Orthobiologics Market to 2016 - Alternatives to Surgery and Superior Outcomes are Driving Wider Adoption of Orthobiologics

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Market	Healthcare and Medical
Report Type	Market Research
Country	Global
Published	25 June 2011
Number of Pages	81
Report Delivery	Email
Delivery Lead Time	1-3 hours, 24 hour max
Publisher	GBI Research
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The global orthobiologics market was valued at $4.3 billion in 2009, and is forecast to reach $9.6 billion in 2016, which represents a compound annual growth rate (CAGR) of 12%. Bone graft substitutes will remain the largest segment in the market, with a value of $5.3 billion by 2016. Growth in the market is primarily being driven by the increasing incidence of arthritis, an increasingly elderly population, and higher obesity rates. Globally, about 350 million people have arthritis, and more than half of those with arthritis, are under 65 years of age. Also, advances in technology, such as the development of nanotechnology coatings for use in wear-resistant orthopedic devices, and injectable bones, which are biodegradable and can fill any cavity shape, taking on similar characteristics to normal bone, are expected to drive the market in the near future.

The US Remains the Largest Orthobiologics Market, Driven by Increasing Patient Awareness and Active Lifestyles Leading to Higher Numbers of Injuries

The US orthobiologics market was valued at $2.3 billion in 2009, and is expected to reach $6 billion in 2016, which represents a CAGR of 15% for the period. The US remains the largest orthobiologics market in the world, accounting for more than 50% of the global orthobiologics market in 2009. The orthobiologics market in the US going forwards is expected to be driven by patient demographics, the development of novel product designs, increasing patient awareness, increasing participation in sports related activities, and a rising incidence of road accidents.

Increasing Incidence of Arthritis and Other Orthopedic Diseases to Drive the Market

The incidence of arthritis has been growing steadily, mainly due to an increase in obesity rates and an increase in the population over the age of 65. Studies have shown that more than 50% of people over 65 years of age, go on to develop osteoarthritis, and worldwide, 350 million people have arthritis. According to the US Centre of Disease Control (CDC), 47.8 million people in the US were affected by some form of arthritis during 2005. It is projected that by 2030, physician-diagnosed arthritis will reach 67 million, or 25% of the adult population. Also, the prevalence of back pain is increasing, and is estimated to be highest among middle aged individuals, between 30 to 50 years old. The annual incidence of lower back pain in the US and Europe is approximately 5% of the total population. Worldwide, 200 million people are at risk of a fragility fracture, and 40% of women and 14% of men older than 50 years, will experience a fragility fracture.

Numbers suffering from orthopedic diseases are expected to grow in developing countries, due to people leading more sedentary lives, changes in diet, and urbanization, which all lead to increasing obesity rates, and ultimately to arthritis and other orthopedic diseases. Obesity rates have increased globally over the past few decades, with currently more than one billion adults overweight worldwide, and at increased risk of developing arthritis.

Technological Advances Leading to the Introduction of Improved Products to Drive the Orthobiologics Market

The orthobiologics product pipeline is strong, with about 134 products making their way to market. These products are aimed at reducing rejection rates, stimulating the growth of bone and improving patient outcomes. The advantages offered and the simplicity in use of many of these pipeline products, is expected to increase their uptake. Nanotechnology will be the key driver of growth in the orthobiologics market in the near future.

There are products in the pipeline which have nanotechnology coatings, for use in wear-resistant orthopedic devices, specifically for spinal implants. Due to this coating, the products offer a higher level of durability, thus increasing demand for them. Also, companies are developing injectable bones which are biodegradable, and are able to stabilize fractured bones, offering superior strength, rapid setting and mouldable properties.

Products offering greater durability, reductions in inflammation, and which improve the quality of life, are expected to drive future demand for orthobiologics.

Medtronic, Genzyme and Depuy with a Combined Market Share of Nearly 40%, Dominate the Global Orthobiologics Market

The global orthobiologics market was dominated by Medtronic, Genzyme and Depuy, which together accounted for nearly 40% of the total market in 2009. Medtronic is the market leader, with a 19% share in 2009. Medtronic's InFUSE bone graft was its major revenue generator in the orthobiologics market during the first quarter of 2009. Genzyme was the second largest company, with a market share of 11%, followed by Depuy with 10%. Synvisc-One, the only single-injection viscosupplement for osteoarthritic knee pain approved in the U.S., was the major revenue generator for Genzyme in 2009.

Report overview

This report provides key data, information and analysis on the Orthobiologics industry and analytical content on the market dynamics. The report provides market landscape, competitive landscape and market trends information on Orthobiologics industry . The report provides comprehensive information on the current practices and trends in the Orthobiologics industry. The report also reviews the competitive landscape, and technology offerings. This report is built using data and information sourced from proprietary databases, primary and secondary research and in-house analysis by our team of industry experts.

Scope

- Key geographies covered include the US, Canada, the UK, Germany, France, Italy, Spain, Japan, China, India, Australia, and Brazil.
- Market size and company share data for Orthobiologics.
- Annualized market revenues data from 2002 to 2009, forecast forward for 7 years to 2016. Company shares data for 2009..
- Qualitative analysis of key market trends, market drivers, and restraints by each category within the Orthobiologics market.
- The report also covers information on the leading market players, the competitive landscape, and the leading technologies.

Reasons to buy

- Develop business strategies by understanding the trends and developments that are driving the Orthobilogics market globally.
- Design and develop your product development, marketing and sales strategies.
- Exploit M&A opportunities by identifying market players with the most innovative pipeline.
- Develop market-entry and market expansion strategies.
- Identify key players best positioned to take advantage of the emerging market opportunities.
- Exploit in-licensing and out-licensing opportunities by identifying products, most likely to ensure a robust return.
- What's the next being thing in the Orthobilogics market? - Identify, understand and capitalize.
- Make more informed business decisions from the insightful and in-depth analysis of the global Orthobilogics market and the factors shaping it.

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1 Table of Contents
1 Table of Contents 3
1.1 List of Tables 5
1.2 List of Figures 6

2 Introduction 7
2.1 GBI Research Guidance 7

3 Overview: Orthobiologics 8
3.1 Applications of Orthobiologics 8

4 Global Orthobiologics : Market Characterization 10
4.1 Global Orthobiologics Market, Revenue ($m), 2002 - 2009 10
4.2 Global Orthobiologics Market, Revenue Forecast ($m), 2009-2016 12
4.3 Global Orthobiologics Market, Key Company Shares (%), 2009 13
4.4 Global Orthobiologics Market, Dynamics 15
4.4.1 Market Drivers 15
4.4.2 Market Restraints 16

5 Global Orthobiologics Market: Category Analysis and Forecasts 17
5.1 Global Bone Graft Substitutes Market, Revenue ($m), Historic, 2002 - 2009 17
5.2 Global Bone Graft Substitutes Market, Revenue ($m), Forecast, 2009 - 2016 18
5.2.1 Bone Graft Substitutes, Market Drivers 19
5.2.2 Bone Graft Substitutes, Market Restraint 19
5.3 Global Viscosupplementation Market, Revenue ($m), Historic, 2002 - 2009 20
5.4 Global Viscosupplementation Market, Revenue ($m), Forecast, 2009 - 2016 21
5.4.1 Viscosupplementation, Market Drivers 22
5.4.2 Viscosupplementation, Market Restraint 22
5.5 Global DBM Market, Revenue ($m), Historic, 2002 - 2009 23
5.6 Global DBM Market, Revenue ($m), Forecast, 2009 - 2016 24
5.6.1 DBM, Market Drivers 25
5.6.2 DBM, Market Restraint 25
5.7 Global Bone Growth Stimulators Market, Revenues ($m), Historic, 2002 - 2009 26
5.8 Global Bone Growth Stimulators Market, Revenues ($m), Forecast, 2009 - 2016 27
5.8.1 Bone Growth Stimulators, Market Driver 28
5.8.2 Bone Growth Stimulators, Market Restraint 28
5.9 Global Bone Allografts Market, Revenue ($m), Historic, 2002-2009 29
5.10 Global Bone Allografts Market, Revenue ($m), Forecast, 2009-2016 30

6 Global Orthobiologics Market: Country Analysis and Forecasts 31
6.1 Historic (2002-2009) and Forecast (2009-2016) Revenue, By Country 31
6.1.1 Orthobiologics Market, the US, Revenue ($m), 2002 - 2009 31
6.1.2 Orthobiologics Market, the US, Revenue ($m), 2009 - 2016 32
6.1.3 Orthobiologics Market, Canada, Revenue ($m), 2002-2009 33
6.1.4 Orthobiologics Market, Canada, Revenue ($m), 2009-2016 34
6.1.5 Orthobiologics Market, the UK, Revenue ($m), 2002-2009 35
6.1.6 Orthobiologics Market, the UK, Revenue ($m), 2009-2016 36
6.1.7 Orthobiologics Market, Germany, Revenue ($m), 2002 - 2009 37
6.1.8 Orthobiologics Market, Germany, Revenue ($m), 2009-2016 38
6.1.9 Orthobiologics Market, France, Revenue ($m), 2002-2009 39
6.1.10 Orthobiologics Market, France, Revenue ($m), 2009-2016 40
6.1.11 Orthobiologics Market, Italy, Revenue ($m), 2002-2009 41
6.1.12 Orthobiologics Market, Italy, Revenue ($m), 2009-2016 42
6.1.13 Orthobiologics Market, Spain, Revenue ($m), 2002-2009 43
6.1.14 Orthobiologics Market, Spain, Revenue ($m), 2009-2016 44
6.1.15 Orthobiologics Market, Brazil, Revenue ($m), 2002-2009 45
6.1.16 Orthobiologics Market, Brazil, Revenue ($m), 2009-2016 46
6.1.17 Orthobiologics Market, Japan, Revenue ($m), 2002-2009 47
6.1.18 Orthobiologics Market, Japan, Revenue ($m), 2009-2016 48
6.1.19 Orthobiologics Market, China, Revenue ($m), 2002-2009 49
6.1.20 Orthobiologics Market, China, Revenue ($m), 2009-2016 50
6.1.21 Orthobiologics Market, India, Revenue ($m), 2002-2009 51
6.1.22 Orthobiologics Market, India, Revenue ($m), 2009-2016 52
6.1.23 Orthobiologics Market, Australia, Revenue ($m), 2002-2009 53
6.1.24 Orthobiologics Market, Australia, Revenue ($m), 2009-2016 54

7 Global Orthobiologics Market: Competitive Assessment 55
7.1 Medtronic Inc. 55
7.1.1 Overview: 55
7.2 Genzyme Corporation 56
7.2.1 Overview 56
7.3 Depuy, Inc.(Johnson & Johnson) 56
7.3.1 Overview 56
7.4 Synthes, Inc. 57
7.4.1 Overview 57
7.5 Smith & Nephew Plc 58
7.5.1 Overview 58
7.6 Stryker 59
7.6.1 Overview 59
7.7 Orthofix International N.V 60
7.7.1 Overview 60

8 Global Orthobiologics Market: Product Pipeline Analysis 61
8.1 Orthobiologics Market: Pipeline Products Summary 61
8.2 Profiles of Promising Products Under Clinical Development: 63
8.2.1 Synthetic Bone Graft Substitutes 63
8.2.2 BMP 65
8.2.3 Bone Growth Stimulators 66
8.2.4 Bone Allograft 68
8.2.5 Viscosupplementation 68
8.2.6 DBM 69
8.3 List of Pipeline Products 69
8.3.1 Pipeline Product Summary 69

9 Global Orthobiologics Market: Consolidation Landscape 73
9.1 Key Deals 75
9.1.1 Medtronic to Acquire Osteotech 75
9.1.2 Landec Acquires Lifecore Biomedical 75
9.1.3 Baxter International Completes Acquisition Of ApaTech 76
9.1.4 TiGenix Completes Acquisition Of OrthoMimetics 76
9.1.5 NuVasive Invests In Progentix Orthobiology 76
9.1.6 Kinetic Concepts Acquires LifeCell 77
9.1.7 Pioneer Surgical Acquires Angstrom Medica 77
9.1.8 Pioneer Surgical Technology Acquires Encelle 77
9.1.9 Orthofix Acquires Blackstone Medical 77

10 Appendix 78
10.1 Definitions 78
10.1.1 Orthobiologics 78
10.2 Acronyms 78
10.3 Sources 79
10.4 Research Methodology 79
10.4.1 Secondary Research 79
10.4.2 Primary Research 79
10.4.3 Models 80
10.4.4 Forecasts 80
10.4.5 Expert Panels 80
10.5 Contact Us 81
10.6 Disclaimer 81

List of Tables

Table 1: Global Orthobiologics Market, Revenue ($m), 2002 - 2009 10
Table 2: Global Orthobiologics Market, Revenue Forecast ($m), 2009 - 2016 12
Table 3: Global Orthobiologics Market, Key Company Share (Revenue $m), 2009 13
Table 4: Global Bone Graft Substitutes Market, Revenue ($m), Historic 2002 - 2009 17
Table 5: Global Bone Graft Substitutes Market, Revenue ($m), Forecast 2009 - 2016 18
Table 6: Global Viscosupplementation Market Revenue ($m), Historic, 2002 - 2009 20
Table 7: Global Viscosupplementation Market, Revenue ($m), Forecast, 2009 - 2016 21
Table 8: Global DBM Market, Revenue ($m), Historic, 2002 - 2009 23
Table 9: Global DBM Market, Revenue ($m), Forecast, 2009 - 2016 24
Table 10: Global Bone Growth Stimulators Market, Revenue ($m), Historic , 2002 - 2009 26
Table 11: Global Bone Growth Stimulators Market, Revenues ($m), Forecast 2009 - 2016 27
Table 12: Global Bone Allografts Market, Revenue ($m), Historic, 2002 - 2009 29
Table 13: Global Bone Allografts Market, Revenue ($m), Forecast, 2009 - 2016 30
Table 14: Orthobiologics Market, the US, Revenue ($m), 2002-2009 31
Table 15: Orthobiologics Market, the US, Revenue ($m), 2009-2016 32
Table 16: Orthobiologics Market, Canada, Revenue ($m), 2002-2009 33
Table 17: Orthobiologics Market, Canada, Revenue ($m), 2009-2016 34
Table 18: Orthobiologics Market, the UK, Revenue ($m), 2002-2009 35
Table 19: Orthobiologics Market, the UK, Revenue ($m), 2009-2016 36
Table 20: Orthobiologics Market, Germany, Revenue ($m), 2002-2009 37
Table 21: Orthobiologics Market, Germany, Revenue ($m), 2009-2016 38
Table 22: Orthobiologics Market, France, Revenue ($m), 2002-2009 39
Table 23: Orthobiologics Market, France, Revenue ($m), 2009-2016 40
Table 24: Orthobiologics Market, Italy, Revenue ($m), 2002-2009 41
Table 25: Orthobiologics Market, Italy, Revenue ($m), 2009-2016 42
Table 26: Orthobiologics Market, Spain, Revenue ($m), 2002-2009 43
Table 27: Orthobiologics Market, Spain, Revenue ($m), 2009-2016 44
Table 28: Orthobiologics Market, Brazil, Revenue ($m), 2002-2009 45
Table 29: Orthobiologics Market, Brazil, Revenue ($m), 2009-2016 46
Table 30: Orthobiologics Market, Japan, Revenue ($m), 2002-2009 47
Table 31: Orthobiologics Market, Japan, Revenue ($m), 2009-2016 48
Table 32: Orthobiologics Market, China, Revenue ($m), 2002-2009 49
Table 33: Orthobiologics Market, China, Revenue ($m), 2009-2016 50
Table 34: Orthobiologics Market, India, Revenue ($m), 2002-2009 51
Table 35: Orthobiologics Market, India, Revenue ($m), 2009-2016 52
Table 36: Orthobiologics Market, Australia, Revenue ($m), 2002-2009 53
Table 37: Orthobiologics Market, Australia, Revenue ($m), 2009-2016 54
Table 38: Medtronic, Inc. , Marketed Products, 2010 55
Table 39: Genzyme Corporation, Marketed Products, 2010 56
Table 40: Depuy, Marketed Products, 2010 56
Table 41: Synthes, Inc, Marketed Products, 2010 57
Table 42: Smith & Nephew, Marketed Products, 2010 58
Table 43: Stryker, Marketed Products, 2010 59
Table 44: Orthofix International, Marketed Products, 2010 60
Table 45: Pipeline Products, Orthobiologics, by Development Stage, Global, 2010 61
Table 46: Pipeline Products, Orthobiologics, by Segment, Global, 2010 62
Table 47: To Evaluate The Safety And Effectiveness Of GEM OS1 Compared To Autologous Bone Graft As A Bone Regeneration Device In Foot And Ankle Fusions 63
Table 48: The Efficacy Of rhBMP-2 For Posterolateral Lumbar Fusion In Smokers 65
Table 49: Orthobiologics, Pipeline Products, BMP, 2010 69
Table 50: Orthobiologics, Pipeline Products, Bone Allografts, 2010 70
Table 51: Orthobiologics, Pipeline Products, Bone Graft Substitutes, 2010 70
Table 52: Orthobiologics, Pipeline Products, Bone Growth Stimulators, 2010 71
Table 53: Orthobiologics, Pipeline Products, DBM, 2010 71
Table 54: Orthobiologics, Pipeline Products, Viscosupplementation, 2010 72
Table 55: Orthobiologics Market, Key Deals, 2006-2010* 73

List of Figures

Figure 1: Global Orthobiologics Market, Revenue ($m), 2002 - 2009 10
Figure 2: Global Orthobiologics Market, Revenue Forecast ($m), 2009 - 2016 12
Figure 3: Global Orthobiologics Market, Key Company Shares (%), 2009 13
Figure 4: Global Bone Graft Substitutes Market, Revenue ($m), Historic 2002 - 2009 17
Figure 5: Global Bone Graft Substitutes Market, Revenue ($m), Forecast 2009 - 2016 18
Figure 6: Global Viscosupplementation Market Revenue ($m), Historic, 2002 - 2009 20
Figure 7: Global Viscosupplementation Market, Revenue ($m), Forecast, 2009 - 2016 21
Figure 8: Global DBM Market, Revenue ($m), Historic, 2002 - 2009 23
Figure 9: Global DBM Market, Revenue ($m), Forecast, 2009 - 2016 24
Figure 10: Global Bone Growth Stimulators Market, Revenue ($m), Historic , 2002 - 2009 26
Figure 11: Global Bone Growth Stimulators Market, Revenues ($m), Forecast 2009 - 2016 27
Figure 12: Global Bone Allografts Market, Revenue ($m), Historic, 2002 - 2009 29
Figure 13: Global Bone Allografts Market, Revenue ($m), Forecast, 2009 - 2016 30
Figure 14: Orthobiologics Market, the US, Revenue ($m), 2002-2009 31
Figure 15: Orthobiologics Market, the US, Revenue ($m), 2009-2016 32
Figure 16: Orthobiologics Market, Canada, Revenue ($m), 2002-2009 33
Figure 17: Orthobiologics Market, Canada, Revenue ($m), 2009-2016 34
Figure 18: Orthobiologics Market, the UK, Revenue ($m), 2002-2009 35
Figure 19: Orthobiologics Market, the UK, Revenue ($m), 2009-2016 36
Figure 20: Orthobiologics Market, Germany, Revenue ($m), 2002-2009 37
Figure 21: Orthobiologics Market, Germany, Revenue ($m), 2009-2016 38
Figure 22: Orthobiologics Market, France, Revenue ($m), 2002-2009 39
Figure 23: Orthobiologics Market, France, Revenue ($m), 2009-2016 40
Figure 24: Orthobiologics Market, Italy, Revenue ($m), 2002-2009 41
Figure 25: Orthobiologics Market, Italy, Revenue ($m), 2009-2016 42
Figure 26: Orthobiologics Market, Spain, Revenue ($m), 2002-2009 43
Figure 27: Orthobiologics Market, Spain, Revenue ($m), 2009-2016 44
Figure 28: Orthobiologics Market, Brazil, Revenue ($m), 2002-2009 45
Figure 29: Orthobiologics Market, Brazil, Revenue ($m), 2009-2016 46
Figure 30: Orthobiologics Market, Japan, Revenue ($m), 2002-2009 47
Figure 31: Orthobiologics Market, Japan, Revenue ($m), 2009-2016 48
Figure 32: Orthobiologics Market, China, Revenue ($m), 2002-2009 49
Figure 33: Orthobiologics Market, China, Revenue ($m), 2009-2016 50
Figure 34: Orthobiologics Market, India, Revenue ($m), 2002-2009 51
Figure 35: Orthobiologics Market, India, Revenue ($m), 2009-2016 52
Figure 36: Orthobiologics Market, Australia, Revenue ($m), 2002-2009 53
Figure 37: Orthobiologics Market, Australia, Revenue ($m), 2009-2016 54
Figure 38: Medtronic, Inc. , Pipeline Products, 2010 55
Figure 39: Depuy, Pipeline Products, 2010 56
Figure 40: Smith & Nephew , Pipeline Products, 2010 58
Figure 41: Stryker , Pipeline Products, 2010 59
Figure 42: Orthofix International , Pipeline Products, 2010 60
Figure 43: Pipeline Products, Orthobiologics, by Development Stage, Global, 2010 61
Figure 44: Pipeline Products, Orthobiologics, by Segment, Global, 2010 62
Figure 45: Orthobiologics Market Deal Analysis, Value ($m) and Volume, 2006-2010 73

Companies Mentioned

Medtronic Inc.
Genzyme Corporation
Depuy, Inc.(Johnson & Johnson)
Synthes, Inc.
Smith & Nephew Plc
Stryker
Orthofix International N.V

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