6 U.S. Incidence And Prevalence Of Select
Chronic Diseases Causing Immune System
Suppression, 2010 Estimates ......... 21
Figure 3 U.S. Prevalence Of Select Chronic Diseases
Causing Immune System Suppression, 2010 Estimates
(Million) .......... 21
Drugs ............ 22
Radiation Therapy ...... 22
Nutrition In Wound Healing ...... 22
Table 7 Patient History For Nutritional Assessment .... 23
Nutrition In Wound Healing (Continued) ..... 24
Complications Of Wound Healing ..... 25
Scarring ........ 25
Adhesions .......... 25
Dehiscence ........ 25
Evisceration ........... 26
Infection ............ 26
Hemorrhage ........... 26
Fistulas ........ 27
Wound Types And Demographics ........ 27
Acute Wounds ........ 28
Surgical Wounds/Incision .......... 28
Traumatic Wounds .......... 29
Lacerations ............ 29
Abrasions .......... 29
Contusions ........ 29
Necrotizing Fasciitis ........ 30
Toxic Epidermal Necrolysis ....... 30
Chronic Wounds .......... 31
Pressure Ulcers .......... 32
Table 8 Common Sites For Pressure Ulcer Development
(% Of Occurrence) .......... 33
• Staging ...... 34
Table 9 Pressure Ulcer Staging ......... 34
Venous Insufficiency Ulcers ..... 35
Arterial Ulcers ...... 35
Diabetic Or Neuropathic Ulcers ..... 36
Table 10 Estimated Diabetes Incidence By Age Group,
2010 ........... 36
Figure 4 Estimated Diabetes Incidence By Age Group,
2010 ........... 37
Burn Wounds ......... 38
Burn Classifications ........ 39
Table 11 Burn Classifications ......... 39
Stages Of Burn Healing ........ 40
Table 12 U.S. Incidence Of Surgical Procedures Causing
Wounds, 2010 ............ 41
Table 12 (Continued) ........... 42
Table 13 U.S. Incidence Of Selected Causes Of Wounds,
2010 ........... 42
Figure 5 U.S. Incidence Of Selected Conditions
Affecting The Wound Care Market (Thousands) .. 43
Table 14 Estimated Incidence By Age Group And Wound
Type (% Distribution) ......... 43
Figure 6 Estimated Incidence By Age Group And Wound
Type (% Distribution) ......... 44
The Aging U.S. Population ........ 44
Table 15 U.S. Population Estimates And Projections By
Age Group For Specific Years, 1900-2050 (Thousands) .... 45
Figure 7 U.S. Population Estimates And Projections, By
Age Group For Specific Years 1900-2050 (Thousands) ..... 45
Increasing Life Expectancy ....... 45
Table 16 Estimates Of Anticipated U.S. Life Expectancy
At Birth And Projections, By Gender, 2000-2020 ...... 46
Figure 8 Estimates Of Anticipated U.S. Life Expectancy
At Birth And Projections, By Gender, 1990-2050 (Years) ..... 46
Economic Impact Of Wounds And Wound Management ... 47
Government Regulation Of Devices ..... 47
International Developments In Wound Care ...... 48
Figure 9 Percent Distribution Of The Total Wound Care
Market By Region (%) .......... 49
Recent International Developments ....... 49
Table 17 Selected International Developments And
Approvals ............ 50
International Stem Cell Research ...... 51
International Stem ... (Continued) .... 52
International Stem ... (Continued) .... 52
Chapter Four: Issues Affecting The Market.... 53
Reimbursement Issues .......... 53
Military Wound Care ....... 54
Battlefield Wound Care ......... 54
Battlefield Wound Care (Continued) ....... 55
High-Tech Bandages ........ 56
High-Tech Bandages (Continued) ...... 57
Government Funded Development ........ 58
New Developments And Research ...... 58
Stem Cell Research ......... 58
Gene Therapy ........ 58
Light-Emitting Diodes ......... 59
Light-Emitting Diodes In Conjunction With Laser Diodes ... 60
Table 18 Select Companies Offering Light-Emitting
Diode Devices For Wound Care ........ 61
Table 18 (Continued) ........... 62
In Vivo Vs. In Vitro ......... 62
Table 19 Advantages Of In Vivo And In Vitro Tissue
Growth............. 62
In Vitro .......... 63
In Vivo ........ 64
Alternative Wound Care ......... 65
Maggot Therapy ....... 65
Maggot Therapy (Continued) ......... 66
Maggot Therapy (Continued) ......... 67
Reimbursement For Maggot Therapy ....... 68
Leech Therapy ........... 69
Ichthyotherapy ....... 69
Apitherapy ........ 69
Government Funded Research ....... 70
Alabama ......... 71
California ......... 71
Colorado ........... 71
Florida ........... 72
Georgia .......... 72
Illinois ........... 72
Maryland ........... 73
Massachusetts ......... 73
Michigan ........ 73
Missouri ......... 74
North Carolina ........ 74
Ohio ............. 74
Pennsylvania ........ 75
Rhode Island ......... 75
Texas .......... 76
Washington ........... 77
Technology ............ 77
Current Technology Uses...... 77
Negative Pressure Technology ....... 77
Tissue-Engineered Skin Substitutes ....... 78
Tissue Regeneration ........ 78
Acell-Matristem ...... 79
Patent Analysis ........ 79
Table 20 Wound Care Technology Patent Growth .. 80
Table 21 Wound Care Technology Patents By Year (1995-
2011*) .............. 80
Figure 10 Wound Care Technology Patents By Year (1995-
2011*) .............. 81
Table 22 U.S. Patent Evaluation Of Major Wound Care-
Related Technology By Patent Number 2011 ..... 82
Table 22 (Continued) ........... 83
Table 22 (Continued) ........... 84
Table 22 (Continued) ........... 85
Table 22 (Continued) ........... 86
Table 22 (Continued) ........... 87
Table 23 Advanced Wound Care Related Technologies By
Patent Holder, 2011* .......... 87
Figure 11 Advanced Wound Care Related Technologies
By Patent Holder, 2011* ......... 88
Current Technology Developers ..... 88
Kinetic Concepts Inc. ....... 89
Eastman Chemical Company ......... 89
Johnson & Johnson Vision Care, Inc. ...... 89
3m Innovative Properties Company ........ 89
Kimberly-Clark Worldwide, Inc. ........ 90
Renovo Limited ........... 90
Chapter Five: Market Segments .......... 91
Biological Dressings ....... 91
Biological Dressings (Continued) .... 92
Product Description ....... 93
Artificial Skin/Skin Replacement ....... 93
Table 24 Manufacturers Of Artificial Skin/Skin
Replacement Dressings 2011 ........ 93
Artificial Skin/... (Continued) ........ 94
Collagen Products ....... 95
Table 25 Manufacturers Of Collagen Dressings, 2011 .... 96
Collagen Products (Continued) ..... 97
Growth Factors ........... 98
Table 26 Manufacturers Of Growth Factor Dressings,
2011 ........... 98
Products In Development ...... 99
Table 27 Select Biologic Products In Development, 2011 ... 99
Market Analysis And Conclusion .... 100
Total Market And Segments ......... 100
Total Market And Segments (Continued) .. 101
Table 28 Estimated Market Revenues For Biological
Dressings By Product Segment, Through 2016 ($
Millions) ............ 102
Figure 12 Estimated Market Revenues For Biological
Dressings By Product Segment, 2011 And 2016 ($
Millions) ............ 102
Markets By Wound Type ......... 103
Table 29 Distribution Of Revenues For Biological
Dressings By Wound Type, 2011 ($ Millions) ....... 104
Figure 13 Distribution Of Revenues For Biological
Dressings By Wound Type, 2011 (%) ...... 104
Competitive Summary ........ 104
Competitive Summary (Continued) ...... 105
Table 30 Summary Of Biological Dressings Market By
Competitor Revenues, 2011 ($ Millions) .... 106
Figure 14 Summary Of Biological Dressings Market By
Competitor Revenues, 2011 ($ Millions) .... 106
Surgical Sealants And Glues ........ 107
Product Descriptions ........ 108
Table 31 Manufacturers Of Surgical Sealants And
Glues, 2011 ......... 108
Product Descriptions (Continued) .... 109
Product Descriptions (Continued) .... 110
Products In Development ......... 111
Table 32 Select Surgical/Vascular Sealant Products
In Development ........ 111
Market Analysis And Conclusions ...... 112
Total Market And Segments ......... 112
Table 33 Estimated Market Revenues For Surgical
Sealants And Glues, Through 2016 ($ Millions) ... 112
Figure 15 Estimated Market Revenues For Surgical
Sealants And Glues, 2009-2016 ($ Millions) ..... 113
Competitive Summary ........ 113
Table 34 Summary Of The Surgical Sealants And Glues
Market By Competitor Revenues, 2011 ($ Millions) ...... 114
Figure 16 Summary Of The Surgical Sealants And Glues
Market By Competitor Revenues, 2011 ($ Millions) ...... 115
Synthetic Dressings....... 115
Product Description .......... 115
Alginate Dressings ......... 116
Table 35 Alginate Dressing Manufacturers, 2011 .. 116
Table 35 (Continued) ......... 117
Alginate Dressings (Continued) ....... 118
Alginate Dressings (Continued) ....... 119
Film Dressings .......... 120
Table 36 Film Dressing Manufacturers, 2011 ....... 121
Film Dressings (Continued) ........ 122
Film Dressings (Continued) ........ 123
Foam Dressings ........ 124
Table 37 Foam Dressing Manufacturers, 2011 ...... 125
Foam Dressings (Continued) ....... 126
Foam Dressings (Continued) ....... 127
Hydrocolloid Dressings ....... 128
Table 38 Hydrocolloid Dressing Manufacturers, 2011 ...... 129
Hydrocolloid Dressings (Continued) ..... 130
Hydrocolloid Dressings (Continued) ..... 131
Hydrogel Dressings ....... 132
Table 39 Hydrogel Dressing Manufacturers, 2011 ..... 132
Table 39 (Continued) ......... 133
Hydrogel Dressings (Continued) ...... 134
Hydrogel Dressings (Continued) ...... 135
Market Analysis And Conclusion .... 136
Total Market And Segments ......... 136
Total Market And Segments (Continued) .. 137
Table 40 Estimated Market Revenues For Synthetic
Dressings By Product Segment, Through 2016 ($
Millions) ............ 138
Figure 17 Estimated Market Revenues For Synthetic
Dressings By Product Segment, 2009-2016 ($ Millions) ..... 139
Markets By Wound Type ......... 139
Table 41 Revenue Distribution For Synthetic Dressings
By Wound Type, 2011 ($ Millions) .......... 140
Figure 18 Revenue Distribution For Synthetic
Dressings By Wound Type, 2011 (%) ...... 140
Competitive Summary ........ 141
Table 42 Summary Of The Synthetic Dressings Market By
Competitor Revenues, 2011 ($ Millions) .... 142
Figure 19 Summary Of The Synthetic Dressings Market
By Competitor Revenues, 2011 ($ Millions) ........ 142
Anti-Adhesion And Other Related Wound-Healing
Products .......... 142
Anti-Adhesion Products ....... 143
Enzymatic/Hypertonic Saline Debriding Agents .. 143
Product Description .......... 144
Table 43 Manufacturers Of Anti-Adhesion And Other
Advanced Wound Care Products, 2011 ....... 144
Adhesion Barriers .......... 144
Table 44 Surgeon Experiences With The Three Leading
Adhesion Barriers In The United States ..... 145
Other Products .......... 146
Products In Development ......... 146
Table 45 Select Anti-Adhesion Products And Other
Advanced Wound Care Products In Development .. 147
Market Analysis And Conclusions ...... 148
Total Market And Segments ......... 148
Table 46 Estimated Market For Anti-Adhesion And Other
Wound Healing Products By Segment, Through 2016 ($
Millions) ............ 149
Figure 20 Estimated Market For Anti-Adhesion And
Other Wound-Healing Products By Segment, 2009-2016
($ Millions) ........ 149
Markets By Wound Type ......... 149
Table 47 Revenue Distribution For Anti-Adhesion And
Other Wound Healing Products By Wound Type, 2011 ($
Millions) ............ 150
Figure 21 Revenue Distribution For Anti-Adhesion And
Other Wound Healing Products By Wound Type, 2011 (%) .... 151
Competitive Summary ........ 151
Table 48 Summary Of Anti-Adhesion And Other Wound
Healing Markets By Competitor Revenues, 2011 ($
Millions) ............ 152
Figure 22 Summary Of Anti-Adhesion And Other Wound
Healing Markets By Competitor Revenues, 2011 ($
Millions) ............ 152
Wound Healing Devices .......... 153
Product Descriptions ........ 153
Table 49 Advanced Wound Healing Device
Manufacturers, 2011 ........ 153
Table 49 (Continued) ......... 154
Electrical Stimulation Devices And Electromagnetic
Therapy ........... 154
Electromagnetic Therapy ........ 154
Negative Pressure Wound Therapy (Npwt) Or Vacuum-
Assisted Closure (Vac) ...... 155
Negative Pressure ... (Continued) .... 156
Hyperbaric Oxygen Devices ......... 157
Epiflo (Transdermal Sustained Oxygen Delivery) ... 158
Radio Frequency (Rf) Stimulus ........ 158
External Tissue Expander (Proxiderm) ...... 159
Ultrasonic Wound Debridement ....... 159
Led Therapy ....... 160
Other Devices ....... 160
Clinical Trials ........... 161
Market Analysis And Conclusion .... 161
Total Market And Segments ......... 161
Table 50 Estimated Market For Wound Healing Devices
By Product Segment, Through 2016 ($ Millions) .. 162
Figure 23 Estimated Market For Wound Healing Devices
By Product Segment, 2009-2016 ($ Millions) ........ 162
Markets By Wound Type ......... 163
Table 51 Revenue Distribution For Wound Healing
Devices By Wound Type, 2011 ($ Millions) ........ 163
Figure 24 Revenue Distribution For Wound Healing
Devices By Wound Type, 2011 (%) ....... 164
Competitive Summary ........ 164
Table 52 Summary Of The U.S. Wound Healing Device
Market By Competitor Revenues, 2011 ($ Millions) ...... 165
Figure 25 Summary Of The Wound Healing Device Market
By Competitor Revenues, 2011 ($ Millions) ........ 165
Chapter Six: Market Summary ....... 166
Figure 26 Traditional Vs. Advanced Wound Care
Treatment Revenues, U.S. Market, 2009-2016 ($ Millions) .... 166
Total Advanced Wound Care Market Analysis .. 167
Table 53 Analysis Of Total U.S. Market For Advanced
Wound Care Products By Type, Through 2016 ($
Millions) ............ 167
Figure 27 Analysis Of Total U.S. Market For Advanced
Wound Care Products By Type, 2009-2016 ($ Millions) ... 168
Markets By Wound Type ......... 168
Table 54 Revenue Distribution By Type Of Advanced
Wound Care, 2011 ($ Millions) ...... 169
Figure 28 Revenue Distribution By Type Of Advanced
Wound Care, 2011 (%) .......... 170
Industry Participants By Type ...... 170
Table 55 Major Industry Participants By Product Type ... 170
Table 55 (Continued) ......... 171
Table 55 (Continued) ......... 172
Figure 29 Distribution Of Major Industry Players By
Product Segment Participation ........ 172
Figure 29 (Continued) ........... 173
Chapter Seven: Company Profiles And Snapshots ..... 174
Company Profiles ............ 174
3m Health Care ....... 174
Bard Medical Division ........ 175
Baxter International, Inc ......... 175
Coloplast A/S ........... 176
Convatec, Inc. .......... 177
Covidien Plc ........ 177
Derma Sciences, Inc. ....... 178
Ethicon, Inc. ........ 179
Genzyme Biosurgery-A Sanofi Company ...... 179
Integra Life Sciences Corp ....... 180
Kinetic Concepts, Inc. (Lifecell) ...... 181
Organogenesis, Inc. ........ 182
Smith & Nephew Plc ........ 182
Company Snapshots ........ 183
Advanced Biohealing Inc. (A Shire Company) ...... 183
Covalon Technologies Ltd. ...... 183
Cryolife, Inc. ........... 184
Hartmann Ag ............ 184
Mölnlycke Health Care ........ 184
St Jude Medical, Inc. ...... 184
Synovis Life Technologies, Inc. ........ 185
Systagenix ........... 185
Tei Biosciences, Inc. ....... 185
Z-Medica Corporation ........ 185
Appendix: Company Listings ........ 186
Company Listings ........ 186
Company Listings (Continued) ...... 187
Company Listings (Continued) ...... 188
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Company Listings (Continued) ...... 196
Company Listings (Continued) ...... 197