Table of Contents
Global bioinformatics market
Executive summary 20
Market overview 20
Competitive landscape & market dynamics 21
The bioinformatics tools market 22
The bioinformatics 22
The bioinformatics service market 23
The bioinformatics 24
Regional analysis of the bioinformatics 24
Company profiles 25
Chapter 1 Market overview 28
Summary 28
Introduction 29
Defining the bioinformatics market 30
Market evolution increases use of bioinformatics 32
Bioinformatics and drug development 33
Sequencing tools are high priority 37
Bioinformatics database management tools 38
Bioinformatics patent analysis 40
Genomics remains the key segment 40
High market presence of Japanese market players 41
Bioinformatics service outsourcing shifting to Asian markets 42
Market Size 43
Chapter 2 Competitive landscape & market dynamics 46
Summary 46
Introduction 47
Competitive landscape 47
Recent mergers and acquisitions 48
Recent product, technology and service launches 49
Market drivers 54
Need for integrated data-handling tools for drug discovery 54
Growth in genomics and proteomics industry 54
Wide applications in drug discovery and development 54
Government support for R&D 55
Biomarker discovery enables the development of safe drugs 55
Developments in internet and IT 55
Emergence of high-throughput screening 55
Other drivers 56
Resistors of market growth 57
Common, well-defined data formats are needed 57
Need for trained resources compound operational costs 57
Saturation of pharmaceutical markets reduces adoption rate 57
Restricted range of product/service offerings 57
Other restraints to market growth 58
Growth opportunities 58
Pressure to escalate drug research productivity 58
Drug development value chain to widen opportunities 58
High market demand for integrated systems and solutions 58
Chemogenomics poses vast opportunity for growth 59
Applications in diversified areas to expand the user base 59
Data overload in the field of research 59
Chapter 3 The bioinformatics tools market 62
Summary 62
Introduction 63
Growth drivers 66
Need for better output quality in drug discovery 66
Integration of bioinformatics resources 66
Application of bioinformatic tools in the life sciences market 66
Resistors of growth 67
Complex operations of bioinformatic tools restricts growth 67
High price of analytical solutions may not be feasible 67
Sequence analysis tools 67
DNA sequence analysis tools 71
Sequence alignment 72
Gene detection 72
Restriction, and repeats and unusual patterns detection 73
Transcriptional elements detection 73
tRNA detection 74
Protein function assignment 74
Protein-protein interaction 76
Pattern, motif, profiles, domains and families search 76
Search, computation and analysis of pathways 77
Protein annotation 77
Automatic alerts for related new sequences 78
3D structure analysis and modeling tools 78
3D viewers 79
3D homology modeling 79
3D analysis 80
RNA analysis tool 81
Microarray data analysis 81
Phylogenetic analysis 82
Multiple sequence alignment 82
Organism classification 83
Sequence alignment tools 84
Sequence analysis (alignment) 86
Multiple sequence alignment 87
Phylogenetic tree building 87
Consensus sequence and translation 88
Lab end-sequence analysis 89
Primer design 90
Cloning 90
Contig assembly 91
Sequence manipulation tools 91
Sequence analysis (including sequence manipulation) 92
Sequence manipulation 93
Format conversion 94
Random sequences 94
Structural analysis tools 95
Sequence visualization tools 96
3D protein structure 97
Dot plots 97
Graphical and phylogenetic tree viewers and editors 98
Primary sequence analysis 99
Physicochemical property alignment 99
Alignment tools 100
Predicting secondary structure sequences 100
Other bioinformatics tools 101
Visualization tools 102
Database viewers 103
Sequence viewers 103
Molecular viewers 104
Physical mapping software 105
Chapter 4 The bioinformatics content/database market 108
Summary 108
Introduction 109
Growth drivers 111
Exponential growth in the proteomics data and databases 111
Data integration devices needed for in-house solutions 111
Growth in the clinical trials industry supports the market 112
Specialized databases 112
Specialized sequence databases 114
Genome databases 114
Collections 116
Model organism databases 116
Specialized protein databases 117
Proteome databases 118
Protein classification databases 119
Specific protein family databases 119
Specialized structural databases 120
Microarray databases 120
Pathways databases 121
2D-PAGE databases 122
General databases 122
Primary sequence databases 124
Protein sequence databases 124
3D structure databases 125
Carbohydrate databases 125
Chapter 5 The bioinformatics services market 128
Summary 128
Introduction 129
Growth drivers 130
Growing trend towards consultancy 130
Requirement for highly efficient data-mining tools 131
Need for total integration & warehousing solutions 131
Data analysis services 132
Genomics data analysis 134
Proteomics data analysis 134
Microarray data analysis 135
Modeling & computational bioinformatics services 136
Sequencing services 136
High-throughput screening 138
Multiple sequence alignment 139
Resequencing (SNP profiling) 139
Primer walking 140
Expression profile clustering 140
Shotgun sequencing 141
Database management services 142
Conception and realization 144
Development of user interface 144
Maintenance 145
Backup systems 145
Migration 145
Other services 146
Security systems 147
Data-mining services 148
Infrastructure integration services 149
Knowledge management 150
Chapter 6 The bioinformatics applications market 152
Summary 152
Introduction 153
Global market dynamics 153
Growth drivers 154
Rapid development of molecular diagnostics market 154
Development in personalized medicine 154
Specific medicines developed to treat the source of disease 155
Resistors of growth 155
Need for more holistic solutions 155
Bioinformatics considered to be for specialized applications only 155
Opportunities 156
Application in the military 156
Bioinformatics in epidemiology 156
Integration of systems biology with bioinformatics 156
Molecular medicine 157
Global market 158
US 159
Europe 160
Asia 160
Preventive medicine 161
Gene therapy 162
Growth drivers 163
Biomarker discovery helps gene therapy to determine disease candidates 163
Demand for gene therapy treatment necessitates bioinformatics application 163
Opportunities 164
Data proliferation in the field of gene therapy 164
Declining growth of gene therapy market 164
Drug development 164
Growth drivers 165
Drastic cost reduction in the process of drug discovery 165
Data processing needs in the drug development process 165
Virtual high-throughput screening 166
Sequence analysis 166
Similarity searches 166
Drug lead optimization 166
Physicochemical modeling 167
Drug bioavailability and bioactivity 167
Other applications 167
Chapter 7 Regional analysis of the bioinformatics market 172
Summary 172
Introduction 173
North America 173
Europe 174
Asia 175
India and China 176
The Indian bioinformatics industry 178
Business opportunities in India and China 182
Growth drivers 183
Growth resistors 184
Rest of the World 185
Chapter 8 Company profiles 188
Summary 188
3rd Millennium Inc. 189
Company overview 189
Products and services 189
Company strategy 190
Accelrys, Inc. 191
Company overview 191
Products and services 191
Company strategy 191
Affymetrix 192
Company overview 192
Products and services 192
Company strategy 193
Agilent Technologies, Inc. 193
Company overview 193
Products and services 193
Company strategy 194
Animech Technologies AB 195
Company overview 195
Products and services 195
Company strategy 195
Bruker Daltonics inc. 196
Company overview 196
Products and services 196
Company strategy 197
Ariadne Genomics 197
Company overview 197
Products and services 197
Company strategy 198
Biobase GmbH 198
Company overview 199
Products and services 199
Company strategy 199
BioDiscovery, Inc. 200
Company overview 200
Products and services 200
Company strategy 200
Bioinformatics Solutions Inc. 201
Company overview 201
Products and services 201
Company strategy 202
Biomatters Ltd 202
Company overview 202
Products and services 202
Company strategy 203
Biomax Informatics AG 203
Company overview 204
Products and services 204
Company strategy 205
BioWisdom Ltd 205
Company overview 206
Products and services 206
Company strategy 206
Celera Genomics Corporation 207
Company overview 207
Products and services 207
Company strategy 207
CLC bio 208
Company overview 208
Products and services 208
Company strategy 208
Geospiza, Inc. 209
Company overview 209
Products and services 209
Company strategy 210
Clontech Laboratories, Inc. 210
Company overview 210
Products and services 211
Company strategy 211
Definiens AG 211
Company overview 211
Products and services 212
Company strategy 212
DNASTAR, INC. 213
Company overview 213
Products and services 213
Company strategy 213
Expression Analysis, Inc. 214
Company overview 214
Products and services 214
Company strategy 214
Gene Logic 215
Company overview 215
Products and services 215
Company strategy 215
Genedata AG 216
Company overview 216
Products and services 216
Company strategy 217
GeneGo 217
Company overview 217
Products and services 217
Company strategy 218
Geneva Bioinformatics SA 218
Company overview 218
Products and services 219
Company strategy 219
Genologics Life Sciences Software 220
Company overview 220
Products and services 220
Company strategy 220
Genomatix Software Inc. 221
Company overview 221
Products and services 221
Company strategy 221
GenomeQuest, Inc. 222
Company overview 222
Products and services 222
Company strategy 222
Helicos Biosciences Corporation 224
Company overview 224
Products and services 224
Company strategy 224
Illumina Inc. 225
Company overview 225
Products and services 225
Company strategy 226
InforMax Inc. 226
Company overview 226
Products and services 227
Company strategy 227
Nucleics Pvt Ltd 227
Company overview 228
Products and services 228
Company strategy 228
Inforsense Limited 228
Company overview 229
Products and services 229
Company strategy 229
Kinexus Bioinformatics Corporation 229
Company overview 230
Products and services 230
Company strategy 230
MDS Inc. 231
Company overview 231
Products and services 231
Company strategy 231
Miraibio Group 232
Company overview 232
Products and services 232
Company strategy 232
Golden Helix, Inc 233
Company overview 233
Products and services 233
Company strategy 233
Invitrogen Corporation 234
Company overview 234
Products and services 234
Company strategy 234
Molegro 235
Company overview 235
Products and services 235
Company strategy 236
Nonlinear Dynamics 236
Company overview 236
Products and services 236
Company strategy 237
Textco Biosoftware, Inc. 237
Company overview 237
Products and services 238
Company strategy 238
Numerical Algorithms Group Ltd 238
Company overview 238
Products and services 239
Company strategy 239
Ocimum Biosolutions Ltd. 240
Company overview 240
Products and services 240
Company strategy 241
Partek Inc. 241
Company overview 241
Products and services 241
Company strategy 242
Phase Forward Inc. 242
Company overview 242
Products and services 242
Company strategy 243
Premier Biosoft International 243
Company overview 243
Products and services 244
Company strategy 244
Protein Forest Inc. 244
Company overview 245
Products and services 245
Company strategy 245
Rosetta Biosoftware 245
Company overview 245
Products and services 246
Company strategy 246
Silicon Graphics Inc. 247
Company overview 247
Products and services 247
Company strategy 247
Softberry Inc. 248
Company overview 248
Products and services 248
Company strategy 249
Softgenetics, LLC. 249
Company overview 249
Products and services 249
Company strategy 250
Strand Life Sciences 250
Company overview 250
Products and services 250
Company strategy 251
Synamatix Sdn Bhd 251
Company overview 251
Products and services 252
Company strategy 252
Teranode Corporation 252
Company overview 252
Products and services 253
Company strategy 253
Tibco Spotfire 253
Company overview 253
Products and services 253
Company strategy 254
Tripos International 254
Company overview 254
Products and services 254
Company strategy 255
Chapter 9 Appendix 256
Index 265
List of Figures
Figure 1.1: Bioinformatics components 29
Figure 1.2: Bioinformatics market segmentation 31
Figure 1.3: Market transition impacting bioinformatics market 32
Figure 1.4: Role of bioinformatics in drug development process 33
Figure 1.5: Comparative analysis of the bioinformatics application market 35
Figure 1.6: Relative importance of bioinformatic tool features (2009 vs 2014) 36
Figure 1.7: Market size versus growth in the bioinformatic tools market 37
Figure 1.8: Market size versus growth in the bioinformatic services market 39
Figure 1.9: Patents approved by technology (%), 2004 vs 2008 41
Figure 1.10: Patents approved by company, 2004-08 42
Figure 1.11: Regional approval of patents, 2004 vs 2008 43
Figure 2.12: Strategic focus of bioinformatics companies, 2008-09 48
Figure 3.13: Bioinformatic tools market dynamics 63
Figure 3.14: Level of market attractiveness of bioinformatic tools 65
Figure 3.15: Sequence analysis process and application of bioinformatic tools 68
Figure 4.16: Bioinformatics content/database market dynamics 110
Figure 5.17: Bioinformatics services market dynamics 129
Figure 5.18: Level of attractiveness of the bioinformatics services market 131
Figure 6.19: Regional distribution of bioinformatics applications market, 2009 and 2014 154
Figure 6.20: Global scenario for molecular medicine 159
Figure 6.21: Level of market attractiveness for other bioinformatic applications 168
Figure 7.22: Market revenues for Asia, 2008 vs 2014 177
Figure 7.23: Comparative impact of business environment (India and China), 2009 178
Figure 7.24: Indian bioinformatics market structure 179
Figure 7.25: Source of revenue for Indian bioinformatics firms 180
Figure 7.26: Major opportunities for Indian IT market players 181
Figure 7.27: Business opportunities in India and China 182
Figure 7.28: Key trends impacting India and China 184
List of Tables
Table 1.1: Global bioinformatics market by submarket, 2007–14($m) 44
Table 2.2: Recent mergers and acquisitions, 2008–09 49
Table 2.3: New product, technology or service launches, 2008–09 50
Table 2.4: New product, technology or service launches, 2008–09 (contd 1) 51
Table 2.5: New product, technology or service launches, 2008–09 (contd 2) 52
Table 2.6: New product, technology or service launches, 2008–09 (contd 3) 53
Table 3.7: Global bioinformatic tools market by product, 2007–14 ($m) 64
Table 3.8: Bioinformatic tools market by region, 2007–14 ($m) 64
Table 3.9: Global sequence analysis tools market by product function, 69
Table 3.10: Sequence analysis tools market by region, 2007–14 ($m) 70
Table 3.11: Global DNA sequence analysis tools market by product function, 2007–14 ($m) 71
Table 3.12: DNA sequence analysis tools market by region, 2007–14 ($m) 71
Table 3.13: Sequence alignment market by region, 2007–14 ($m) 72
Table 3.14: Gene detection market by region, 2007–14 ($m) 73
Table 3.15: Market for restriction and detection of repeats and unusual patterns by region, 2007– 14 ($m) 73
Table 3.16: Transcriptional elements detection market by region, 2007–14 ($m) 74
Table 3.17: tRNA detection market by region, 2007–14 ($m) 74
Table 3.18: Global protein function assignment market by product function, 2007–14 ($m) 75
Table 3.19: Protein function assignment market by region, 2007–14 ($m) 75
Table 3.20: Protein-protein interactions tools market by region, 2007–14 ($m) 76
Table 3.21: Market for pattern, motif, profiles, domains and families search by region, 2007–14 ($m) 76
Table 3.22: Search, computation and analysis of pathways market by region, 2007–14 ($m) 77
Table 3.23: Protein annotation market by region, 2007–14 ($m) 77
Table 3.24: Automatic alerts for related new sequences market by region, 2007–14 ($m) 78
Table 3.25: Global 3D structure analysis and modeling market by product function, 2007–14 ($m) 78
Table 3.26: 3D structure analysis and modeling market by region, 2007–14 ($m) 79
Table 3.27: 3D viewers market by region, 2007–14 ($m) 79
Table 3.28: 3D homology modeling market by region, 2007–14 ($m) 80
Table 3.29: 3D analysis market by region, 2007–14 ($m) 80
Table 3.30: RNA analysis tool market by region, 2007–14 ($m) 81
Table 3.31: Microarray data analysis market by region, 2007–14 ($m) 81
Table 3.32: Global phylogenetic analysis market by product function, 2007–14 ($m) 82
Table 3.33: Phylogenetic analysis market by region, 2007–14 ($m) 82
Table 3.34: Multiple sequence alignment market by region, 2007–14 ($m) 83
Table 3.35: Organism classification market by region, 2007–14 ($m) 83
Table 3.36: Sequence alignment tools market by product function, 2007–14 ($m) 84
Table 3.37: Sequence alignment tools market by region, 2007–14 ($m) 85
Table 3.38: Sequence analysis (alignment) tools market by product function, 2007–14 ($m) 86
Table 3.39: Sequence analysis (alignment) tools market by region, 2007–14 ($m) 87
Table 3.40: Multiple sequence alignment market by region, 2007–14 ($m) 87
Table 3.41: Phylogenetic tree building market by region, 2007–14 ($m) 88
Table 3.42: Consensus sequence and translation by region, 2007–14 ($m) 88
Table 3.43: Lab end-sequence analysis market by product function, 2007–14 ($m) 89
Table 3.44: Lab end-sequence analysis by region, 2007–14 ($m) 89
Table 3.45: Primer design market by region, 2007–14 ($m) 90
Table 3.46: Cloning market by region, 2007–14 ($m) 91
Table 3.47: Contig assembly market by region, 2007–14 ($m) 91
Table 3.48: Sequence manipulation tools market by product function, 2007–14 ($m) 92
Table 3.49: Sequence manipulation tools market by region, 2007–14 ($m) 92
Table 3.50: Sequence analysis (including sequence manipulation) market by region, 2007–14 ($m) 93
Table 3.51: Sequence manipulation market by region, 2007–14 ($m) 93
Table 3.52: Format conversion market by region, 2007–14 ($m) 94
Table 3.53: Random sequences market by region, 2007–14 ($m) 94
Table 3.54: Global structural analysis tools market by product function, 2007–14 ($m) 95
Table 3.55: Structural analysis tools market by region, 2007–14 ($m) 96
Table 3.56: Global sequence visualization market by product, 2007–14 ($m) 96
Table 3.57: Sequence visualization market by region, 2007–14 ($m) 97
Table 3.58: 3D protein structure market by region, 2007–14 ($m) 97
Table 3.59: Dot plots and others market by region, 2007–14 ($m) 98
Table 3.60: Graphical and phylogenetic tree viewer and editor market by region, 2007–14 ($m) 98
Table 3.61: Primary sequence analysis market by region, 2007–14 ($m) 99
Table 3.62: Physicochemical property alignment market by region, 2007–14 ($m) 100
Table 3.63: Alignment tools market by region, 2007–14 ($m) 100
Table 3.64: Tools to predict secondary structure sequence market by region, 2007–14 ($m) 101
Table 3.65: Global other tools market by product, 2007–14 ($m) 101
Table 3.66: Other tools market by region, 2007–14 ($m) 102
Table 3.67: Visualization tools market by product, 2007–14 ($m) 102
Table 3.68: Visualization tools market by region, 2007–14 ($m) 103
Table 3.69: Database viewers market by region, 2007–14 ($m) 103
Table 3.70: Sequence viewers market by region, 2007–14 ($m) 104
Table 3.71: Molecular viewers market by region, 2007–14 ($m) 104
Table 3.72: Physical mapping software market by region, 2007–14 ($m) 105
Table 4.73: Global content/database market by product, 2007–14 ($m) 110
Table 4.74: Content/database market by region, 2007–14 ($m) 111
Table 4.75: Global specialized database market by product, 2007–14 ($m) 113
Table 4.76: Specialized database market by region, 2007–14 ($m) 113
Table 4.77: Specialized sequence databases market by region, 2007–14 ($m) 114
Table 4.78: Global genome databases market by product, 2007–14 ($m) 115
Table 4.79: Genome databases market by region, 2007–14 ($m) 115
Table 4.80: Collections market by region, 2007–14 ($m) 116
Table 4.81: Model organism databases market by region, 2007–14 ($m) 116
Table 4.82: Global specialized protein databases market by product, 2007–14 ($m) 117
Table 4.83: Specialized protein databases market by region, 118
Table 4.84: Proteome databases market by region, 2007–14 ($m) 119
Table 4.85: Protein classification databases market by region, 2007–14 ($m) 119
Table 4.86: Specific protein family databases market by region, 2007–14 ($m) 120
Table 4.87: Specialized structural databases market by region, 2007–14 ($m) 120
Table 4.88: Microarray databases market by region, 2007–14 ($m) 121
Table 4.89: Pathway databases market by region, 2007–14 ($m) 121
Table 4.90: 2D-PAGE databases market by region, 2007–14 ($m) 122
Table 4.91: Global general database market by product, 2007–14 ($m) 123
Table 4.92: General database market by region, 2007–14 ($m) 123
Table 4.93: Primary sequence databases market by region, 2007–14 ($m) 124
Table 4.94: Protein sequence databases market by region, 2007–14 ($m) 124
Table 4.95: 3D structure databases market by region, 2007–14 ($m) 125
Table 4.96: Carbohydrate databases market by region, 2007–14 ($m) 125
Table 5.97: Global services market by product function, 2007–14 ($m) 130
Table 5.98: Services market by region, 2007–14 ($m) 130
Table 5.99: Global data analysis services market by product function, 2007–14 ($m) 133
Table 5.100: Data analysis services market by region, 2007–14 ($m) 133
Table 5.101: Genomics data analysis market services by region, 2007–14 ($m) 134
Table 5.102: Proteomics data analysis services market by region, 2007–14 ($m) 135
Table 5.103: Microarray data analysis services market by region, 2007–14 ($m) 135
Table 5.104: Modeling & computational bioinformatics services market by region, 2007–14 ($m) 136
Table 5.105: Global sequencing services market by product function, 2007–14 ($m) 137
Table 5.106: Sequencing services market by region, 2007–14 ($m) 137
Table 5.107: High-throughput sequencing market by region, 2007–14 ($m) 139
Table 5.108: Multiple sequence alignment market by region, 2007–14 ($m) 139
Table 5.109: Resequencing services market by region, 2007–14 ($m) 140
Table 5.110: Primer walking market by region, 2007–14 ($m) 140
Table 5.111: Expression profile clustering and sequence pattern market by region, 2007–14 ($m) 141
Table 5.112: Shotgun sequencing (bacterial artificial chromosomes and cosmids) market by region, 2007–14 ($m) 141
Table 5.113: Global database management market by product function, 2007–14 ($m) 142
Table 5.114: Database management market by region, 2007–14 ($m) 143
Table 5.115: Conception and realization market by region, 2007–14 ($m) 144
Table 5.116: User interface development market by region, 2007–14 ($m) 144
Table 5.117: Maintenance market by region, 2007–14 ($m) 145
Table 5.118: Backup system market by region, 2007–14 ($m) 145
Table 5.119: Migration market by region, 2007–14 ($m) 146
Table 5.120: Other services market by region, 2007–14 ($m) 146
Table 5.121: Other services market by region, 2007–14 ($m) 147
Table 5.122: Security system market by region, 2007–14 ($m) 147
Table 5.123: Data-mining services by region, 2007–14 ($m) 148
Table 5.124: Infrastructure integration services market by region, 2007–14 ($m) 149
Table 5.125: Knowledge management market by region, 2007–14 ($m) 150
Table 6.126: Global applications market by product segment, 2007–14 ($m) 153
Table 6.127: Global molecular medicine market by product segment, 2007–14 ($m) 158
Table 6.128: Global preventive medicine market by product segment, 2007–14 ($m) 161
Table 6.129: Global gene therapy market by product segment, 2007–14 ($m) 163
Table 6.130: Global drug development market by product function, 2007–14 ($m) 165
Table 6.131: Global other applications market by product function, 2007–14 ($m) 168
Table 7.132: Market forecast for bioinformatics by region, 2007–14 ($m) 173
Table 7.133: North American bioinformatics market, 2007–14 ($m) 174
Table 7.134: European bioinformatics market, 2007–14 ($m) 175
Table 7.135: Asian bioinformatics market, 2007–14 ($m) 176
Table 7.136: RoW bioinformatics market, 2007–14 ($m) 185
Table 9.137: US bioinformatics patents 256
Table 9.138: US bioinformatics patents (contd 1) 257
Table 9.139: US bioinformatics patents (contd 2) 258
Table 9.140: US bioinformatics patents (contd 3) 259
Table 9.141: European bioinformatics patents 260
Table 9.142: European bioinformatics patents (contd 1) 261
Table 9.143: European bioinformatics patents (contd 2) 262
Table 9.144: Japanese bioinformatics patents 262
Table 9.145: Japanese bioinformatics patents (contd 1) 263
Table 9.146: Japanese bioinformatics patents (contd 2) 264