US Prosthetic Heart Valves Market: Tissue Valves to Emerge as the Largest Segment

1 Table of contents 3
1.1 List of Tables 5
1.2 List of Figures 5
2 Introduction 6
2.1 Disease Overview: Valvular Heart Disease 6
2.1.1 Types of Valvular Heart Disease 6
2.2 Treatment Overview: Valvular Heart Disease 7
2.2.1 Valve Replacement 7
3 US Prosthetic Heart Valves: Market Characterization 8
3.1 US Prosthetic Heart Valves Market Revenue (2000–2015) 8
3.1.1 US Prosthetic Heart Valves, Historic Revenue (2000–2008): Market Remained Stable, Growing by Only 1% (CAGR) 8
3.1.2 US Prosthetic Heart Valves, Forecast Revenue: New Disruptive Technologies and Trend Towards Early Surgical Intervention to Drive Growth 9
3.2 US Prosthetic Heart Valves Market: Procedure Numbers (2000–2015) 10
3.2.1 US Prosthetic Heart Valves Market, Historic (2000–2008): Procedure Numbers Remained Stable 10
3.2.2 US Prosthetic Heart Valves Market, Forecast (2008–2015): Increasing Incidence of Valvular Heart Disease and Minimally Invasive Technolgies to Drive Procedure Numbers 11
3.3 US Prosthetic Heart Valves Market: Treatment Flow Analysis: Late Onset of Symptoms and Low Prescription Rate Reducing Actual Patients Treated 12
3.3.1 Patient Leakage at the Treatment Seeking Level 12
3.3.2 Low Prescription Rates Allowing Patient Leakage 13
4 US Prosthetic Heart Valves Market: Drivers and Restraints 14
4.1 US Prosthetic Heart Valves Market: Drivers 14
4.1.1 Aging Population Is Increasing the Number of People Requiring Valve Replacement Therapy and Will Drive Procedure Numbers 14
4.1.2 Technology Innovation for Enhanced Durability, Improved Hemodynamics and Reduced Surgery Time to Drive Adoption of Tissue Valves 14
4.1.3 Advances In Minimal Invasive Technology To Drive Valve Replacement In High Risk Patients 15
4.1.4 Lack of Viable Medical Alternatives for Severe Valvular Disease Will Continue To Sustain Procedure Numbers for Valve Replacements 15
4.2 US Prosthetic Heart Device Market Restraints 15
4.2.1 Market Maturity and Lack of New Groundbreaking Technology Ready for Immediate Commercialization will Limit Growth over the Next Two Years 15
4.2.2 Lack of Robust Clinical Data will Increase Diversity of Opinion Regarding Valvular Disease Management 16
4.2.3 Recent Advances in Catheter Technology Have Renewed Focus on Repair over Replacement 16
4.2.4 Steep Learning Curve and Uncertainty on The Long Term Effectiveness Of The Transcutaneous Procedures Will Deter Quick Adoption 16
5 US Prosthetic Heart Valves Market: Trends and Impact Analysis 17
5.1 Market Trends 17
5.1.1 Significant Shift in the Etiology of Valvular Heart Disease towards Degeneration and Calcification 17
5.1.2 Rising Age and Comorbidities in Valvular Heart Disease Patients Are Moving the Focus to Transcatheter Valves 17
5.2 Impact Analysis 18
6 US Prosthetic Heart Valves Market: Segment Analysis 20
7 US Tissue Heart Valves Market: Revenues (2000–2015) 21
7.1 US Tissue Heart Valves Market, Historic : Driven by Improved Durability of Products 21
7.1.1 US Tissue Heart Device Market, Forecast: Design Innovation and Improved Durability to Drive the Market 22
7.2 US Tissue Heart Valves Market: Procedure Numbers (2000–2015) 23
7.2.1 US Tissue Heart Valves Market, Historic, (2000–2008): Driven by Improved Durability and Low Morbidity Associated With Anticoagulation Therapy 23
7.2.2 US Tissue Heart Valves Market: Forecast Procedure Numbers (2008–2015): Improved Durability Will Continue to Drive the Tissue Heart Valve Replacement Procedures 24
7.3 Market Drivers for the US Tissue Heart Valves Market 24
7.4 Market Restraints For US Tissue Heart Valves Market 25
7.5 US Mechanical Heart Valves Market: Revenues (2000–2015) 25
7.5.1 US Mechanical Heart Valves Market: Historic Revenues (2000–2008): Market Decline Due To Lifelong Anticoagulation Therapy 25
7.5.2 US Mechanical Heart Valves Market: Forecast Revenues (2008–2015): Further Market Decline Due To the Rising Age Of Patients Suffering From Valvular Heart Disease 26
7.6 US Mechanical Heart Valves Market: Procedure Numbers (2000–2015) 27
7.6.1 US Mechanical Heart Valves Market: Historic Procedure Numbers (2000–2008): High Risk of Hemorrhagic Complications Due To Lifelong Anticoagulation Therapy Led To Declining Procedure Numbers 27
7.6.2 US Mechanical Heart Valves Market: Forecast Procedure Numbers (2008–2015): High Risk of Hemorrhagic Complications Due To Lifelong Anticoagulation Therapy Will Continue To Lead To Declining Procedure Numbers 28
7.7 Market Drivers for US Mechanical Heart Valves Market 28
7.8 Market Restraints for US Mechanical Heart Valves Market 28
8 US Prosthetic Heart Valves Market: Competitive Landscape 29
8.1 Company Profiles 29
8.1.1 Edwards Lifesciences Corporation 29
8.1.2 Medtronic, Inc 30
8.1.3 St. Jude Medical, Inc. 31
9 US Prosthetic Heart Valves Market: Deals Analysis 32
9.1 Intense Merger And Acquisition Activity Was Witnessed In 2008–2009 To Build Pipeline Portfolios For Transcatheter Valves 32
9.2 Mergers and Acquisitions 33
9.2.1 Abbott Laboratories To Acquire Evalve 33
9.2.2 Medtronic Acquires CoreValve From Sofinnova Partners, Apax Partners, HealthCap And Maverick Capital 33
9.2.3 Medtronic Acquires Ventor Technologies 33
9.2.4 Getinge Acquires Datascope 33
9.3 Partnership Agreements 2008–2009 34
9.3.1 AorTech International Enters Into Licensing Agreement With SynCardia Systems 34
9.3.2 Medtronic Enters Into Licensing Agreement With Arbor Surgical Technologies 34
10 US Prosthetic Heart Valves Market: Pipeline Analysis 35
10.1 Transcatheter Valves And Novel Designs In Tissue Heart Valves From The Major Pipeline Products Of Top Companies 35
10.2 Key Pipeline Products 36
10.2.1 Edwards SAPIEN Transcatheter Heart Valve 36
10.2.2 CoreValve ReValving System 36
10.2.3 Ventor Embracer 36
10.2.4 Melody Transcatheter Pulmonary Valve 36
10.2.5 ATS 3f Enable Aortic Heart Valve 36
11 Appendix 37
11.1 Definitions 37
11.1.1 Cardiovascular Prosthetic Devices 37
11.1.2 Prosthetic Heart Valve 37
11.2 Acronyms 37
11.3 Research Methodology 38
11.4 Secondary Research 38
11.5 Primary Research 39
11.6 Models 39
11.7 Forecasts 39
11.8 Expert Panels 40
11.9 GlobalData Consulting 40
11.10 Contact Us 40
11.11 Disclaimer 40

1.1 List of Tables
Table 1: Prosthetic Heart Valves, US, Revenue ($m), 2000–2008 8
Table 2: Prosthetic Heart Valves, US, Revenue ($m), 2008–2015 9
Table 3: Prosthetic Heart Valves, US, Procedure Numbers, 2000–2008 10
Table 4: Prosthetic Heart Valves, US, Procedure Numbers, 2008–2015 11
Table 5: US Prosthetic Heart Valves Market, Impact analysis 18
Table 6: Prosthetic Heart Valves, Segment Revenue Contribution (Percentage), US, 2000–2015 20
Table 7: Tissue Heart Valves, US, Revenue ($m), 2000–2008 21
Table 8: Tissue Heart Valves, US, Revenue ($m), 2008–2015 22
Table 9: Tissue Heart Valves, US, Procedure Numbers, 2000–2008 23
Table 10: Tissue Heart Valves, US, Procedure Numbers, 2008–2015 24
Table 11: Mechanical Heart Valves, US, Revenue ($m), 2000–2008 25
Table 12: Mechanical Heart Valves, US, Revenue ($m), 2008–2015 26
Table 13: Mechanical Heart Valves, US, Procedure Numbers, 2000–2008 27
Table 14: Mechanical Heart Valves, US, Procedure Numbers, 2000–2015 28
Table 15: Pipeline Prosthetic Heart Valves, US 35

1.2 List of Figures
Figure 1: Prosthetic Heart Valves, US, Revenue ($m), 2000–2008 8
Figure 2: Prosthetic Heart Valves, US, Revenue ($m), 2008–2015 9
Figure 3: Prosthetic Heart Valves, US, Procedure Numbers, 2000–2008 10
Figure 4: Prosthetic Heart Valves, US, Procedure Numbers, 2008–2015 11
Figure 5: Treatment Flow Analysis: Valvular Heart Disease in the US, 2008 12
Figure 6: Growth Rates for Treatment Flow Patterns, 2008–2015 13
Figure 7: US Prosthetic Heart Valves Market: Drivers and Restraints 14
Figure 8: US Prosthetic Heart Valves Market: Trends 17
Figure 9: Expected Market Events, Prosthetic Heart Valves Market, Impact Analysis, US, 2010–2015 18
Figure 10: Prosthetic Heart Valves, Segment Revenue Contribution (Percentage), US, 2000–2015 20
Figure 11: Tissue Heart Valves, US, Revenue ($m), 2000–2008 21
Figure 12: Tissue Heart Valves, US, Revenue ($m), 2008–2015 22
Figure 13: Tissue Heart Valves, US, Procedure Numbers, 2000–2008 23
Figure 14: Tissue Heart Valves, US, Procedure Numbers, 2008–2015 24
Figure 15: Mechanical Heart Valves, US, Revenue ($m), 2000–2008 25
Figure 16: Mechanical Heart Valves, US, Revenue ($m), 2008–2015 26
Figure 17: Mechanical Heart Valves, US, Procedure Numbers, 2000–2008 27
Figure 18: Mechanical Heart Valves, US, Procedure Numbers, 2000–2015 28
Figure 19: Prosthetic Heart Valves Market, Company Share, US, 2008 29
Figure 20: Prosthetic Heart Valves, Deal Value ($m) and Volume, US, 2008–2009 32
Figure 21: Prosthetic Heart Valves, Deal Type, US, 2008–2009 32
Figure 22: GlobalData Methodology 38